Compile Data Set for Download or QSAR
Report error Found 3054 for UniProtKB: P31424
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50215552BDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataIC50: 0.00100nMAssay Description:Activity at human recombinant mGluR5 in CHO cells assessed as inhibition of quisqualate-stimulated phosphoinositide hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50105834BDBM50105834(CHEMBL3597594)
Affinity DataKi:  0.0300nMAssay Description:Displacement of [3H]MPEP from mGluR5 receptor in Sprague-Dawley rat forebrain membrane after 60 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50215552BDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataIC50: 0.0360nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50215552BDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi:  0.0360nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50215556BDBM50215556(3-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzoni...)
Affinity DataIC50: 0.0600nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50258612BDBM50258612(3-Fluoro-5-cyano-1-(2-methylthiazol-4-ylethynyl)be...)
Affinity DataKi:  0.0800nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50105833BDBM50105833(CHEMBL3597593)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]MPEP from mGluR5 receptor in Sprague-Dawley rat forebrain membrane after 60 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50345553BDBM50345553(3-(2-(2-methylthiazol-4-yl)ethynyl)-5-bromobenzoni...)
Affinity DataKi:  0.106nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50345552BDBM50345552(3-(2-(2-methylthiazol-4-yl)ethynyl)-5-chlorobenzon...)
Affinity DataKi:  0.127nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50345572BDBM50345572(3-(2-(pyridin-2-yl)ethynyl)-5-fluorobenzonitrile |...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50105801BDBM50105801(CHEMBL3597596)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]MPEP from mGluR5 receptor in Sprague-Dawley rat forebrain membrane after 60 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50084137BDBM50084137(2-Methyl-6-phenylethynyl-pyridine | CHEMBL66654 | ...)
Affinity DataIC50: 0.200nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50215553BDBM50215553(5-(2-(2-fluoromethyl)thiazole-4-yl)ethynyl)pyridin...)
Affinity DataIC50: 0.230nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181745BDBM50181745(3-[(2-methyl-4-thiazolyl)ethynyl]benzonitrile | CH...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50336827BDBM50336827(3-[(2-Aminothiazol)-4-ethynyl]-5-fluorobenzonitril...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50336830BDBM50336830(3-((2-Chlorothiazol)-4-yl)ethynyl)benzonitrile | C...)
Affinity DataKi:  0.270nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50336843BDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi:  0.280nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50084137BDBM50084137(2-Methyl-6-phenylethynyl-pyridine | CHEMBL66654 | ...)
Affinity DataKi:  0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50345555BDBM50345555(3-(2-(2-methylthiazol-4-yl)ethynyl)-5-nitrofluorob...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50345567BDBM50345567(3-(2-(5-methylpyridin-2-yl)ethynyl)-5-fluorobenzon...)
Affinity DataIC50: 0.320nMAssay Description:Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50345550BDBM50345550(3-(2-(2-Methylthiazol-4-yl)ethynyl)-5-nitrobenzoni...)
Affinity DataKi:  0.360nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50258612BDBM50258612(3-Fluoro-5-cyano-1-(2-methylthiazol-4-ylethynyl)be...)
Affinity DataKi:  0.360nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50345570BDBM50345570(3-(2-(pyridin-2-yl)ethynyl)-5-bromonitrobenzene | ...)
Affinity DataIC50: 0.390nMAssay Description:Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50105805BDBM50105805(CHEMBL3597600)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]MPEP from mGluR5 receptor in Sprague-Dawley rat forebrain membrane after 60 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50105803BDBM50105803(CHEMBL3597598)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]MPEP from mGluR5 receptor in Sprague-Dawley rat forebrain membrane after 60 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50105802BDBM50105802(CHEMBL3597597)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]MPEP from mGluR5 receptor in Sprague-Dawley rat forebrain membrane after 60 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50336831BDBM50336831(3-((2-Chlorothiazol)-4-yl)ethynyl)-5-fluorobenzoni...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50160632BDBM50160632(3-(6-Methyl-pyridin-2-ylethynyl)-benzonitrile | 3-...)
Affinity DataIC50: 0.420nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate cha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50215555BDBM50215555(2-(fluoromethyl)-4-(2-(3-fluorophenyl)ethynylthiaz...)
Affinity DataIC50: 0.480nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50215554BDBM50215554(2-(fluoromethyl)4-(2-(3-methoxyphenyl)ethynyl)thia...)
Affinity DataIC50: 0.520nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 109106BDBM109106(US8609852, 13)
Affinity DataKi:  0.600nM ΔG°:  -52.6kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2014
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50105831BDBM50105831(CHEMBL3597584)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]MPEP from mGluR5 receptor in Sprague-Dawley rat forebrain membrane after 60 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318382BDBM50318382(CHEMBL1094807 | CHEMBL1094474 | 3-[pyridine-2-yl)e...)
Affinity DataKd:  0.600nMAssay Description:Binding affinity to mGluR5 ligand binding site 1 in Sprague-Dawley rat brain P2 membrane after 45 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 109106BDBM109106(US8609852, 13)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine from mGlu5R in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50105832BDBM50105832(CHEMBL3597592)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]MPEP from mGluR5 receptor in Sprague-Dawley rat forebrain membrane after 60 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50345555BDBM50345555(3-(2-(2-methylthiazol-4-yl)ethynyl)-5-nitrofluorob...)
Affinity DataIC50: 0.610nMAssay Description:Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50345560BDBM50345560(3-(2-(6-methylpyridin-2-yl)ethynyl)-5-nitrobromobe...)
Affinity DataIC50: 0.630nMAssay Description:Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 109136BDBM109136(US8609852, 43)
Affinity DataKi:  0.650nM ΔG°:  -52.4kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2014
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 109136BDBM109136(US8609852, 43)
Affinity DataKi:  0.650nMAssay Description:Displacement of [3H]methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine from mGlu5R in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50172117BDBM50172117(2-Cyclohex-1-enylethynyl-pyridine | CHEMBL196643)
Affinity DataKi:  0.650nMAssay Description:Displacement of [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from mGlu5 receptor of rat cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50345572BDBM50345572(3-(2-(pyridin-2-yl)ethynyl)-5-fluorobenzonitrile |...)
Affinity DataIC50: 0.660nMAssay Description:Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50345573BDBM50345573(3-(2-(pyridin-2-yl)ethynyl)-5-iodobenzonitrile | C...)
Affinity DataIC50: 0.660nMAssay Description:Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50345574BDBM50345574(3-(2-(pyridin-2-yl)ethynyl)-5-nitrofluorobenzene |...)
Affinity DataIC50: 0.660nMAssay Description:Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50345562BDBM50345562(3-(2-(6-methylpyridin-2-yl)ethynyl)-5-fluorobenzon...)
Affinity DataKi:  0.670nMAssay Description:Displacement of [3H]MPEP from mGluR5 in Sprague-Dawley rat brain membrane after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50345558BDBM50345558(3-(2-(2-methylthiazol-4-yl)ethynyl)-1,5-dibromoben...)
Affinity DataKi:  0.690nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 109101BDBM109101(US8609852, 7)
Affinity DataKi:  0.700nM ΔG°:  -52.3kJ/moleT: 2°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2014
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50345563BDBM50345563(3-(2-(6-methylpyridin-2-yl)ethynyl)-5-iodobenzonit...)
Affinity DataIC50: 0.710nMAssay Description:Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181753BDBM50181753(US8609852, 78 | CHEMBL202307 | 3-[(2-methyl-4-thia...)
Affinity DataKi:  0.710nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50220087BDBM50220087(2-(3,5-dichlorophenyl)-7-methylpyrido[2,3-d]pyrimi...)
Affinity DataIC50: 0.720nMAssay Description:Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50345551BDBM50345551(3-(2-(2-methylthiazol-4-yl)ethynyl)-5-nitrobromobe...)
Affinity DataIC50: 0.730nMAssay Description:Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
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