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Reaction Details
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TargetDopamine receptor
LigandBDBM50099821
Substrate/Competitorn/a
Meas. Tech.ChEMBL_62749
Ki 0.04±n/a nM
Citation Huang, YLuedtke, RRFreeman, RAWu, LMach, RH Synthesis and structure-activity relationships of naphthamides as dopamine D3 receptor ligands. J Med Chem44:1815-26 (2001) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dopamine receptor
Name:Dopamine receptor D2 and D3
Synonyms:D(3) dopamine receptor | DOPAMINE D3 | DRD3 | Dopamine D3 receptor
Type:Protein
Mol. Mass.:49540.58
Organism:Rattus norvegicus (Rat)
Description:P19020
Residue:446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSI
CSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQ
QSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLK
RYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGP
LQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYV
NSALNPVIYTTFNVEFRKAFLKILSC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50099821
NameBDBM50099821
Synonyms:4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (9-benzyl-9-aza-bicyclo[3.3.1]non-3-yl)-amide | CHEMBL52588
TypeSmall organic molecule
Emp. Form.C27H29BrN2O2
Mol. Mass.493.435
SMILESCOc1c(cc(Br)c2ccccc12)C(=O)NC1CC2CCCC(C1)N2Cc1ccccc1 |THB:15:16:24:19.21.20,25:24:16.17.23:19.21.20|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a