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Target
Proteasome subunit beta type-4
Ligand
BDBM50185624
Substrate
n/a
Meas. Tech.
ChEMBL_361597 (CHEMBL859725)
Ki
78000±n/a nM
Citation
 Basse, N; Papapostolou, D; Pagano, M; Reboud-Ravaux, M; Bernard, E; Felten, AS; Vanderesse, R Development of lipopeptides for inhibiting 20S proteasomes. Bioorg Med Chem Lett 16:3277-81 (2006) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-4
Synonyms:
PRE1 | PSB4_YEAST | Proteasome Macropain subunit
Type:
PROTEIN
Mol. Mass.:
22515.40
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_361597
Residue:
198
Sequence:
MDIILGIRVQDSVILASSKAVTRGISVLKDSDDKTRQLSPHTLMSFAGEAGDTVQFAEYIQANIQLYSIREDYELSPQAVSSFVRQELAKSIRSRRPYQVNVLIGGYDKKKNKPELYQIDYLGTKVELPYGAHGYSGFYTFSLLDHHYRPDMTTEEGLDLLKLCVQELEKRMPMDFKGVIVKIVDKDGIRQVDDFQAQ
  
Inhibitor
Name:
BDBM50185624
Synonyms:
(S)-4-((S)-1-carboxy-2-(4-hydroxyphenyl)ethylamino)-3-((S)-2-((2S,3R)-3-hydroxy-2-((2S,3S)-2-((2S,3R)-3-hydroxy-2-tetradecanamidobutanamido)-3-methylpentanamido)butanamido)-3-phenylpropanamido)-4-oxobutanoic acid | CHEMBL209196
Type:
Small organic molecule
Emp. Form.:
C50H76N6O13
Mol. Mass.:
969.1708
SMILES:
CCCCCCCCCCCCCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Structure:
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