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Found 767 with Last Name = 'appel' and Initial = 'jr'
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Torrey Pines Institute For Molecular Studies

Curated by ChEMBL
LigandPNGBDBM50369460(CHEMBL1788109)
Affinity DataKi:  0.160nMAssay Description:Enzyme inhibitory activity towards Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399749(CHEMBL2179430)
Affinity DataKi:  0.340nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399753(CHEMBL2179835)
Affinity DataKi:  0.400nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50266734(CHEMBL4096081)
Affinity DataKi:  0.790nMAssay Description:Antagonist activity at human MC4R expressed in CHO cells assessed as inhibition of aplha MSH-induced cAMP activation after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399754(CHEMBL2179836)
Affinity DataKi:  1.10nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399752(CHEMBL2179429)
Affinity DataKi:  1.30nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399754(CHEMBL2179836)
Affinity DataKi:  1.40nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399753(CHEMBL2179835)
Affinity DataKi:  1.70nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399751(CHEMBL2179431)
Affinity DataKi:  2nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399752(CHEMBL2179429)
Affinity DataKi:  2.90nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399751(CHEMBL2179431)
Affinity DataKi:  5.30nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399750(CHEMBL2179428)
Affinity DataKi:  7nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399750(CHEMBL2179428)
Affinity DataKi:  9nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399749(CHEMBL2179430)
Affinity DataKi:  12.4nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Mus musculus)
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50266704(CHEMBL4083717)
Affinity DataKi:  15nMAssay Description:Antagonist activity at mouse MC4R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399748(CHEMBL2179434)
Affinity DataKi:  18nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399747(CHEMBL2179832)
Affinity DataKi:  19nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399746(CHEMBL2179435)
Affinity DataKi:  22nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399761(CHEMBL2179833)
Affinity DataKi:  23nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399759(CHEMBL2179436)
Affinity DataKi:  70nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Mus musculus)
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50266713(CHEMBL4089759)
Affinity DataKi:  126nMAssay Description:Antagonist activity at mouse MC4R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50387003(CHEMBL2049156)
Affinity DataKi:  240nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399756(CHEMBL2179437)
Affinity DataKi:  300nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399748(CHEMBL2179434)
Affinity DataKi:  400nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399746(CHEMBL2179435)
Affinity DataKi:  430nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399747(CHEMBL2179832)
Affinity DataKi:  480nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399761(CHEMBL2179833)
Affinity DataKi:  500nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50387003(CHEMBL2049156)
Affinity DataKi:  900nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399760(CHEMBL2179427)
Affinity DataKi: >1.00E+3nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399759(CHEMBL2179436)
Affinity DataKi:  1.00E+3nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399760(CHEMBL2179427)
Affinity DataKi: >1.00E+3nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399757(CHEMBL2179433)
Affinity DataKi:  1.20E+3nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399758(CHEMBL2179432)
Affinity DataKi:  1.30E+3nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399755(CHEMBL2179438)
Affinity DataKi:  1.38E+3nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399758(CHEMBL2179432)
Affinity DataKi:  1.60E+3nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399757(CHEMBL2179433)
Affinity DataKi:  1.60E+3nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399755(CHEMBL2179438)
Affinity DataKi:  2.60E+3nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399756(CHEMBL2179437)
Affinity DataKi:  4.10E+3nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Institute For Molecular Studies

Curated by ChEMBL
LigandPNGBDBM50188149(4-[(2S)-2-(dimethylamino)-3-{[(2S)-1-(4-hydroxyphe...)
Affinity DataIC50:  0.5nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Mus musculus)
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50017181(CHEMBL441738)
Affinity DataIC50:  2nMAssay Description:Displacement of [125I]-NDP-MSH from mouse MC4R expressed in HEK293 cells after 1 hr by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Institute For Molecular Studies

Curated by ChEMBL
LigandPNGBDBM50188156(4-[(2S)-3-{[(2S)-1-(4-hydroxyphenyl)-3-{methyl[(2S...)
Affinity DataIC50:  2nMAssay Description:Antagonist activity against mu opioid receptor in guinea-pig ileum assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Institute For Molecular Studies

Curated by ChEMBL
LigandPNGBDBM50188168(4-[(2S)-3-{[(2S)-1-(benzylamino)-3-(4-hydroxypheny...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Mus musculus)
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50017181(CHEMBL441738)
Affinity DataIC50:  5.30nMAssay Description:Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Institute For Molecular Studies

Curated by ChEMBL
LigandPNGBDBM50188167(4-[(2S)-2-amino-3-{[(2S)-1-{[(2S)-1-[(2S)-2-(amino...)
Affinity DataIC50:  6nMAssay Description:Antagonist activity against mu opioid receptor in guinea-pig ileum assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Institute For Molecular Studies

Curated by ChEMBL
LigandPNGBDBM50188203(4-[(2S)-2-(dimethylamino)-3-{[(2S)-1-(4-hydroxyphe...)
Affinity DataIC50:  8nMAssay Description:Antagonist activity against mu opioid receptor in guinea-pig ileum assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Institute For Molecular Studies

Curated by ChEMBL
LigandPNGBDBM50188209(4-[(2S)-2-amino-3-{[(2S)-1-(benzylamino)-3-(4-hydr...)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Institute For Molecular Studies

Curated by ChEMBL
LigandPNGBDBM50188210(4-[(2S)-2-amino-3-{[(2S)-1-(4-hydroxyphenyl)-3-{me...)
Affinity DataIC50:  13nMAssay Description:Antagonist activity against mu opioid receptor in guinea-pig ileum assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Institute For Molecular Studies

Curated by ChEMBL
LigandPNGBDBM50188217(4-[(2S)-3-{[(2S)-1-{[(2S)-1-[(2S)-2-(aminomethyl)p...)
Affinity DataIC50:  13nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Mus musculus)
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50266704(CHEMBL4083717)
Affinity DataIC50:  13nMAssay Description:Displacement of [125I]-NDP-MSH from mouse MC4R expressed in HEK293 cells after 1 hr by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Institute For Molecular Studies

Curated by ChEMBL
LigandPNGBDBM50298862(4-((S)-3-(methylamino)-2-((R)-2-((4-methylcyclohex...)
Affinity DataIC50:  14nMAssay Description:Displacement of [3H]U69593 from guinea pig kappa opioid receptor by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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