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Target
Kappa-type opioid receptor
Ligand
BDBM50272038
Substrate
n/a
Meas. Tech.
ChEMBL_145851 (CHEMBL756114)
IC50
999±n/a nM
Citation
 Houghten, RA; Pinilla, C; Appel, JR; Blondelle, SE; Dooley, CT; Eichler, J; Nefzi, A; Ostresh, JM Mixture-based synthetic combinatorial libraries. J Med Chem 42:3743-78 (1999) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50272038
Synonyms:
(2R,5S)-5-cyclohexyl-1-[(4-methylcyclohexyl)methyl]-2-(2-methylpropyl)-1H,2H,3H,5H,6H-imidazo[1,2-a]imidazolidin-7-ium
Type:
Small organic molecule
Emp. Form.:
C23H42N3
Mol. Mass.:
360.5991
SMILES:
CC(C)CC1C[N+]2=C(NCC2C2CCCCC2)N1CC1CCC(C)CC1 |t:6,(18.78,-19.11,;17.24,-19.08,;16.51,-17.72,;16.44,-20.39,;14.9,-20.35,;14.03,-19.08,;12.56,-19.52,;12.51,-21.07,;11.03,-21.5,;10.15,-20.23,;11.1,-19,;10.66,-17.53,;11.71,-16.42,;11.28,-14.94,;9.78,-14.58,;8.72,-15.69,;9.15,-17.17,;13.96,-21.58,;14.4,-23.06,;13.34,-24.18,;11.85,-23.81,;10.79,-24.92,;11.23,-26.4,;10.16,-27.51,;12.72,-26.76,;13.79,-25.65,)|
Structure:
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