Compile Data Set for Download or QSAR
Report error Found 8271 for UniProtKB: O75116
TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM50311409(N-((6R,9R,12R,15R,18R,21R,31R)-1-amino-31-(4-amino...)
Affinity DataKd:  0.00560nMAssay Description:Displacement of fluorescent-ARC-1063 from His6-tagged recombinant human ROCK2 by luminescence intensity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM50382219(CHEMBL2023843)
Affinity DataKd:  0.0200nMAssay Description:Displacement of fluorescent-ARC-1063 from His6-tagged recombinant human ROCK2 by luminescence intensity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM27227((2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-pu...)
Affinity DataKd:  0.0210nMAssay Description:Displacement of fluorescent-ARC-1063 from His6-tagged recombinant human ROCK2 by luminescence intensity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM27227((2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-pu...)
Affinity DataKd:  0.0210nMAssay Description:Displacement of fluorescent-ARC-1063 from His6-tagged recombinant human ROCK2 by luminescence intensity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598601(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N-(1H-indazo...)
Affinity DataIC50: 0.100nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598664(US11613531, Example 342 | Ethyl 2-(3,8-diazabicycl...)
Affinity DataIC50: 0.100nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598596(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-N-(1H-indaz...)
Affinity DataIC50: 0.100nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM119907(US8697911, 30)
Affinity DataIC50: 0.160nMpH: 7.2Assay Description:This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM119936(US8697911, 78)
Affinity DataIC50: 0.170nMpH: 7.2Assay Description:This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM50410642(CHEMBL5287722)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM119953(US8697911, 112)
Affinity DataIC50: 0.180nMpH: 7.2Assay Description:This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM376441(6-ethyl-N-[(1R)-1-(3- methoxyphenyl)ethyl]- 6H-is...)
Affinity DataIC50: 0.180nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM50089584(CHEMBL3578252 | US9914740, VIII-15)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of ROCK2 (unknown origin) using substrate FITC-AHA- AKRRRLSSLRA-OHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM252176(US9458110, 248)
Affinity DataIC50: 0.190nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM119965(US8697911, 129 | US10738007, Compound B | US115550...)
Affinity DataIC50: 0.195nMpH: 7.2Assay Description:This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM50632492(CHEMBL5397091)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM50156774(CHEMBL3792888)
Affinity DataKi:  0.200nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2017
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM50634347(CHEMBL5414146)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of ROCK2 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM120005(US8697911, 207)
Affinity DataIC50: 0.200nMpH: 7.2Assay Description:This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM119970(US8697911, 136)
Affinity DataIC50: 0.200nMpH: 7.2Assay Description:This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM50546246(CHEMBL4753043 | US11608319, Compound AR-13503)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human ROCK2 expressed in baculovirus expression system by Kinase-Glo luminescent AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM50382224(CHEMBL2023841)
Affinity DataKd: <0.200nMAssay Description:Binding affinity to His6-tagged recombinant human ROCK2 by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM50546246(CHEMBL4753043 | US11608319, Compound AR-13503)
Affinity DataKi:  0.200nMAssay Description:Inhibition of recombinant human GST-tagged ROCK2 catalytic domain expressed in baculovirus expression system by Kinase-Glo luminescent kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM50546246(CHEMBL4753043 | US11608319, Compound AR-13503)
Affinity DataKi:  0.200nMAssay Description:Inhibition of Rock2 (unknown origin) by Kinase Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM50382217(CHEMBL2023845)
Affinity DataKd: <0.200nMAssay Description:Binding affinity to His6-tagged recombinant human ROCK2 by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM119896(US8697911, 12)
Affinity DataIC50: 0.210nMpH: 7.2Assay Description:This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM376380(US9914740, VIII-6 | N-((R)-1-(3-methoxyphenyl) eth...)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of ROCK2 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM119971(US8697911, 138)
Affinity DataIC50: 0.210nMpH: 7.2Assay Description:This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM119957(US8697911, 119)
Affinity DataIC50: 0.220nMpH: 7.2Assay Description:This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM119966(US8697911, 130)
Affinity DataIC50: 0.220nMpH: 7.2Assay Description:This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM119950(US8697911, 106)
Affinity DataIC50: 0.220nMpH: 7.2Assay Description:This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM457032(US10738007, Compound ID 98 | US11555039, Compound ...)
Affinity DataIC50: 0.230nMAssay Description:n general, kinases regulate many important cellular activities including cell growth, signaling, metabolism, etc. Different kinases have distinct fun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM457032(US10738007, Compound ID 98 | US11555039, Compound ...)
Affinity DataIC50: 0.230nMAssay Description:The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM119934(US8697911, 74)
Affinity DataIC50: 0.230nMpH: 7.2Assay Description:This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM252174(US9458110, 246)
Affinity DataIC50: 0.230nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM119969(US8697911, 134)
Affinity DataIC50: 0.240nMpH: 7.2Assay Description:This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  0.240nMAssay Description:Binding constant for ROCK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.246nMAssay Description:Inhibition of human ROCK2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM120004(US8697911, 205)
Affinity DataIC50: 0.25nMpH: 7.2Assay Description:This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM457033(US10738007, Compound ID 101 | US11555039, Compound...)
Affinity DataIC50: 0.25nMAssay Description:n general, kinases regulate many important cellular activities including cell growth, signaling, metabolism, etc. Different kinases have distinct fun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM457033(US10738007, Compound ID 101 | US11555039, Compound...)
Affinity DataIC50: 0.25nMAssay Description:The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM119933(US8697911, 70)
Affinity DataIC50: 0.25nMpH: 7.2Assay Description:This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM119938(US8697911, 84)
Affinity DataIC50: 0.260nMpH: 7.2Assay Description:This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM119926(US8697911, 56)
Affinity DataIC50: 0.260nMpH: 7.2Assay Description:This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM119963(US8697911, 126)
Affinity DataIC50: 0.270nMpH: 7.2Assay Description:This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM119946(US8697911, 98)
Affinity DataIC50: 0.270nMpH: 7.2Assay Description:This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM252182(US9458110, 254)
Affinity DataIC50: 0.280nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM456973(US10738007, Compound ID 39 | US11555039, Compound ...)
Affinity DataIC50: 0.300nMAssay Description:n general, kinases regulate many important cellular activities including cell growth, signaling, metabolism, etc. Different kinases have distinct fun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM456973(US10738007, Compound ID 39 | US11555039, Compound ...)
Affinity DataIC50: 0.300nMAssay Description:The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM456959(US10738007, Compound ID 23 | US11555039, Compound ...)
Affinity DataIC50: 0.300nMAssay Description:The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

Displayed 1 to 50 (of 8271 total ) | Next | Last >>
Jump to: