BDBM545471 US11286268, Compound 962

SMILES: Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(Cl)c(Nc4cncc(F)c4)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1

InChI Key: InChIKey=WANYWEPVLVGYAU-UHFFFAOYSA-N

Data: 1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545471   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Eukaryotic translation initiation factor 4E-binding protein 1 (Homo sapiens (Human))	BDBM545471 (US11286268, Compound 962) Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(Cl)c(Nc4cncc(F)c4)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1 Show InChI InChI=1S/C32H21Cl2FN6O4S/c1-15-7-21(30-29(38-15)23(14-46-30)32(43)44)20-8-17(33)3-4-26(20)45-6-5-41-16(2)39-25-10-24(34)28(22(11-36)27(25)31(41)42)40-19-9-18(35)12-37-13-19/h3-4,7-10,12-14,40H,5-6H2,1-2H3,(H,43,44)	PDB KEGG UniProtKB/SwissProt GoogleScholar	UniChem	US Patent	n/a	n/a	3.15	n/a	n/a	n/a	n/a	n/a	n/a
eFFECTOR Therapeutics, Inc. US Patent					Assay Description eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...				US Patent US11286268 (2022)
					More data for this Ligand-Target Pair