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Found 178 with Last Name = 'groutas' and Initial = 'wc'
TargetNeutrophil elastase(Homo sapiens (Human))
Wichita State University

Curated by ChEMBL
LigandPNGBDBM50376931(CHEMBL260190)
Affinity DataKi:  5.5nMAssay Description:Inhibition human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Wichita State University

Curated by ChEMBL
LigandPNGBDBM50326180((RS)-Benzyl1-((RS)-3-benzyl-4-isobutyl-5-oxoimidaz...)
Affinity DataKi:  7.34E+3nMAssay Description:Reversible competitive inhibition of human neutrophil elastase by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Wichita State University

Curated by ChEMBL
LigandPNGBDBM50280338(2-((S)-3-Amino-5-methyl-2-oxo-hexyl)-isoindole-1,3...)
Affinity DataKi:  1.75E+4nMAssay Description:Compound was tested for the inhibition of human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Wichita State University

Curated by ChEMBL
LigandPNGBDBM50025846(2-[(Imidazole-1-carbonyl)-amino]-pentanoic acid me...)
Affinity DataKi:  3.20E+5nMAssay Description:Ki value was evaluated for the inhibition of human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-like elastase family member 1/2A(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50225469(CHEMBL302653)
Affinity DataKi:  4.70E+5nMAssay Description:Ki value was evaluated for the inhibition of porcine pancreatic elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-like elastase family member 1/2A(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50025846(2-[(Imidazole-1-carbonyl)-amino]-pentanoic acid me...)
Affinity DataKi:  8.40E+5nMAssay Description:Ki value was evaluated for the inhibition of porcine pancreatic elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Wichita State University

Curated by ChEMBL
LigandPNGBDBM50025852(2-[(Imidazole-1-carbonyl)-amino]-hexanoic acid met...)
Affinity DataKi:  1.00E+6nMAssay Description:Ki value was evaluated for the inhibition of human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-like elastase family member 1/2A(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50025849(2-[(Imidazole-1-carbonyl)-amino]-3-methyl-butyric ...)
Affinity DataKi:  1.11E+6nMAssay Description:Ki value was evaluated for the inhibition of porcine pancreatic elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-like elastase family member 1/2A(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50225473(CHEMBL65258)
Affinity DataKi:  1.17E+6nMAssay Description:Ki value was evaluated for the inhibition of porcine pancreatic elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-like elastase family member 1/2A(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50225471(CHEMBL63295)
Affinity DataKi:  1.22E+6nMAssay Description:Ki value was evaluated for the inhibition of porcine pancreatic elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-like elastase family member 1/2A(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50225472(CHEMBL63484 | Imidazole-1-Carboxylic Acid Butylami...)
Affinity DataKi:  1.40E+6nMAssay Description:Ki value was evaluated for the inhibition of porcine pancreatic elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Wichita State University

Curated by ChEMBL
LigandPNGBDBM50025849(2-[(Imidazole-1-carbonyl)-amino]-3-methyl-butyric ...)
Affinity DataKi:  1.80E+6nMAssay Description:Ki value was evaluated for the inhibition of human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-like elastase family member 1/2A(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50025852(2-[(Imidazole-1-carbonyl)-amino]-hexanoic acid met...)
Affinity DataKi:  1.94E+6nMAssay Description:Ki value was evaluated for the inhibition of porcine pancreatic elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-like elastase family member 1/2A(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50225467(CHEMBL293476)
Affinity DataKi:  2.41E+6nMAssay Description:Ki value was evaluated for the inhibition of porcine pancreatic elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-like elastase family member 1/2A(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50225470(CHEMBL294543)
Affinity DataKi:  2.41E+6nMAssay Description:Ki value was evaluated for the inhibition of porcine pancreatic elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-like elastase family member 1/2A(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50225468(CHEMBL63581)
Affinity DataKi:  7.23E+6nMAssay Description:Ki value was evaluated for the inhibition of porcine pancreatic elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
Wichita State University

LigandPNGBDBM476929(SARS-CoV-2 3CLpro Inhibitors 3a | SARS-CoV-2 3CLpr...)
Affinity DataIC50:  49nMAssay Description:Cloning and Expression of the 3CL Protease of SARS-CoV-2 and FRET Enzyme Assays. The codon-optimized cDNA of full length of 3CLpro of SARS-CoV-2 (Gen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
Wichita State University

LigandPNGBDBM476928(SARS-CoV-2 3CLpro Inhibitors 2a | SARS-CoV-2 3CLpr...)
Affinity DataIC50:  52nMAssay Description:Cloning and Expression of the 3CL Protease of SARS-CoV-2 and FRET Enzyme Assays. The codon-optimized cDNA of full length of 3CLpro of SARS-CoV-2 (Gen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
Wichita State University

LigandPNGBDBM476949(SARS-CoV-2 3CLpro Inhibitors 3k | SARS-CoV-2 3CLpr...)
Affinity DataIC50:  53nMAssay Description:Cloning and Expression of the 3CL Protease of SARS-CoV-2 and FRET Enzyme Assays. The codon-optimized cDNA of full length of 3CLpro of SARS-CoV-2 (Gen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
Wichita State University

LigandPNGBDBM476948(SARS-CoV-2 3CLpro Inhibitors 2k | SARS-CoV-2 3CLpr...)
Affinity DataIC50:  55nMAssay Description:Cloning and Expression of the 3CL Protease of SARS-CoV-2 and FRET Enzyme Assays. The codon-optimized cDNA of full length of 3CLpro of SARS-CoV-2 (Gen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
Wichita State University

LigandPNGBDBM476939(SARS-CoV-2 3CLpro Inhibitors 3f)
Affinity DataIC50:  58nMAssay Description:Cloning and Expression of the 3CL Protease of SARS-CoV-2 and FRET Enzyme Assays. The codon-optimized cDNA of full length of 3CLpro of SARS-CoV-2 (Gen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
Wichita State University

LigandPNGBDBM476938(SARS-CoV-2 3CLpro Inhibitors 2f)
Affinity DataIC50:  63nMAssay Description:Cloning and Expression of the 3CL Protease of SARS-CoV-2 and FRET Enzyme Assays. The codon-optimized cDNA of full length of 3CLpro of SARS-CoV-2 (Gen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOrf1a protein(MERS-CoV)
Wichita State University

LigandPNGBDBM419129(3CLpro inhibitor 6h)
Affinity DataIC50:  70nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOrf1a protein(MERS-CoV)
Wichita State University

LigandPNGBDBM419131(3CLpro inhibitor 6j | 3CLpro inhibitor 7j)
Affinity DataIC50:  80nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOrf1a protein(MERS-CoV)
Wichita State University

LigandPNGBDBM419130(3CLpro inhibitor 7h)
Affinity DataIC50:  80nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOrf1a protein(MERS-CoV)
Wichita State University

LigandPNGBDBM419131(3CLpro inhibitor 6j | 3CLpro inhibitor 7j)
Affinity DataIC50:  100nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Wichita State University

LigandPNGBDBM476939(SARS-CoV-2 3CLpro Inhibitors 3f)
Affinity DataIC50:  100nMAssay Description:Cloning and Expression of the 3CL Protease of SARS-CoV-2 and FRET Enzyme Assays. The codon-optimized cDNA of full length of 3CLpro of SARS-CoV-2 (Gen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOrf1a protein(MERS-CoV)
Wichita State University

LigandPNGBDBM419126(3CLpro inhibitor 7c)
Affinity DataIC50:  100nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOrf1a protein(MERS-CoV)
Wichita State University

LigandPNGBDBM419128(3CLpro inhibitor 7e)
Affinity DataIC50:  130nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Wichita State University

LigandPNGBDBM476938(SARS-CoV-2 3CLpro Inhibitors 2f)
Affinity DataIC50:  140nMAssay Description:Cloning and Expression of the 3CL Protease of SARS-CoV-2 and FRET Enzyme Assays. The codon-optimized cDNA of full length of 3CLpro of SARS-CoV-2 (Gen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOrf1a protein(MERS-CoV)
Wichita State University

LigandPNGBDBM419124(3CLpro inhibitor 6c)
Affinity DataIC50:  150nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Wichita State University

LigandPNGBDBM476949(SARS-CoV-2 3CLpro Inhibitors 3k | SARS-CoV-2 3CLpr...)
Affinity DataIC50:  150nMAssay Description:Cloning and Expression of the 3CL Protease of SARS-CoV-2 and FRET Enzyme Assays. The codon-optimized cDNA of full length of 3CLpro of SARS-CoV-2 (Gen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOrf1a protein(MERS-CoV)
Wichita State University

LigandPNGBDBM419127(3CLpro inhibitor 6e)
Affinity DataIC50:  150nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOrf1a protein(MERS-CoV)
Wichita State University

LigandPNGBDBM419123(3CLpro inhibitor 7a)
Affinity DataIC50:  150nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Wichita State University

LigandPNGBDBM476929(SARS-CoV-2 3CLpro Inhibitors 3a | SARS-CoV-2 3CLpr...)
Affinity DataIC50:  170nMAssay Description:Cloning and Expression of the 3CL Protease of SARS-CoV-2 and FRET Enzyme Assays. The codon-optimized cDNA of full length of 3CLpro of SARS-CoV-2 (Gen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Wichita State University

LigandPNGBDBM419127(3CLpro inhibitor 6e)
Affinity DataIC50:  170nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Wichita State University

LigandPNGBDBM476928(SARS-CoV-2 3CLpro Inhibitors 2a | SARS-CoV-2 3CLpr...)
Affinity DataIC50:  180nMAssay Description:Cloning and Expression of the 3CL Protease of SARS-CoV-2 and FRET Enzyme Assays. The codon-optimized cDNA of full length of 3CLpro of SARS-CoV-2 (Gen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Wichita State University

LigandPNGBDBM476948(SARS-CoV-2 3CLpro Inhibitors 2k | SARS-CoV-2 3CLpr...)
Affinity DataIC50:  180nMAssay Description:Cloning and Expression of the 3CL Protease of SARS-CoV-2 and FRET Enzyme Assays. The codon-optimized cDNA of full length of 3CLpro of SARS-CoV-2 (Gen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Wichita State University

LigandPNGBDBM419128(3CLpro inhibitor 7e)
Affinity DataIC50:  200nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Kansas State University

Curated by ChEMBL
LigandPNGBDBM50273967(CHEMBL2441741)
Affinity DataIC50:  230nMAssay Description:Inhibition of SARS coronavirus 3C-like protease by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Wichita State University

LigandPNGBDBM419126(3CLpro inhibitor 7c)
Affinity DataIC50:  230nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Wichita State University

LigandPNGBDBM50606201(CHEMBL5205014)
Affinity DataIC50:  240nMAssay Description:Inhibition of N-terminal His6-tagged SARS-CoV2 Wuhan-Hu-1 3C-like protease infected in expressed in Escherichia coli BL21 (DE3) cells using FAM-SAVLQ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Wichita State University

LigandPNGBDBM50606200(CHEMBL5171724)
Affinity DataIC50:  240nMAssay Description:Inhibition of N-terminal His6-tagged SARS-CoV2 Wuhan-Hu-1 3C-like protease infected in expressed in Escherichia coli BL21 (DE3) cells using FAM-SAVLQ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Wichita State University

LigandPNGBDBM476953(SARS-CoV-2 3CLpro Inhibitors 3m)
Affinity DataIC50:  250nMAssay Description:Cloning and Expression of the 3CL Protease of SARS-CoV-2 and FRET Enzyme Assays. The codon-optimized cDNA of full length of 3CLpro of SARS-CoV-2 (Gen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Wichita State University

LigandPNGBDBM476936(SARS-CoV-2 3CLpro Inhibitors 2e)
Affinity DataIC50:  260nMAssay Description:Cloning and Expression of the 3CL Protease of SARS-CoV-2 and FRET Enzyme Assays. The codon-optimized cDNA of full length of 3CLpro of SARS-CoV-2 (Gen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Wichita State University

LigandPNGBDBM476933(SARS-CoV-2 3CLpro Inhibitors 3c | SARS-CoV-2 3CLpr...)
Affinity DataIC50:  260nMAssay Description:Cloning and Expression of the 3CL Protease of SARS-CoV-2 and FRET Enzyme Assays. The codon-optimized cDNA of full length of 3CLpro of SARS-CoV-2 (Gen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Wichita State University

LigandPNGBDBM50606187(CHEMBL5209543)
Affinity DataIC50:  260nMAssay Description:Inhibition of N-terminal His6-tagged SARS-CoV2 Wuhan-Hu-1 3C-like protease infected in expressed in Escherichia coli BL21 (DE3) cells using FAM-SAVLQ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Wichita State University

LigandPNGBDBM50606186(CHEMBL5172622)
Affinity DataIC50:  260nMAssay Description:Inhibition of N-terminal His6-tagged SARS-CoV2 Wuhan-Hu-1 3C-like protease infected in expressed in Escherichia coli BL21 (DE3) cells using FAM-SAVLQ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Wichita State University

LigandPNGBDBM476952(SARS-CoV-2 3CLpro Inhibitors 2m)
Affinity DataIC50:  270nMAssay Description:Cloning and Expression of the 3CL Protease of SARS-CoV-2 and FRET Enzyme Assays. The codon-optimized cDNA of full length of 3CLpro of SARS-CoV-2 (Gen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Wichita State University

LigandPNGBDBM476949(SARS-CoV-2 3CLpro Inhibitors 3k | SARS-CoV-2 3CLpr...)
Affinity DataIC50:  270nMAssay Description:Cloning and Expression of the 3CL Protease of SARS-CoV-2 and FRET Enzyme Assays. The codon-optimized cDNA of full length of 3CLpro of SARS-CoV-2 (Gen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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