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Target
Low molecular weight phosphotyrosine protein phosphatase
Ligand
BDBM50214527
Substrate
n/a
Meas. Tech.
ChEMBL_448046 (CHEMBL898301)
IC50
2500±n/a nM
Citation
 Maccari, R; Paoli, P; Ottanà, R; Jacomelli, M; Ciurleo, R; Manao, G; Steindl, T; Langer, T; Vigorita, MG; Camici, G 5-Arylidene-2,4-thiazolidinediones as inhibitors of protein tyrosine phosphatases. Bioorg Med Chem 15:5137-49 (2007) [PubMed]  Article 
Target
Name:
Low molecular weight phosphotyrosine protein phosphatase
Synonyms:
3.1.3.2 | 3.1.3.48 | ACP1 | Adipocyte acid phosphatase | LMW-PTP | LMW-PTPase | LMWPTP | Low molecular weight cytosolic acid phosphatase | PPAC_HUMAN | Red cell acid phosphatase 1 | low molecular weight phosphotyrosine protein phosphatase isoform c
Type:
n/a
Mol. Mass.:
18042.81
Organism:
Homo sapiens (Human)
Description:
P24666
Residue:
158
Sequence:
MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGSYDPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH
  
Inhibitor
Name:
BDBM50214527
Synonyms:
4-((5-(4-(benzyloxy)benzylidene)-2,4-dioxothiazolidin-3-yl)methyl)benzoic acid | 4-[5-(4-benzyloxybenzylidene)-2,4-dioxothiazolidin-3-yl]methylbenzoic acid | CHEMBL235595
Type:
Small organic molecule
Emp. Form.:
C25H19NO5S
Mol. Mass.:
445.487
SMILES:
OC(=O)c1ccc(CN2C(=O)S\C(=C/c3ccc(OCc4ccccc4)cc3)C2=O)cc1
Structure:
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