Compile Data Set for Download or QSAR
Report error Found 9 of affinity data for UniProtKB/TrEMBL: P04925
TargetMajor prion protein(Mouse)
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 95nMAssay Description:Synergistic anti-prion activity of mouse ScN2a cells infected with RML prion assessed as reduction of RML accumulation by isobologram analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMajor prion protein(Mouse)
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)

Curated by ChEMBL
LigandPNGBDBM50600940(CHEMBL5081846)
Affinity DataIC50: 950nMAssay Description:Synergistic anti-prion activity of mouse ScN2a cells infected with RML prion assessed as reduction of RML accumulation by isobologram analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMajor prion protein(Mouse)
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)

Curated by ChEMBL
LigandPNGBDBM50001888([3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-...)
Affinity DataEC50:  2.00E+3nMAssay Description:Activity at mouse prion protein expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMajor prion protein(Mouse)
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)

Curated by ChEMBL
LigandPNGBDBM50333111(2-(2-(butylamino)-1H-benzo[d]imidazol-1-yl)-1-(ind...)
Affinity DataKd:  2.00E+4nMAssay Description:Binding affinity to mouse recombinant PrP (121-231) after 10 mins by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMajor prion protein(Mouse)
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)

Curated by ChEMBL
LigandPNGBDBM50333115(N-(3-cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thio...)
Affinity DataKd:  2.19E+4nMAssay Description:Binding affinity to mouse recombinant PrP (121-231) after 10 mins by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMajor prion protein(Mouse)
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)

Curated by ChEMBL
LigandPNGBDBM50333114(2-(1H-indol-3-yl)-N-(1,2,3,4-tetrahydronaphthalen-...)
Affinity DataKd:  4.86E+4nMAssay Description:Binding affinity to mouse recombinant PrP (121-231) after 10 mins by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMajor prion protein(Mouse)
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)

Curated by ChEMBL
LigandPNGBDBM50333113(8-methyl-7-(2-(piperidin-1-yl)ethylthio)-2,3-dihyd...)
Affinity DataKd:  5.08E+4nMAssay Description:Binding affinity to mouse recombinant PrP (121-231) after 10 mins by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMajor prion protein(Mouse)
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)

Curated by ChEMBL
LigandPNGBDBM50333110(N-(1-(indolin-1-yl)-3-methyl-1-oxopentan-2-yl)benz...)
Affinity DataKd:  5.12E+4nMAssay Description:Binding affinity to mouse recombinant PrP (121-231) after 10 mins by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMajor prion protein(Mouse)
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)

Curated by ChEMBL
LigandPNGBDBM50333112(3-amino-N-cyclopentyl-8-methylthieno[2,3-b]quinoli...)
Affinity DataKd:  8.61E+4nMAssay Description:Binding affinity to mouse recombinant PrP (121-231) after 10 mins by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed