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Target
Acid ceramidase
Ligand
BDBM50151154
Substrate
n/a
Meas. Tech.
ChEBML_1558880
IC50
390±n/a nM
Citation
 Nuzzi, A; Fiasella, A; Ortega, JA; Pagliuca, C; Ponzano, S; Pizzirani, D; Bertozzi, SM; Ottonello, G; Tarozzo, G; Reggiani, A; Bandiera, T; Bertozzi, F; Piomelli, D Potenta-amino-ß-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure-activity relationship (SAR) studies. Eur J Med Chem 111:138-59 (2016) [PubMed]  Article 
Target
Name:
Acid ceramidase
Synonyms:
ASAH | ASAH1 | ASAH1_HUMAN | Acid ceramidase | Acid ceramidase (AC)
Type:
Enzyme
Mol. Mass.:
44662.65
Organism:
Homo sapiens (Human)
Description:
Q13510
Residue:
395
Sequence:
MPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIAAVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTKPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW
  
Inhibitor
Name:
BDBM50151154
Synonyms:
CHEMBL3770896
Type:
Small organic molecule
Emp. Form.:
C15H20N2O3
Mol. Mass.:
276.3309
SMILES:
CCCCc1ccc(COC(=O)N[C@H]2CNC2=O)cc1 |r|
Structure:
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