Compile Data Set for Download or QSAR
Found 101 Enz. Inhib. hit(s) with all data for entry = 50005961
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495750(CHEMBL3113949)
Show SMILES COc1ccc(cc1S(=O)(=O)N(C)C)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C28H28Cl2F2N2O8S/c1-33(2)43(37,38)26-11-18(7-9-23(26)39-3)27(35)41-24(12-19-20(29)13-34(36)14-21(19)30)17-6-8-22(42-28(31)32)25(10-17)40-15-16-4-5-16/h6-11,13-14,16,24,28H,4-5,12,15H2,1-3H3/t24-/m0/s1
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495709(CHEMBL3113966)
Show SMILES Cc1ccc(cc1NS(C)(=O)=O)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C27H26Cl2F2N2O7S/c1-15-3-6-18(9-22(15)32-41(2,36)37)26(34)39-24(11-19-20(28)12-33(35)13-21(19)29)17-7-8-23(40-27(30)31)25(10-17)38-14-16-4-5-16/h3,6-10,12-13,16,24,27,32H,4-5,11,14H2,1-2H3/t24-/m0/s1
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495736(CHEMBL3113948)
Show SMILES CNS(=O)(=O)c1cc(ccc1OC)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C27H26Cl2F2N2O8S/c1-32-42(36,37)25-10-17(6-8-22(25)38-2)26(34)40-23(11-18-19(28)12-33(35)13-20(18)29)16-5-7-21(41-27(30)31)24(9-16)39-14-15-3-4-15/h5-10,12-13,15,23,27,32H,3-4,11,14H2,1-2H3/t23-/m0/s1
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495735(CHEMBL3113954)
Show SMILES CS(=O)(=O)Nc1ccc(cc1CO)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C27H26Cl2F2N2O8S/c1-42(37,38)32-22-6-4-17(8-18(22)13-34)26(35)40-24(10-19-20(28)11-33(36)12-21(19)29)16-5-7-23(41-27(30)31)25(9-16)39-14-15-2-3-15/h4-9,11-12,15,24,27,32,34H,2-3,10,13-14H2,1H3/t24-/m0/s1
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495733(CHEMBL3113962)
Show SMILES Oc1ccc(cc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C29H27Cl2F2NO7/c30-21-12-34(37)13-22(31)20(21)11-25(18-6-8-24(41-29(32)33)27(9-18)39-15-17-3-4-17)40-28(36)19-5-7-23(35)26(10-19)38-14-16-1-2-16/h5-10,12-13,16-17,25,29,35H,1-4,11,14-15H2/t25-/m0/s1
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495710(CHEMBL3113976)
Show SMILES COc1ccc(cc1NS(C)(=O)=O)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C27H26Cl2F2N2O8S/c1-38-22-7-6-17(9-21(22)32-42(2,36)37)26(34)40-24(11-18-19(28)12-33(35)13-20(18)29)16-5-8-23(41-27(30)31)25(10-16)39-14-15-3-4-15/h5-10,12-13,15,24,27,32H,3-4,11,14H2,1-2H3/t24-/m0/s1
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495703(CHEMBL3113943)
Show SMILES COc1ccc(cc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C30H29Cl2F2NO7/c1-38-24-8-7-20(11-27(24)39-15-17-2-3-17)29(36)41-26(12-21-22(31)13-35(37)14-23(21)32)19-6-9-25(42-30(33)34)28(10-19)40-16-18-4-5-18/h6-11,13-14,17-18,26,30H,2-5,12,15-16H2,1H3/t26-/m0/s1
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of PDE4 activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release after 18 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495747(CHEMBL3113968)
Show SMILES COc1ccc(NS(C)(=O)=O)cc1C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C27H26Cl2F2N2O8S/c1-38-22-8-6-17(32-42(2,36)37)10-19(22)26(34)40-24(11-18-20(28)12-33(35)13-21(18)29)16-5-7-23(41-27(30)31)25(9-16)39-14-15-3-4-15/h5-10,12-13,15,24,27,32H,3-4,11,14H2,1-2H3/t24-/m0/s1
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495704(Chf-6001 | Chf6001 | J3.309.618F)
Show SMILES CS(=O)(=O)Nc1ccc(cc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C30H30Cl2F2N2O8S/c1-45(39,40)35-24-8-6-20(11-27(24)41-15-17-2-3-17)29(37)43-26(12-21-22(31)13-36(38)14-23(21)32)19-7-9-25(44-30(33)34)28(10-19)42-16-18-4-5-18/h6-11,13-14,17-18,26,30,35H,2-5,12,15-16H2,1H3/t26-/m0/s1
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495746(CHEMBL3113953)
Show SMILES Cc1cc(ccc1NS(C)(=O)=O)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C27H26Cl2F2N2O7S/c1-15-9-18(5-7-22(15)32-41(2,36)37)26(34)39-24(11-19-20(28)12-33(35)13-21(19)29)17-6-8-23(40-27(30)31)25(10-17)38-14-16-3-4-16/h5-10,12-13,16,24,27,32H,3-4,11,14H2,1-2H3/t24-/m0/s1
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495705(CHEMBL3113964)
Show SMILES OC(=O)c1ccc(cc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C30H27Cl2F2NO8/c31-22-12-35(39)13-23(32)21(22)11-25(18-6-8-24(43-30(33)34)27(9-18)41-15-17-3-4-17)42-29(38)19-5-7-20(28(36)37)26(10-19)40-14-16-1-2-16/h5-10,12-13,16-17,25,30H,1-4,11,14-15H2,(H,36,37)/t25-/m0/s1
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495724(CHEMBL3113950)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C26H24Cl2F2N2O7S/c1-40(35,36)31-18-7-4-16(5-8-18)25(33)38-23(11-19-20(27)12-32(34)13-21(19)28)17-6-9-22(39-26(29)30)24(10-17)37-14-15-2-3-15/h4-10,12-13,15,23,26,31H,2-3,11,14H2,1H3/t23-/m0/s1
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495725(CHEMBL3113946)
Show SMILES COc1ccc(cc1OC(C)=O)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C28H25Cl2F2NO8/c1-15(34)39-26-10-18(6-7-22(26)37-2)27(35)40-24(11-19-20(29)12-33(36)13-21(19)30)17-5-8-23(41-28(31)32)25(9-17)38-14-16-3-4-16/h5-10,12-13,16,24,28H,3-4,11,14H2,1-2H3/t24-/m0/s1
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495703(CHEMBL3113943)
Show SMILES COc1ccc(cc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C30H29Cl2F2NO7/c1-38-24-8-7-20(11-27(24)39-15-17-2-3-17)29(36)41-26(12-21-22(31)13-35(37)14-23(21)32)19-6-9-25(42-30(33)34)28(10-19)40-16-18-4-5-18/h6-11,13-14,17-18,26,30H,2-5,12,15-16H2,1H3/t26-/m0/s1
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495722(CHEMBL3113955)
Show SMILES COc1cc(NS(C)(=O)=O)ccc1C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C27H26Cl2F2N2O8S/c1-38-24-10-17(32-42(2,36)37)6-7-18(24)26(34)40-23(11-19-20(28)12-33(35)13-21(19)29)16-5-8-22(41-27(30)31)25(9-16)39-14-15-3-4-15/h5-10,12-13,15,23,27,32H,3-4,11,14H2,1-2H3/t23-/m0/s1
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495710(CHEMBL3113976)
Show SMILES COc1ccc(cc1NS(C)(=O)=O)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C27H26Cl2F2N2O8S/c1-38-22-7-6-17(9-21(22)32-42(2,36)37)26(34)40-24(11-18-19(28)12-33(35)13-20(18)29)16-5-8-23(41-27(30)31)25(10-16)39-14-15-3-4-15/h5-10,12-13,15,24,27,32H,3-4,11,14H2,1-2H3/t24-/m0/s1
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of PDE4 activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release after 18 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495704(Chf-6001 | Chf6001 | J3.309.618F)
Show SMILES CS(=O)(=O)Nc1ccc(cc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C30H30Cl2F2N2O8S/c1-45(39,40)35-24-8-6-20(11-27(24)41-15-17-2-3-17)29(37)43-26(12-21-22(31)13-36(38)14-23(21)32)19-7-9-25(44-30(33)34)28(10-19)42-16-18-4-5-18/h6-11,13-14,17-18,26,30,35H,2-5,12,15-16H2,1H3/t26-/m0/s1
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of PDE4 activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release after 18 hrs by ELISAMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495723(CHEMBL3113951)
Show SMILES COc1cc(ccc1NS(C)(=O)=O)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C27H26Cl2F2N2O8S/c1-38-24-10-17(5-7-21(24)32-42(2,36)37)26(34)40-23(11-18-19(28)12-33(35)13-20(18)29)16-6-8-22(41-27(30)31)25(9-16)39-14-15-3-4-15/h5-10,12-13,15,23,27,32H,3-4,11,14H2,1-2H3/t23-/m0/s1
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495718(CHEMBL3113967)
Show SMILES CS(=O)(=O)Nc1cc(OCC2CC2)cc(c1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C30H30Cl2F2N2O8S/c1-45(39,40)35-21-8-20(9-22(11-21)41-15-17-2-3-17)29(37)43-27(12-23-24(31)13-36(38)14-25(23)32)19-6-7-26(44-30(33)34)28(10-19)42-16-18-4-5-18/h6-11,13-14,17-18,27,30,35H,2-5,12,15-16H2,1H3/t27-/m0/s1
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495731(CHEMBL3113978)
Show SMILES COc1ccc(cc1OC)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C27H25Cl2F2NO7/c1-35-21-7-6-17(10-24(21)36-2)26(33)38-23(11-18-19(28)12-32(34)13-20(18)29)16-5-8-22(39-27(30)31)25(9-16)37-14-15-3-4-15/h5-10,12-13,15,23,27H,3-4,11,14H2,1-2H3/t23-/m0/s1
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495729(CHEMBL3113937)
Show SMILES [O-][n+]1cc(Cl)c(C[C@H](OC(=O)c2ccccc2)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1
Show InChI InChI=1S/C25H21Cl2F2NO5/c26-19-12-30(32)13-20(27)18(19)11-22(34-24(31)16-4-2-1-3-5-16)17-8-9-21(35-25(28)29)23(10-17)33-14-15-6-7-15/h1-5,8-10,12-13,15,22,25H,6-7,11,14H2/t22-/m0/s1
Affinity DataIC50: 0.0720nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495701(CHEMBL3113947)
Show SMILES COc1ccc(cc1NC(C)=O)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C28H26Cl2F2N2O7/c1-15(35)33-22-9-18(6-7-23(22)38-2)27(36)40-25(11-19-20(29)12-34(37)13-21(19)30)17-5-8-24(41-28(31)32)26(10-17)39-14-16-3-4-16/h5-10,12-13,16,25,28H,3-4,11,14H2,1-2H3,(H,33,35)/t25-/m0/s1
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495719(CHEMBL3113963)
Show SMILES OCc1ccc(cc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C30H29Cl2F2NO7/c31-23-12-35(38)13-24(32)22(23)11-27(19-7-8-25(42-30(33)34)28(9-19)40-16-18-3-4-18)41-29(37)20-5-6-21(14-36)26(10-20)39-15-17-1-2-17/h5-10,12-13,17-18,27,30,36H,1-4,11,14-16H2/t27-/m0/s1
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495726(CHEMBL3113945)
Show SMILES COc1ccc(cc1O)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C26H23Cl2F2NO7/c1-35-21-6-5-16(8-20(21)32)25(33)37-23(10-17-18(27)11-31(34)12-19(17)28)15-4-7-22(38-26(29)30)24(9-15)36-13-14-2-3-14/h4-9,11-12,14,23,26,32H,2-3,10,13H2,1H3/t23-/m0/s1
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495734(CHEMBL3113958)
Show SMILES Nc1ccc(cc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C29H28Cl2F2N2O6/c30-21-12-35(37)13-22(31)20(21)11-25(18-6-8-24(41-29(32)33)27(9-18)39-15-17-3-4-17)40-28(36)19-5-7-23(34)26(10-19)38-14-16-1-2-16/h5-10,12-13,16-17,25,29H,1-4,11,14-15,34H2/t25-/m0/s1
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495738(CHEMBL3113939)
Show SMILES Cc1ccc(cc1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C26H23Cl2F2NO5/c1-15-2-6-17(7-3-15)25(32)35-23(11-19-20(27)12-31(33)13-21(19)28)18-8-9-22(36-26(29)30)24(10-18)34-14-16-4-5-16/h2-3,6-10,12-13,16,23,26H,4-5,11,14H2,1H3/t23-/m0/s1
Affinity DataIC50: 0.100nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495734(CHEMBL3113958)
Show SMILES Nc1ccc(cc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C29H28Cl2F2N2O6/c30-21-12-35(37)13-22(31)20(21)11-25(18-6-8-24(41-29(32)33)27(9-18)39-15-17-3-4-17)40-28(36)19-5-7-23(34)26(10-19)38-14-16-1-2-16/h5-10,12-13,16-17,25,29H,1-4,11,14-15,34H2/t25-/m0/s1
Affinity DataIC50: 0.110nMAssay Description:Inhibition of PDE4 activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release after 18 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495708(CHEMBL3113975)
Show SMILES CS(=O)(=O)Nc1cc(ccc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C30H30Cl2F2N2O8S/c1-45(39,40)35-24-10-20(7-8-25(24)41-15-17-2-3-17)29(37)43-27(12-21-22(31)13-36(38)14-23(21)32)19-6-9-26(44-30(33)34)28(11-19)42-16-18-4-5-18/h6-11,13-14,17-18,27,30,35H,2-5,12,15-16H2,1H3/t27-/m0/s1
Affinity DataIC50: 0.120nMAssay Description:Inhibition of PDE4 activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release after 18 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495731(CHEMBL3113978)
Show SMILES COc1ccc(cc1OC)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C27H25Cl2F2NO7/c1-35-21-7-6-17(10-24(21)36-2)26(33)38-23(11-18-19(28)12-32(34)13-20(18)29)16-5-8-22(39-27(30)31)25(9-16)37-14-15-3-4-15/h5-10,12-13,15,23,27H,3-4,11,14H2,1-2H3/t23-/m0/s1
Affinity DataIC50: 0.120nMAssay Description:Inhibition of PDE4 activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release after 18 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495724(CHEMBL3113950)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C26H24Cl2F2N2O7S/c1-40(35,36)31-18-7-4-16(5-8-18)25(33)38-23(11-19-20(27)12-32(34)13-21(19)28)17-6-9-22(39-26(29)30)24(10-17)37-14-15-2-3-15/h4-10,12-13,15,23,26,31H,2-3,11,14H2,1H3/t23-/m0/s1
Affinity DataIC50: 0.130nMAssay Description:Inhibition of PDE4 activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release after 18 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495702(CHEMBL3113977)
Show SMILES COc1cc(NS(C)(=O)=O)cc(c1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C27H26Cl2F2N2O8S/c1-38-19-8-17(7-18(10-19)32-42(2,36)37)26(34)40-24(11-20-21(28)12-33(35)13-22(20)29)16-5-6-23(41-27(30)31)25(9-16)39-14-15-3-4-15/h5-10,12-13,15,24,27,32H,3-4,11,14H2,1-2H3/t24-/m0/s1
Affinity DataIC50: 0.130nMAssay Description:Inhibition of PDE4 activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release after 18 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495708(CHEMBL3113975)
Show SMILES CS(=O)(=O)Nc1cc(ccc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C30H30Cl2F2N2O8S/c1-45(39,40)35-24-10-20(7-8-25(24)41-15-17-2-3-17)29(37)43-27(12-21-22(31)13-36(38)14-23(21)32)19-6-9-26(44-30(33)34)28(11-19)42-16-18-4-5-18/h6-11,13-14,17-18,27,30,35H,2-5,12,15-16H2,1H3/t27-/m0/s1
Affinity DataIC50: 0.130nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495737(CHEMBL3113942)
Show SMILES COc1ccc(cc1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C26H23Cl2F2NO6/c1-34-18-7-4-16(5-8-18)25(32)36-23(11-19-20(27)12-31(33)13-21(19)28)17-6-9-22(37-26(29)30)24(10-17)35-14-15-2-3-15/h4-10,12-13,15,23,26H,2-3,11,14H2,1H3/t23-/m0/s1
Affinity DataIC50: 0.140nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495711(CHEMBL3113961)
Show SMILES [O-][n+]1cc(Cl)c(C[C@H](OC(=O)c2ccc(NS(=O)(=O)C3CC3)c(OCC3CC3)c2)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1
Show InChI InChI=1S/C32H32Cl2F2N2O8S/c33-24-14-38(40)15-25(34)23(24)13-28(20-6-10-27(46-32(35)36)30(11-20)44-17-19-3-4-19)45-31(39)21-5-9-26(37-47(41,42)22-7-8-22)29(12-21)43-16-18-1-2-18/h5-6,9-12,14-15,18-19,22,28,32,37H,1-4,7-8,13,16-17H2/t28-/m0/s1
Affinity DataIC50: 0.150nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495728(CHEMBL3113938)
Show SMILES [O-][n+]1cc(Cl)c(C[C@H](OC(=O)c2ccc(Cl)cc2)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1
Show InChI InChI=1S/C25H20Cl3F2NO5/c26-17-6-3-15(4-7-17)24(32)35-22(10-18-19(27)11-31(33)12-20(18)28)16-5-8-21(36-25(29)30)23(9-16)34-13-14-1-2-14/h3-9,11-12,14,22,25H,1-2,10,13H2/t22-/m0/s1
Affinity DataIC50: 0.160nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495702(CHEMBL3113977)
Show SMILES COc1cc(NS(C)(=O)=O)cc(c1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C27H26Cl2F2N2O8S/c1-38-19-8-17(7-18(10-19)32-42(2,36)37)26(34)40-24(11-20-21(28)12-33(35)13-22(20)29)16-5-6-23(41-27(30)31)25(9-16)39-14-15-3-4-15/h5-10,12-13,15,24,27,32H,3-4,11,14H2,1-2H3/t24-/m0/s1
Affinity DataIC50: 0.170nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495716(CHEMBL3113970)
Show SMILES CS(=O)(=O)Nc1cccc(C(=O)O[C@@H](Cc2c(Cl)c[n+]([O-])cc2Cl)c2ccc(OC(F)F)c(OCC3CC3)c2)c1OCC1CC1
Show InChI InChI=1S/C30H30Cl2F2N2O8S/c1-45(39,40)35-24-4-2-3-20(28(24)42-16-18-7-8-18)29(37)43-26(12-21-22(31)13-36(38)14-23(21)32)19-9-10-25(44-30(33)34)27(11-19)41-15-17-5-6-17/h2-4,9-11,13-14,17-18,26,30,35H,5-8,12,15-16H2,1H3/t26-/m0/s1
Affinity DataIC50: 0.180nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495727(CHEMBL3113940)
Show SMILES [O-][n+]1cc(Cl)c(C[C@H](OC(=O)c2ccc(cc2)C(F)(F)F)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1
Show InChI InChI=1S/C26H20Cl2F5NO5/c27-19-11-34(36)12-20(28)18(19)10-22(38-24(35)15-3-6-17(7-4-15)26(31,32)33)16-5-8-21(39-25(29)30)23(9-16)37-13-14-1-2-14/h3-9,11-12,14,22,25H,1-2,10,13H2/t22-/m0/s1
Affinity DataIC50: 0.200nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495720(CHEMBL3113960)
Show SMILES CC(=O)Nc1ccc(cc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C31H30Cl2F2N2O7/c1-17(38)36-25-8-6-21(11-28(25)41-15-18-2-3-18)30(39)43-27(12-22-23(32)13-37(40)14-24(22)33)20-7-9-26(44-31(34)35)29(10-20)42-16-19-4-5-19/h6-11,13-14,18-19,27,31H,2-5,12,15-16H2,1H3,(H,36,38)/t27-/m0/s1
Affinity DataIC50: 0.210nMAssay Description:Inhibition of PDE4 activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release after 18 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495745(CHEMBL3113957)
Show SMILES [O-][N+](=O)c1ccc(cc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C29H26Cl2F2N2O8/c30-21-12-34(37)13-22(31)20(21)11-25(18-6-8-24(43-29(32)33)27(9-18)41-15-17-3-4-17)42-28(36)19-5-7-23(35(38)39)26(10-19)40-14-16-1-2-16/h5-10,12-13,16-17,25,29H,1-4,11,14-15H2/t25-/m0/s1
Affinity DataIC50: 0.210nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495713(CHEMBL3113944)
Show SMILES COc1ccc(cc1Oc1ccccc1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C32H27Cl2F2NO7/c1-40-26-11-10-21(14-30(26)42-22-5-3-2-4-6-22)31(38)43-28(15-23-24(33)16-37(39)17-25(23)34)20-9-12-27(44-32(35)36)29(13-20)41-18-19-7-8-19/h2-6,9-14,16-17,19,28,32H,7-8,15,18H2,1H3/t28-/m0/s1
Affinity DataIC50: 0.210nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495748(CHEMBL3113936)
Show SMILES [O-][n+]1cc(Cl)c(C[C@H](OC(=O)c2ccc(OC(F)F)c(OCC3CC3)c2)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1
Show InChI InChI=1S/C30H27Cl2F4NO7/c31-21-12-37(39)13-22(32)20(21)11-25(18-5-7-23(43-29(33)34)26(9-18)40-14-16-1-2-16)42-28(38)19-6-8-24(44-30(35)36)27(10-19)41-15-17-3-4-17/h5-10,12-13,16-17,25,29-30H,1-4,11,14-15H2/t25-/m0/s1
Affinity DataIC50: 0.220nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495720(CHEMBL3113960)
Show SMILES CC(=O)Nc1ccc(cc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C31H30Cl2F2N2O7/c1-17(38)36-25-8-6-21(11-28(25)41-15-18-2-3-18)30(39)43-27(12-22-23(32)13-37(40)14-24(22)33)20-7-9-26(44-31(34)35)29(10-20)42-16-19-4-5-19/h6-11,13-14,18-19,27,31H,2-5,12,15-16H2,1H3,(H,36,38)/t27-/m0/s1
Affinity DataIC50: 0.240nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495736(CHEMBL3113948)
Show SMILES CNS(=O)(=O)c1cc(ccc1OC)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C27H26Cl2F2N2O8S/c1-32-42(36,37)25-10-17(6-8-22(25)38-2)26(34)40-23(11-18-19(28)12-33(35)13-20(18)29)16-5-7-21(41-27(30)31)24(9-16)39-14-15-3-4-15/h5-10,12-13,15,23,27,32H,3-4,11,14H2,1-2H3/t23-/m0/s1
Affinity DataIC50: 0.25nMAssay Description:Inhibition of PDE4 activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release after 18 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495721(CHEMBL3113956)
Show SMILES CS(=O)(=O)Nc1ccc(C(=O)O[C@@H](Cc2c(Cl)c[n+]([O-])cc2Cl)c2ccc(OC(F)F)c(OCC3CC3)c2)c(OCC2CC2)c1
Show InChI InChI=1S/C30H30Cl2F2N2O8S/c1-45(39,40)35-20-7-8-21(27(11-20)41-15-17-2-3-17)29(37)43-26(12-22-23(31)13-36(38)14-24(22)32)19-6-9-25(44-30(33)34)28(10-19)42-16-18-4-5-18/h6-11,13-14,17-18,26,30,35H,2-5,12,15-16H2,1H3/t26-/m0/s1
Affinity DataIC50: 0.260nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495705(CHEMBL3113964)
Show SMILES OC(=O)c1ccc(cc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C30H27Cl2F2NO8/c31-22-12-35(39)13-23(32)21(22)11-25(18-6-8-24(43-30(33)34)27(9-18)41-15-17-3-4-17)42-29(38)19-5-7-20(28(36)37)26(10-19)40-14-16-1-2-16/h5-10,12-13,16-17,25,30H,1-4,11,14-15H2,(H,36,37)/t25-/m0/s1
Affinity DataIC50: 0.300nMAssay Description:Inhibition of PDE4 activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release after 18 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495754(CHEMBL3113959)
Show SMILES CN(C)c1ccc(cc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C31H32Cl2F2N2O6/c1-36(2)25-9-7-21(12-28(25)40-16-18-3-4-18)30(38)42-27(13-22-23(32)14-37(39)15-24(22)33)20-8-10-26(43-31(34)35)29(11-20)41-17-19-5-6-19/h7-12,14-15,18-19,27,31H,3-6,13,16-17H2,1-2H3/t27-/m0/s1
Affinity DataIC50: 0.310nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495749(CHEMBL3113965)
Show SMILES CS(=O)(=O)Nc1cc(ccc1OCc1ccccc1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C33H30Cl2F2N2O8S/c1-48(42,43)38-27-13-23(10-11-28(27)44-18-20-5-3-2-4-6-20)32(40)46-30(15-24-25(34)16-39(41)17-26(24)35)22-9-12-29(47-33(36)37)31(14-22)45-19-21-7-8-21/h2-6,9-14,16-17,21,30,33,38H,7-8,15,18-19H2,1H3/t30-/m0/s1
Affinity DataIC50: 0.320nMAssay Description:Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495711(CHEMBL3113961)
Show SMILES [O-][n+]1cc(Cl)c(C[C@H](OC(=O)c2ccc(NS(=O)(=O)C3CC3)c(OCC3CC3)c2)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1
Show InChI InChI=1S/C32H32Cl2F2N2O8S/c33-24-14-38(40)15-25(34)23(24)13-28(20-6-10-27(46-32(35)36)30(11-20)44-17-19-3-4-19)45-31(39)21-5-9-26(37-47(41,42)22-7-8-22)29(12-21)43-16-18-1-2-18/h5-6,9-12,14-15,18-19,22,28,32,37H,1-4,7-8,13,16-17H2/t28-/m0/s1
Affinity DataIC50: 0.340nMAssay Description:Inhibition of PDE4 activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release after 18 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiesi Farmaceutici S.p.A.

Curated by ChEMBL
LigandPNGBDBM50495723(CHEMBL3113951)
Show SMILES COc1cc(ccc1NS(C)(=O)=O)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1
Show InChI InChI=1S/C27H26Cl2F2N2O8S/c1-38-24-10-17(5-7-21(24)32-42(2,36)37)26(34)40-23(11-18-19(28)12-33(35)13-20(18)29)16-6-8-22(41-27(30)31)25(9-16)39-14-15-3-4-15/h5-10,12-13,15,23,27,32H,3-4,11,14H2,1-2H3/t23-/m0/s1
Affinity DataIC50: 0.380nMAssay Description:Inhibition of PDE4 activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release after 18 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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