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Found 105 with Last Name = 'takemoto' and Initial = 't'
TargetSphingomyelinase C(Bacillus cereus)
Tokushima Bunri University

LigandPNGBDBM248063(SMY-540)
Affinity DataKi:  1.30E+3nM ΔG°:  -34.9kJ/mole IC50:  800nMpH: 7.5 T: 2°CAssay Description:Briefly, Bc-SMase (50 ng/ml) was treated at 37 °C for 60 min with various compounds that were solubilized in dimethylacetoamide. The reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingomyelinase C(Bacillus cereus)
Tokushima Bunri University

LigandPNGBDBM248061(SMY-471)
Affinity DataKi:  2.80E+3nM ΔG°:  -33.0kJ/mole IC50:  900nMpH: 7.5 T: 2°CAssay Description:Briefly, Bc-SMase (50 ng/ml) was treated at 37 °C for 60 min with various compounds that were solubilized in dimethylacetoamide. The reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingomyelinase C(Bacillus cereus)
Tokushima Bunri University

LigandPNGBDBM248057(RY221B-a)
Affinity DataKi:  5.20E+3nM ΔG°:  -31.4kJ/mole IC50:  1.20E+3nMpH: 7.5 T: 2°CAssay Description:Briefly, Bc-SMase (50 ng/ml) was treated at 37 °C for 60 min with various compounds that were solubilized in dimethylacetoamide. The reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50403793(CHEMBL2115415)
Affinity DataIC50:  0.720nMAssay Description:The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 3 of male guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50310094((7-carbamoyl-8H-indeno[1,2-d]thiazol-4-yloxy)methy...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human liver recombinant FBPaseMore data for this Ligand-Target Pair
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50310095((7-(methylcarbamoyl)-8H-indeno[1,2-d]thiazol-4-ylo...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human liver recombinant FBPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50090485(CHEMBL295615 | spiro[(2-hydroxy)indane-1,40-piperi...)
Affinity DataIC50:  2.70nMAssay Description:The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 3 of male guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50310093((7-(pyrimidin-5-yl)-8H-indeno[1,2-d]thiazol-4-ylox...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human liver recombinant FBPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50403793(CHEMBL2115415)
Affinity DataIC50:  3.10nMAssay Description:The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 2 of male guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50090485(CHEMBL295615 | spiro[(2-hydroxy)indane-1,40-piperi...)
Affinity DataIC50:  6.80nMAssay Description:The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 2 of male guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50310086((7-chloro-8H-indeno[1,2-d]thiazol-4-yloxy)methylph...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human liver recombinant FBPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50310083((7-methyl-8H-indeno[1,2-d]thiazol-4-yloxy)methylph...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human liver recombinant FBPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50310088((6,7-difluoro-8H-indeno[1,2-d]thiazol-4-yloxy)meth...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human liver recombinant FBPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50310092((7-(pyridin-4-yl)-8H-indeno[1,2-d]thiazol-4-yloxy)...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human liver recombinant FBPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50310091((7-(pyridin-3-yl)-8H-indeno[1,2-d]thiazol-4-yloxy)...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human liver recombinant FBPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50293594(5-(2-amino-5-isobutylthiazol-4-yl)furan-2-ylphosph...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human liver FBPaseMore data for this Ligand-Target Pair
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50293594(5-(2-amino-5-isobutylthiazol-4-yl)furan-2-ylphosph...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human liver recombinant FBPaseMore data for this Ligand-Target Pair
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50310087((6,7-dimethyl-8H-indeno[1,2-d]thiazol-4-yloxy)meth...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human liver recombinant FBPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50403790(CHEMBL2114963)
Affinity DataIC50:  11nMAssay Description:The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 3 of male guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50310084((7-ethyl-8H-indeno[1,2-d]thiazol-4-yloxy)methylpho...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human liver recombinant FBPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50310082((8H-indeno[1,2-d]thiazol-4-yloxy)methylphosphonic ...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human liver recombinant FBPaseMore data for this Ligand-Target Pair
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50302495(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-8-yl...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human liver FBPaseMore data for this Ligand-Target Pair
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50310085((7-fluoro-8H-indeno[1,2-d]thiazol-4-yloxy)methylph...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human liver recombinant FBPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50090487(CHEMBL298247 | spiro[(2-hydroxy)indane-1,40-piperi...)
Affinity DataIC50:  17nMAssay Description:The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 3 of male guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50403793(CHEMBL2115415)
Affinity DataIC50:  21nMAssay Description:The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 1 of male guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50302497(CHEMBL572208 | Phosphoric acid mono-2-amino-5,6-di...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human liver FBPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50310089((7-phenyl-8H-indeno[1,2-d]thiazol-4-yloxy)methylph...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human liver recombinant FBPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50310090((7-(pyridin-2-yl)-8H-indeno[1,2-d]thiazol-4-yloxy)...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human liver recombinant FBPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50090485(CHEMBL295615 | spiro[(2-hydroxy)indane-1,40-piperi...)
Affinity DataIC50:  40nMAssay Description:The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 1 of male guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50090487(CHEMBL298247 | spiro[(2-hydroxy)indane-1,40-piperi...)
Affinity DataIC50:  45nMAssay Description:The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 2 of male guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50302506((2-amino-4,5-dihydronaphtho[1,2-d]thiazol-8-yl)dif...)
Affinity DataIC50:  47nMAssay Description:Inhibition of human liver FBPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50403790(CHEMBL2114963)
Affinity DataIC50:  59nMAssay Description:The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 2 of male guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50302493(2-amino-8H-indeno[1,2-d]thiazol-4-yl dihydrogen ph...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human liver FBPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50302500((2-amino-8H-indeno[1,2-d]thiazol-4-yloxy)methylpho...)
Affinity DataIC50:  124nMAssay Description:Inhibition of human liver recombinant FBPaseMore data for this Ligand-Target Pair
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50302500((2-amino-8H-indeno[1,2-d]thiazol-4-yloxy)methylpho...)
Affinity DataIC50:  124nMAssay Description:Inhibition of human liver FBPaseMore data for this Ligand-Target Pair
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50302490((2-Amino-5,6-dihydro-4H-3-thia-1-aza-benzo[e]azule...)
Affinity DataIC50:  169nMAssay Description:Inhibition of human liver FBPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50403790(CHEMBL2114963)
Affinity DataIC50:  220nMAssay Description:The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 1 of male guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50090487(CHEMBL298247 | spiro[(2-hydroxy)indane-1,40-piperi...)
Affinity DataIC50:  270nMAssay Description:The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 1 of male guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50403791(CHEMBL2114965)
Affinity DataIC50:  520nMAssay Description:The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 3 of male guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50403792(CHEMBL2115416)
Affinity DataIC50:  660nMAssay Description:The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 3 of male guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50310081((2-bromo-8H-indeno[1,2-d]thiazol-4-yloxy)methylpho...)
Affinity DataIC50:  772nMAssay Description:Inhibition of human liver recombinant FBPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50302505((2-amino-4,5-dihydronaphtho[1,2-d]thiazol-8-yl)met...)
Affinity DataIC50:  840nMAssay Description:Inhibition of human liver FBPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50310080((2-chloro-8H-indeno[1,2-d]thiazol-4-yloxy)methylph...)
Affinity DataIC50:  908nMAssay Description:Inhibition of human liver recombinant FBPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50310079((2-methyl-8H-indeno[1,2-d]thiazol-4-yloxy)methylph...)
Affinity DataIC50:  995nMAssay Description:Inhibition of human liver recombinant FBPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50090484(CHEMBL46795 | spiro[(2-hydroxy)indane-1,40-piperid...)
Affinity DataIC50: >1.00E+3nMAssay Description:The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 1 of male guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50090484(CHEMBL46795 | spiro[(2-hydroxy)indane-1,40-piperid...)
Affinity DataIC50: >1.00E+3nMAssay Description:The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 3 of male guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50090484(CHEMBL46795 | spiro[(2-hydroxy)indane-1,40-piperid...)
Affinity DataIC50: >1.00E+3nMAssay Description:The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 2 of male guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50090482(CHEMBL295785 | spiro[(2-hydroxy)indane-1,40-piperi...)
Affinity DataIC50: >1.00E+3nMAssay Description:The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 1 of male guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50403791(CHEMBL2114965)
Affinity DataIC50: >1.00E+3nMAssay Description:The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 2 of male guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50090482(CHEMBL295785 | spiro[(2-hydroxy)indane-1,40-piperi...)
Affinity DataIC50: >1.00E+3nMAssay Description:The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 2 of male guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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