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Found 4738 Enz. Inhib. hit(s) with Target = 'Cathepsin D'
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50: 00.0500nMAssay Description:Inhibition of human cathepsin D using GKPILFFRLK(DNP)-D-RNH2) labeled MCA as substrate preincubated for 10 mins followed by substrate addition measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50400214(CHEMBL2181022)
Affinity DataIC50:  0.0783nMAssay Description:Inhibition of recombinant human liver Cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate incubated for 120 mi...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50400214(CHEMBL2181022)
Affinity DataIC50:  0.0783nMAssay Description:Inhibition of cathepsin D by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of secreted cathepsin D in human MDA-MB-231 cells using Mca-Gly-Lys-Pro-Ile-Leu-PhePhe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate pretreated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50400213(CHEMBL2181024)
Affinity DataIC50:  0.126nMAssay Description:Inhibition of cathepsin D by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  0.173nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50603524(CHEMBL5192597)
Affinity DataIC50:  0.178nMAssay Description:Inhibition of recombinant human liver Cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate incubated for 120 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of human liver cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-PhePhe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate pretreated for 15 mins followed b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of human liver cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate preincubated for 15 mins followe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  0.490nMAssay Description:Inhibition of human placenta CatD using Abz-Lys-Pro-Ala-Glu-Phe-Nph-Ala-Leu as substrate preincubated for 10 mins followed by substrate addition and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50377588(CHEMBL257594)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  0.550nMAssay Description:Inhibition of human cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50506541(CHEMBL4576166)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human placenta CatD using Abz-Lys-Pro-Ala-Glu-Phe-Nph-Ala-Leu as substrate preincubated for 10 mins followed by substrate addition and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50312541(((S)-1-[(S)-1-[(1S,2S,4R)-4-((S)-1-Benzylcarbamoyl...)
Affinity DataIC50:  0.630nMAssay Description:Inhibition of human liver cathepsin D after 20 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  0.693nMAssay Description:Inhibition of cathepsin D by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  0.693nMAssay Description:Inhibition of recombinant human liver Cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate incubated for 120 mi...More data for this Ligand-Target Pair
In DepthDetails PubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50080960(2-Bromo-N-[(1S,2S)-3-{[2-(2,4-dichloro-phenyl)-eth...)
Affinity DataIC50:  0.700nMAssay Description:Inhibitory activity against human liver Cathepsin D using Cathepsin D assay.More data for this Ligand-Target Pair
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50437552(CHEMBL2407339)
Affinity DataIC50:  0.840nMAssay Description:Inhibition of Cathepsin D (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50: <1nMAssay Description:Inhibition of Cathepsin D (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Bos taurus)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50022521(Boc-Phe-His-Cha-CH2-S-Leu-NHCO(CH2)2C6H5 | CHEMBL3...)
Affinity DataIC50: >1nMpH: 3.2Assay Description:Inhibition of bovine cathepsin D at pH 3.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50438363(CHEMBL2408751)
Affinity DataIC50:  1nMAssay Description:Inhibition of cathepsin-D (unknown origin) using C-terminal biotinylated peptide substrate treated 30 mins before addition of peptide substrate measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Bos taurus)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50022518(CHEMBL407670 | Pro-His-Pro-Phe-His-Leu-CH2NH-Val-I...)
Affinity DataIC50:  1nMpH: 3.3Assay Description:Inhibition of bovine cathepsin D at pH 3.3(no inhibition)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM232262(US9345742, 20)
Affinity DataIC50:  1nMpH: 5.5 T: 2°CAssay Description:In order to identify modulators of cathepsin D activity, a continuous enzymatic test was carried out with a synthetic peptide which carries a fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50: <1nMAssay Description:Inhibition of cathepsin D (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50294218((3S,14R,16S)-16-((R)-1-hydroxy-2-((S)-6-isopropyl-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50305527((4S)-4-[(1R)-1-hydroxy-2-({1-[3-(1-methylethyl)phe...)
Affinity DataIC50:  1nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50506521(CHEMBL4558691)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human placenta CatD using Abz-Lys-Pro-Ala-Glu-Phe-Nph-Ala-Leu as substrate preincubated for 10 mins followed by substrate addition and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin D(Bos taurus)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50022510(Boc-Phe-His-Leu-CF3-Ile-Amp | CHEMBL154795)
Affinity DataIC50:  1.70nMpH: 3.2Assay Description:Inhibition of human pepsin at pH 3.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50438362(CHEMBL2408752)
Affinity DataIC50:  2nMAssay Description:Inhibition of cathepsin-D (unknown origin) using C-terminal biotinylated peptide substrate treated 30 mins before addition of peptide substrate measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against human liver Cathepsin D using Cathepsin D assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50383837(CHEMBL2030998)
Affinity DataIC50:  2nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50437542(CHEMBL2407492)
Affinity DataIC50:  2nMAssay Description:Inhibition of Cathepsin D (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  2.33nMAssay Description:Inhibition of cathepsin D (unknown origin) using hemoglobin as substrate after 30 min by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticleMMDB

TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50506530(CHEMBL4514021)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human placenta CatD using Abz-Lys-Pro-Ala-Glu-Phe-Nph-Ala-Leu as substrate preincubated for 10 mins followed by substrate addition and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50305536((S)-4-{(R)-1-Hydroxy-2-[1-(3-isopropyl-phenyl)-cyc...)
Affinity DataIC50:  3nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50383839(CHEMBL2030997)
Affinity DataIC50:  3nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50506516(CHEMBL4444244)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of human placenta CatD using Abz-Lys-Pro-Ala-Glu-Phe-Nph-Ala-Leu as substrate preincubated for 10 mins followed by substrate addition and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM232279(US9345742, 37)
Affinity DataIC50:  3.20nMpH: 5.5 T: 2°CAssay Description:In order to identify modulators of cathepsin D activity, a continuous enzymatic test was carried out with a synthetic peptide which carries a fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50302846(CHEMBL570165 | benzyl 3-((2R,3S)-3-acetamido-4-(3,...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of cathepsin D assessed as reduction in polarization after 110 mins by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50506535(CHEMBL4560400)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of human placenta CatD using Abz-Lys-Pro-Ala-Glu-Phe-Nph-Ala-Leu as substrate preincubated for 10 mins followed by substrate addition and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM232284(US9345742, 42)
Affinity DataIC50:  3.60nMpH: 5.5 T: 2°CAssay Description:In order to identify modulators of cathepsin D activity, a continuous enzymatic test was carried out with a synthetic peptide which carries a fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM232270(US9345742, 28)
Affinity DataIC50:  3.70nMpH: 5.5 T: 2°CAssay Description:In order to identify modulators of cathepsin D activity, a continuous enzymatic test was carried out with a synthetic peptide which carries a fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50506522(CHEMBL4532529)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of human placenta CatD using Abz-Lys-Pro-Ala-Glu-Phe-Nph-Ala-Leu as substrate preincubated for 10 mins followed by substrate addition and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM232261(US9345742, 19)
Affinity DataIC50:  3.90nMpH: 5.5 T: 2°CAssay Description:In order to identify modulators of cathepsin D activity, a continuous enzymatic test was carried out with a synthetic peptide which carries a fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50555173(CHEMBL4754691)
Affinity DataIC50:  4nMAssay Description:Inhibition of human liver Cathepsin D preincubated for 10 mins followed by substrate addition and further incubated for 2 hrs in dark by fluorimetric...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50383838(CHEMBL2030996)
Affinity DataIC50:  4nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Bos taurus)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50022510(Boc-Phe-His-Leu-CF3-Ile-Amp | CHEMBL154795)
Affinity DataIC50:  4nMpH: 3.2Assay Description:Inhibition of bovine cathepsin D at pH 3.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50383846(CHEMBL2031142)
Affinity DataIC50:  4nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM232275(US9345742, 33)
Affinity DataIC50:  4.10nMpH: 5.5 T: 2°CAssay Description:In order to identify modulators of cathepsin D activity, a continuous enzymatic test was carried out with a synthetic peptide which carries a fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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