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BDBM545471 US11286268, Compound 962

SMILES: Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(Cl)c(Nc4cncc(F)c4)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1

InChI Key: InChIKey=WANYWEPVLVGYAU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545471   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545471
PNG
(US11286268, Compound 962)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(Cl)c(Nc4cncc(F)c4)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C32H21Cl2FN6O4S/c1-15-7-21(30-29(38-15)23(14-46-30)32(43)44)20-8-17(33)3-4-26(20)45-6-5-41-16(2)39-25-10-24(34)28(22(11-36)27(25)31(41)42)40-19-9-18(35)12-37-13-19/h3-4,7-10,12-14,40H,5-6H2,1-2H3,(H,43,44)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 3.15n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair