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Target
Sodium- and chloride-dependent glycine transporter 2
Ligand
BDBM50188845
Substrate
n/a
Meas. Tech.
ChEMBL_379379 (CHEMBL864836)
EC50
>30000±n/a nM
Citation
 Alberati, D; Hainzl, D; Jolidon, S; Kurt, A; Pinard, E; Thomas, AW; Zimmerli, D 4-Substituted-8-(1-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with superior pharmacological and pharmacokinetic parameters. Bioorg Med Chem Lett 16:4321-5 (2006) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent glycine transporter 2
Synonyms:
GLYT2 | Glycine transporter 2 | NET1 | SC6A5_HUMAN | SLC6A5 | Sodium- and chloride-dependent glycine transporter 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
87438.56
Organism:
Homo sapiens (Human)
Description:
Glycine-2-transporter 0 HUMAN::Q9Y345
Residue:
797
Sequence:
MDCSAPKEMNKLPANSPEAAAAQGHPDGPCAPRTSPEQELPAAAAPPPPRVPRSASTGAQTFQSADARACEAERPGVGSCKLSSPRAQAASAALRDLREAQGAQASPPPGSSGPGNALHCKIPFLRGPEGDANVSVGKGTLERNNTPVVGWVNMSQSTVVLATDGITSVLPGSVATVATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTSSLGLKLPVKDLELGTQC
  
Inhibitor
Name:
BDBM50188845
Synonyms:
4-(4-fluoro-phenyl)-8-(1-m-tolyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one | CHEMBL209380 | rac-4-(4-fluoro-phenyl)-8-(1-m-tolyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one
Type:
Small organic molecule
Emp. Form.:
C27H33FN2O
Mol. Mass.:
420.5621
SMILES:
Cc1cccc(c1)C1(CCCCC1)N1CCC2(CC1)C(CNC2=O)c1ccc(F)cc1
Structure:
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