TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Torrey Pines Institute For Molecular Studies
Curated by ChEMBL
Torrey Pines Institute For Molecular Studies
Curated by ChEMBL
Affinity DataKi: 0.160nMAssay Description:Enzyme inhibitory activity towards Angiotensin I converting enzymeMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 0.340nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 0.400nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
Affinity DataKi: 0.790nMAssay Description:Antagonist activity at human MC4R expressed in CHO cells assessed as inhibition of aplha MSH-induced cAMP activation after 45 minsMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 1.10nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 1.30nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
Affinity DataKi: 1.40nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
Affinity DataKi: 1.70nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 2nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
Affinity DataKi: 2.90nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
Affinity DataKi: 5.30nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 7nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
Affinity DataKi: 9nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
Affinity DataKi: 12.4nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Antagonist activity at mouse MC4R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen a...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 18nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 19nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 22nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 23nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 70nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
Affinity DataKi: 126nMAssay Description:Antagonist activity at mouse MC4R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen a...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 240nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 300nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
Affinity DataKi: 400nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
Affinity DataKi: 430nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
Affinity DataKi: 480nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
Affinity DataKi: 500nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
Affinity DataKi: 900nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
Affinity DataKi: 1.00E+3nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
Affinity DataKi: 1.20E+3nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
Affinity DataKi: 1.30E+3nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 1.38E+3nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 1.60E+3nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 1.60E+3nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
Affinity DataKi: 2.60E+3nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
Affinity DataKi: 4.10E+3nMpH: 7.5Assay Description:Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Institute For Molecular Studies
Curated by ChEMBL
Institute For Molecular Studies
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Displacement of [125I]-NDP-MSH from mouse MC4R expressed in HEK293 cells after 1 hr by gamma countingMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Antagonist activity against mu opioid receptor in guinea-pig ileum assayMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Institute For Molecular Studies
Curated by ChEMBL
Institute For Molecular Studies
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataIC50: 5.30nMAssay Description:Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Antagonist activity against mu opioid receptor in guinea-pig ileum assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Antagonist activity against mu opioid receptor in guinea-pig ileum assayMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Institute For Molecular Studies
Curated by ChEMBL
Institute For Molecular Studies
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Antagonist activity against mu opioid receptor in guinea-pig ileum assayMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Institute For Molecular Studies
Curated by ChEMBL
Institute For Molecular Studies
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Displacement of [125I]-NDP-MSH from mouse MC4R expressed in HEK293 cells after 1 hr by gamma countingMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Institute For Molecular Studies
Curated by ChEMBL
Institute For Molecular Studies
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Displacement of [3H]U69593 from guinea pig kappa opioid receptor by liquid scintillation countingMore data for this Ligand-Target Pair