Reaction Details Report a problem with these data
Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50181223
Substrate
n/a
Meas. Tech.
ChEMBL_345662 (CHEMBL870659)
IC50
38±n/a nM
Citation
 Liu, B; Liu, M; Xin, Z; Zhao, H; Serby, MD; Kosogof, C; Nelson, LT; Szczepankiewicz, BG; Kaszubska, W; Schaefer, VG; Falls, HD; Lin, CW; Collins, CA; Sham, HL; Liu, G Optimization of 2,4-diaminopyrimidines as GHS-R antagonists: side chain exploration. Bioorg Med Chem Lett 16:1864-8 (2006) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50181223
Synonyms:
5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-((pyridin-3-ylmethoxy)methyl)pyrimidine-2,4-diamine | CHEMBL382853
Type:
Small organic molecule
Emp. Form.:
C25H26N6O3S
Mol. Mass.:
490.577
SMILES:
CS(=O)(=O)c1ccc(CNc2ccc(cc2)-c2c(N)nc(N)nc2COCc2cccnc2)cc1
Structure:
Search PDB for entries with ligand similarity: