Compile Data Set for Download or QSAR
maximum 50k data
Found 226 of ic50 for UniProtKB: P13726
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50235149(CHEMBL4066780)
Affinity DataIC50:  0.0280nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50235153(CHEBI:67985 | CHEMBL510111)
Affinity DataIC50:  0.0350nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50240379((1E,4E)-1,5-Diphenyl-penta-1,4-dien-3-one | 1,5-di...)
Affinity DataIC50:  0.0530nMAssay Description:Inhibition of tissue factor in Homo sapiens (human) THP1-cells using factor 10a chromogenic substrate assessed as inhibition of LPS-iduced procoagula...More data for this Ligand-Target Pair
In DepthDetails Article
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50235152(CHEBI:4747 | CHEMBL230128)
Affinity DataIC50:  0.0540nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50235142(CHEMBL4070749)
Affinity DataIC50:  0.0780nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50235147(Vitalboside A)
Affinity DataIC50:  0.0950nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50042986((E)-1-(4-Hydroxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of tissue factor in Homo sapiens (human) THP1-cells using factor 10a chromogenic substrate assessed as inhibition of LPS-iduced procoagula...More data for this Ligand-Target Pair
In DepthDetails Article
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50234590(CHEMBL4092579)
Affinity DataIC50:  0.221nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50346613(CHEMBL470029 | Oleanonic Acid)
Affinity DataIC50:  0.221nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50442880(4-Epi-Hederagenin | Hederagenin | US11660306, Exam...)
Affinity DataIC50:  0.221nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50240380(2,6-Bis-(benzylidene)-cyclohexanone | 2,6-Bis-[1-p...)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of tissue factor in Homo sapiens (human) THP1-cells using factor 10a chromogenic substrate assessed as inhibition of LPS-iduced procoagula...More data for this Ligand-Target Pair
In DepthDetails Article
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50235150(CHEBI:67947 | CHEMBL1910843)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50235151(CHEMBL4064877)
Affinity DataIC50:  0.640nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50235148(CHEMBL4062123)
Affinity DataIC50:  0.801nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50264832(2,6-bis(4-hydroxybenzylidene)cyclohexanone | CHEMB...)
Affinity DataIC50:  0.940nMAssay Description:Inhibition of tissue factor in Homo sapiens (human) THP1-cells using factor 10a chromogenic substrate assessed as inhibition of LPS-iduced procoagula...More data for this Ligand-Target Pair
In DepthDetails Article
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50068224((E)-1,3-Bis-(4-hydroxy-phenyl)-propenone | 1,3-bis...)
Affinity DataIC50:  0.960nMAssay Description:Inhibition of tissue factor in Homo sapiens (human) THP1-cells using factor 10a chromogenic substrate assessed as inhibition of LPS-iduced procoagula...More data for this Ligand-Target Pair
In DepthDetails Article
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50235154(CHEMBL4080417)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Laboratory Of Molecular Biology, Medical Research Council

Curated by ChEMBL
LigandPNGBDBM50326044((2S,5S,8R,11S,14S,17S,20S,23S,26R,29S,32S,35S,38S,...)
Affinity DataIC50:  1.5nMAssay Description:Binding affinity to tissue factor/factor 7aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50067044((1E,4E)-1,5-Bis-(4-hydroxy-phenyl)-penta-1,4-dien-...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of tissue factor in Homo sapiens (human) THP1-cells using factor 10a chromogenic substrate assessed as inhibition of LPS-iduced procoagula...More data for this Ligand-Target Pair
In DepthDetails Article
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50424066(CHEMBL2314739)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of tissue factor procoagulant activity in LPS-stimulated human THP1 cells preincubated for 1 hr before LPS addition measured after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50246619((4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-benzyl 10-hyd...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50346601(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Affinity DataIC50:  5nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50235146(CHEMBL4096910)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50424072(CHEMBL2314733 | R-(+)-Tetrahydroberberrubine)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of tissue factor procoagulant activity in LPS-stimulated human THP1 cells preincubated for 1 hr before LPS addition measured after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Laboratory Of Molecular Biology, Medical Research Council

Curated by ChEMBL
LigandPNGBDBM50172214(6-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-(1-m...)
Affinity DataIC50:  8nMAssay Description:Inhibitory concentration against human coagulation factor VIIa/tissue factor cleavage of fluorogenic substrate SN17c at 37 degree C for 15 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50203122(5,8,13,13a-tetrahydro-9,10-dimethoxy-6H-benzo(g)-1...)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of tissue factor procoagulant activity in LPS-stimulated human THP1 cells preincubated for 1 hr before LPS addition measured after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50424063(CHEMBL2314742)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of tissue factor procoagulant activity in LPS-stimulated human THP1 cells preincubated for 1 hr before LPS addition measured after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50235144(CHEMBL3343908)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Laboratory Of Molecular Biology, Medical Research Council

Curated by ChEMBL
LigandPNGBDBM50172213(6-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-(1-m...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against human coagulation factor VIIa/tissue factor cleavage of fluorogenic substrate SN17c at 37 degree C for 15 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50235143(CHEMBL2386940)
Affinity DataIC50:  11nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50424072(CHEMBL2314733 | R-(+)-Tetrahydroberberrubine)
Affinity DataIC50:  12nMAssay Description:Inhibition of tissue factor procoagulant activity in LPS-stimulated human THP1 cells preincubated for 1 hr before LPS addition measured after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50488795(CHEMBL584437 | Go-Y013)
Affinity DataIC50:  13nMAssay Description:Inhibition of tissue factor in Homo sapiens (human) THP1-cells using factor 10a chromogenic substrate assessed as inhibition of LPS-iduced procoagula...More data for this Ligand-Target Pair
In DepthDetails Article
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Laboratory Of Molecular Biology, Medical Research Council

Curated by ChEMBL
LigandPNGBDBM50172227(2-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-(1-m...)
Affinity DataIC50:  13nMAssay Description:Inhibitory concentration against human coagulation factor VIIa/tissue factor cleavage of fluorogenic substrate SN17c at 37 degree C for 15 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataIC50:  13nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50424061(CHEMBL2314744)
Affinity DataIC50:  13nMAssay Description:Inhibition of tissue factor procoagulant activity in LPS-stimulated human THP1 cells preincubated for 1 hr before LPS addition measured after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Laboratory Of Molecular Biology, Medical Research Council

Curated by ChEMBL
LigandPNGBDBM50172227(2-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-(1-m...)
Affinity DataIC50:  13nMAssay Description:Inhibitory concentration against human coagulation factor VIIa/tissue factor cleavage of fluorogenic substrate SN17c at 37 degree C for 15 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Laboratory Of Molecular Biology, Medical Research Council

Curated by ChEMBL
LigandPNGBDBM50172217(6-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-(1-m...)
Affinity DataIC50:  14nMAssay Description:Inhibitory concentration against human coagulation factor VIIa/tissue factor cleavage of fluorogenic substrate SN17c at 37 degree C for 15 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50117993(4,4''-Dimethoxychalcone | 4,4'-DIMETHOXYCHALCONE)
Affinity DataIC50:  15nMAssay Description:Inhibition of tissue factor in Homo sapiens (human) THP1-cells using factor 10a chromogenic substrate assessed as inhibition of LPS-iduced procoagula...More data for this Ligand-Target Pair
In DepthDetails Article
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50170666(2,3,9,10-Tetramethoxy-5,8,13,13a-tetrahydro-6H-iso...)
Affinity DataIC50:  15nMAssay Description:Inhibition of tissue factor procoagulant activity in LPS-stimulated human THP1 cells preincubated for 1 hr before LPS addition measured after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Laboratory Of Molecular Biology, Medical Research Council

Curated by ChEMBL
LigandPNGBDBM50172212(2-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-(1-m...)
Affinity DataIC50:  15nMAssay Description:Inhibitory concentration against human coagulation factor VIIa/tissue factor cleavage of fluorogenic substrate SN17c at 37 degree C for 15 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50235145(CHEMBL3343919)
Affinity DataIC50:  16nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Laboratory Of Molecular Biology, Medical Research Council

Curated by ChEMBL
LigandPNGBDBM14593(3-amino-5-[1-({[(4-carbamimidoylphenyl)methyl]carb...)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant soluble tissue factor (unknown origin)/recombinant human factor 7a using N-methylsulfonyl-D-phe-gly arg-p-nitroaniline as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Laboratory Of Molecular Biology, Medical Research Council

Curated by ChEMBL
LigandPNGBDBM50177187(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant FVIIa/TF complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Laboratory Of Molecular Biology, Medical Research Council

Curated by ChEMBL
LigandPNGBDBM50172225(2-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-(1-m...)
Affinity DataIC50:  16nMAssay Description:Inhibitory concentration against human coagulation factor VIIa/tissue factor cleavage of fluorogenic substrate SN17c at 37 degree C for 15 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Laboratory Of Molecular Biology, Medical Research Council

Curated by ChEMBL
LigandPNGBDBM50177189(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant FVIIa/TF complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Laboratory Of Molecular Biology, Medical Research Council

Curated by ChEMBL
LigandPNGBDBM50172218(6-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-(1-m...)
Affinity DataIC50:  16nMAssay Description:Inhibitory concentration against human coagulation factor VIIa/tissue factor cleavage of fluorogenic substrate SN17c at 37 degree C for 15 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Laboratory Of Molecular Biology, Medical Research Council

Curated by ChEMBL
LigandPNGBDBM50172220(2-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-(1-m...)
Affinity DataIC50:  17nMAssay Description:Inhibitory concentration against human coagulation factor VIIa/tissue factor cleavage of fluorogenic substrate SN17c at 37 degree C for 15 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50424062(CHEMBL2314743)
Affinity DataIC50:  17nMAssay Description:Inhibition of tissue factor procoagulant activity in LPS-stimulated human THP1 cells preincubated for 1 hr before LPS addition measured after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Laboratory Of Molecular Biology, Medical Research Council

Curated by ChEMBL
LigandPNGBDBM50177200(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human recombinant FVIIa/TF complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Laboratory Of Molecular Biology, Medical Research Council

Curated by ChEMBL
LigandPNGBDBM50172232(2-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-(1-m...)
Affinity DataIC50:  17nMAssay Description:Inhibitory concentration against human coagulation factor VIIa/tissue factor cleavage of fluorogenic substrate SN17c at 37 degree C for 15 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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