TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Pennsylvania
Curated by ChEMBL
University Of Pennsylvania
Curated by ChEMBL
Affinity DataKi: 0.00900nMAssay Description:Binding affinity for serotonin transporter expresed in LCK PK1 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Pennsylvania
Curated by ChEMBL
University Of Pennsylvania
Curated by ChEMBL
Affinity DataKi: 0.0100nMAssay Description:Binding affinity for serotonin transporter expresed in LCK PK1 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Pennsylvania
Curated by ChEMBL
University Of Pennsylvania
Curated by ChEMBL
Affinity DataKi: 0.0900nMAssay Description:Binding affinity for serotonin transporter expresed in LCK PK1 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Pennsylvania
Curated by ChEMBL
University Of Pennsylvania
Curated by ChEMBL
Affinity DataKi: 0.120nMAssay Description:Binding affinity for serotonin transporter expresed in LCK PK1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.140nMAssay Description:Displacement of [3H]-PDBU from protein kinase C-alphaMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Pennsylvania
Curated by ChEMBL
University Of Pennsylvania
Curated by ChEMBL
Affinity DataKi: 0.370nMAssay Description:Binding affinity for serotonin transporter expresed in LCK PK1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.540nMAssay Description:Displacement of [3H]-PDBU from protein kinase C-alphaMore data for this Ligand-Target Pair
Affinity DataKi: 1nM ΔG°: -50.9kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
Affinity DataKi: 1nM ΔG°: -50.9kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Pennsylvania
Curated by ChEMBL
University Of Pennsylvania
Curated by ChEMBL
Affinity DataKi: 1.10nMAssay Description:Binding affinity for serotonin transporter expresed in LCK PK1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nM IC50: 2.5nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
University Of Pennsylvania
Curated by ChEMBL
University Of Pennsylvania
Curated by ChEMBL
Affinity DataKi: 1.60nMAssay Description:Binding affinity for Norepinephrine transporter (NET) expressed in LCK PK1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 3nM ΔG°: -48.2kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
Affinity DataKi: 3nM ΔG°: -48.2kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
Affinity DataKi: 4nM ΔG°: -47.5kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
Affinity DataKi: 6nM ΔG°: -46.5kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
Affinity DataKi: 6nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
Affinity DataKi: 6nM ΔG°: -46.5kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Pennsylvania
US Patent
University Of Pennsylvania
US Patent
Affinity DataKi: 6.90nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
Affinity DataKi: 8nM ΔG°: -45.7kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
University Of Pennsylvania
Curated by ChEMBL
University Of Pennsylvania
Curated by ChEMBL
Affinity DataKi: 11.3nMAssay Description:Binding affinity for Norepinephrine transporter (NET) expressed in LCK PK1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 13nM ΔG°: -44.6kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
Affinity DataKi: 15nM IC50: 44nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
Affinity DataKi: 15nM ΔG°: -44.2kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
Affinity DataKi: 16nM ΔG°: -44.0kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
University Of Pennsylvania
Curated by ChEMBL
University Of Pennsylvania
Curated by ChEMBL
Affinity DataKi: 17nMAssay Description:Binding affinity for Norepinephrine transporter (NET) expressed in LCK PK1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 18nM ΔG°: -43.8kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
Affinity DataKi: 19nM IC50: 31nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
University Of Pennsylvania
Curated by ChEMBL
University Of Pennsylvania
Curated by ChEMBL
Affinity DataKi: 20nMAssay Description:Binding affinity for Norepinephrine transporter (NET) expressed in LCK PK1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 29nM ΔG°: -42.6kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
Affinity DataKi: 30nM ΔG°: -42.5kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
Affinity DataKi: 41nM ΔG°: -41.7kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
Affinity DataKi: 47nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
Affinity DataKi: 47nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Pennsylvania
Curated by ChEMBL
University Of Pennsylvania
Curated by ChEMBL
Affinity DataKi: 48.6nMAssay Description:Binding affinity for serotonin transporter expresed in LCK PK1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 52nM ΔG°: -41.2kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
Affinity DataKi: 52nM ΔG°: -41.2kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
Affinity DataKi: 60nM ΔG°: -41.9kJ/mole IC50: 120nMpH: 7.5 T: 2°CAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
Affinity DataKi: 70nM ΔG°: -40.4kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
Affinity DataKi: 112nM ΔG°: -39.3kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University Of Pennsylvania
Curated by ChEMBL
University Of Pennsylvania
Curated by ChEMBL
Affinity DataKi: 112nMAssay Description:Binding affinity for dopamine transporter expressed in LCK PK1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 120nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
Affinity DataKi: 130nM ΔG°: -40.0kJ/mole IC50: 250nMpH: 7.5 T: 2°CAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
Affinity DataKi: 150nM ΔG°: -38.6kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
Affinity DataKi: 165nMAssay Description:Displacement of [3H]-PDBU from protein kinase C-alphaMore data for this Ligand-Target Pair
Affinity DataKi: 170nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
Affinity DataKi: 170nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Pennsylvania
Curated by ChEMBL
University Of Pennsylvania
Curated by ChEMBL
Affinity DataKi: 203nMAssay Description:Binding affinity for serotonin transporter expresed in LCK PK1 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
University Of Pennsylvania
Curated by ChEMBL
University Of Pennsylvania
Curated by ChEMBL
Affinity DataKi: 234nMAssay Description:Binding affinity for Norepinephrine transporter (NET) expressed in LCK PK1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 240nMAssay Description:Displacement of [3H]-PDBU from protein kinase C-alphaMore data for this Ligand-Target Pair