Affinity DataKi: 0.0200nMAssay Description:Inhibition of POP in Han/Wistar rat brain using Suc-Gly-Pro-AMC substrate incubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.0200nMAssay Description:Inhibitory activity against prolyl oligopeptidase of porcine brain homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 0.0230nMAssay Description:Inhibition of pig POPMore data for this Ligand-Target Pair
Affinity DataKi: 0.0230nMAssay Description:Inhibition of prolyl oligopeptidase (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.0300nMAssay Description:Inhibitory activity against prolyl oligopeptidase of porcine brain homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 0.0600nMAssay Description:Inhibitory activity against prolyl oligopeptidase of porcine brain homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 0.0600nMAssay Description:Inhibition of poricne brain POP in expressed in Escherichia coli TOP10 competent cells pre-incubated for 2 hrs before Z-Gly-Pro-AMC substrate additio...More data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Inhibition of porcine prolyl oligopeptidase using Z-Gly-Pro-AMC as substrate after 60 mins by double-reciprocal plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.150nMAssay Description:Inhibitory activity against prolyl oligopeptidase of porcine brain homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 0.210nMAssay Description:Inhibition of bovine brain POPMore data for this Ligand-Target Pair
Affinity DataKi: 0.260nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
Affinity DataKi: 0.280nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
Affinity DataKi: 0.340nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
Affinity DataKi: 0.350nMAssay Description:Inhibition of mouse brain POPMore data for this Ligand-Target Pair
Affinity DataKi: 0.350nMAssay Description:Inhibition of POP in bovine serum using Z-Gly-Pro-NH-Mec fluorimetric substrateMore data for this Ligand-Target Pair
Affinity DataKi: 0.360nMAssay Description:Inhibition of pig brain POPMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Inhibition of recombinant human POP assessed as affinity constant of second step of inhibition pre-incubated for 2 hrs before addition of ZGP-pNA sub...More data for this Ligand-Target Pair
Affinity DataKi: 0.450nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibition of Flavobacterium meningosepticum POPMore data for this Ligand-Target Pair
Affinity DataKi: 0.730nMAssay Description:Competitive inhibition of human PREP using Suc-GP-AMC as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.75nMAssay Description:Inhibition of human POP by tight binding based Morrison equation analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.920nMAssay Description:Inhibition of human POP by tight binding based Morrison equation analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.950nMAssay Description:Inhibition of POP in rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 0.950nMAssay Description:Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate additionMore data for this Ligand-Target Pair
Affinity DataKi: 0.950nMAssay Description:Competitive inhibition of rat brain prolyl oligopeptidaseMore data for this Ligand-Target Pair
Affinity DataKi: 0.970nMAssay Description:Inhibition of prolyl oligopeptidase (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Inhibition of recombinant human POP pre-incubated for 30 mins before addition of ZGP-pNA substrate by absorbance assayMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate additionMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:inhibition of rat cortex POPMore data for this Ligand-Target Pair
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
National Health Research Institutes
Curated by ChEMBL
National Health Research Institutes
Curated by ChEMBL
Affinity DataKi: 1.30nMAssay Description:Competitive inhibition of human recombinant FAP expressed in Hi5 insect cells by Lineweaver-Burke plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Inhibition of human POPMore data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Inhibition of human POP using Z-Gly-Pro-7-AMC substrateMore data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Inhibitory constant against POPMore data for this Ligand-Target Pair
Affinity DataKi: 1.87nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
Affinity DataKi: 2.20nMAssay Description:Inhibition of recombinant POPMore data for this Ligand-Target Pair
Affinity DataKi: 2.20nMAssay Description:Inhibitory constant against POPMore data for this Ligand-Target Pair
Affinity DataKi: 2.30nMAssay Description:Inhibitory constant against POPMore data for this Ligand-Target Pair
Affinity DataKi: 2.40nM Kon: 0.000300M-1s-1 Koff: 1.40E+5s-1Assay Description:Compound was evaluated for the enzyme kinetic data (kon) for binding inhibition against Prolyl Endopeptidase (PEP)More data for this Ligand-Target Pair
Affinity DataKi: 2.40nMAssay Description:Inhibition of mouse brain POPMore data for this Ligand-Target Pair
Affinity DataKi: 2.70nMAssay Description:Inhibitory constant against POPMore data for this Ligand-Target Pair
Affinity DataKi: 2.80nMAssay Description:Inhibitory constant against POPMore data for this Ligand-Target Pair
Affinity DataKi: 3nM Kon: 0.000700M-1s-1 Koff: 2.30E+5s-1Assay Description:Compound was evaluated for the enzyme kinetic data (kon) for binding inhibition against Prolyl Endopeptidase (PEP)More data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Inhibition of mouse recombinant FAP expressed in HEK293 cells using Ala-Pro-p-nitroanilide as substrate incubated for 15 mins prior to substrate addi...More data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Compound was evaluated for binding inhibition against Prolyl Endopeptidase (PEP).More data for this Ligand-Target Pair
Affinity DataKi: 3nM Kon: 0.00200M-1s-1 Koff: 7.00E+5s-1Assay Description:Compound was evaluated for the enzyme kinetic data (kon) for binding inhibition against Prolyl Endopeptidase (PEP)More data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Inhibition of mouse brain POPMore data for this Ligand-Target Pair
Affinity DataKi: 3.30nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
Affinity DataKi: 3.30nMAssay Description:Inhibition of PKD2 ( assessed as residual activity at 1 uM ) by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Inhibition of bovine brain POPMore data for this Ligand-Target Pair