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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50303929
Substrate
n/a
Meas. Tech.
ChEMBL_595171 (CHEMBL1040013)
IC50
5000±n/a nM
Citation
 Röhrig, UF; Awad, L; Grosdidier, A; Larrieu, P; Stroobant, V; Colau, D; Cerundolo, V; Simpson, AJ; Vogel, P; Van den Eynde, BJ; Zoete, V; Michielin, O Rational design of indoleamine 2,3-dioxygenase inhibitors. J Med Chem 53:1172-89 (2010) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50303929
Synonyms:
CHEMBL576124 | N-(4-Hydroxy-1-naphthyl)propane-1,3-diaminium Chloride
Type:
Small organic molecule
Emp. Form.:
C13H16N2O
Mol. Mass.:
216.2789
SMILES:
NCCCNc1ccc(O)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: