Reaction Details Report a problem with these data
Target
Disintegrin and metalloproteinase domain-containing protein 17
Ligand
BDBM50325008
Substrate
n/a
Meas. Tech.
ChEMBL_651587 (CHEMBL1227970)
Ki
0.5±n/a nM
Citation
Yu, W; Tong, L; Kim, SH; Wong, MK; Chen, L; Yang, DY; Shankar, BB; Lavey, BJ; Zhou, G; Kosinski, A; Rizvi, R; Li, D; Feltz, RJ; Piwinski, JJ; Rosner, KE; Shih, NY; Siddiqui, MA; Guo, Z; Orth, P; Shah, H; Sun, J; Umland, S; Lundell, DJ; Niu, X; Kozlowski, JA Biaryl substituted hydantoin compounds as TACE inhibitors. Bioorg Med Chem Lett 20:5286-9 (2010) [PubMed] Article
More Info.:
Target
Name:
Disintegrin and metalloproteinase domain-containing protein 17
Synonyms:
ADA17_HUMAN | ADAM17 | CSVP | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM-17) | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) | TACE | TNF-alpha convertase | TNF-alpha converting enzyme (TACE) | TNF-alpha-converting enzyme (TACE) | Tumor Necrosis Factor Alpha Converting Enzyme | Tumor necrosis factor-α converting enzyme (TACE)
Type:
Enzyme
Mol. Mass.:
93007.89
Organism:
Homo sapiens (Human)
Description:
Residue:
824
Sequence:
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQSPKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMDSASVRIIKPFPAPQTPGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVDSKETEC
Inhibitor
Name:
BDBM50325008
Synonyms:
(R)-5-(4-(3,5-dimethylisoxazol-4-yl)phenyl)-5-((6-fluoro-1-oxoisoindolin-2-yl)methyl)imidazolidine-2,4-dione | CHEMBL1223006
Type:
Small organic molecule
Emp. Form.:
C23H19FN4O4
Mol. Mass.:
434.4198
SMILES:
Cc1noc(C)c1-c1ccc(cc1)[C@]1(CN2Cc3ccc(F)cc3C2=O)NC(=O)NC1=O |r|