Compile Data Set for Download or QSAR
Report error Found 2436 of affinity data for UniProtKB/TrEMBL: P34998
TargetCorticotropin-releasing factor receptor 1(Human)
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WIPO
LigandPNGBDBM581978(WO2023285347, Compound 1 | DNPSLSIDLTFHLLRTLLELART...)
Affinity DataIC50: 0.0700nMAssay Description:Receptor SPA binding assays were performed in white 96-well plates in a total volume of 200 mI per well. Freeze dried analogues were dissolved in 80%...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2023
Entry Details
WIPO WO2023285347

TargetCorticotropin-releasing factor receptor 1(Human)
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WIPO
LigandPNGBDBM50153477(CHEMBL3775524)
Affinity DataKi:  0.160nMAssay Description:Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
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WIPO
LigandPNGBDBM50153473(CHEMBL3775796)
Affinity DataKi:  0.180nMAssay Description:Displacement of [125ITyr0-Glu1]-PD-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
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WIPO
LigandPNGBDBM50153499(CHEMBL3774658)
Affinity DataKi:  0.200nMAssay Description:Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
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WIPO
LigandPNGBDBM50272695(3-(4-chloro-2-morpholinothiazol-5-yl)-2,6-dimethyl...)
Affinity DataKi:  0.200nMAssay Description:Antagonist activity at human CRF-1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
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WIPO
LigandPNGBDBM50272695(3-(4-chloro-2-morpholinothiazol-5-yl)-2,6-dimethyl...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
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WIPO
LigandPNGBDBM50153579(CHEMBL3774395)
Affinity DataKi:  0.200nMAssay Description:Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
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WIPO
LigandPNGBDBM50087703(Urocortin-human(DNPSLSIDLTFHLLRTLLELARTQSQRERAEQNR...)
Affinity DataEC50:  0.220nMAssay Description:Activity of peptidic agonists on corticotropin releasing factor receptor using agonist-stimulated adenylate cyclase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
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WIPO
LigandPNGBDBM50153481(CHEMBL3774868)
Affinity DataKi:  0.220nMAssay Description:Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
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WIPO
LigandPNGBDBM50026981(CHEMBL2370939)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of recombinant corticotropin releasing factor receptor 1 assayed using nonselective [125I]-labeled agonist [Tyr0,Glu1,Nle17]-sauvagineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50153497(CHEMBL3775030)
Affinity DataKi:  0.240nMAssay Description:Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50153498(CHEMBL3774682)
Affinity DataKi:  0.25nMAssay Description:Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50087713(CHEMBL45187 | DMP904 | DMP-904 | (1-Ethyl-propyl)-...)
Affinity DataKd:  0.279nMAssay Description:Binding affinity to recombinant human CRF1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50153579(CHEMBL3774395)
Affinity DataKi:  0.280nMAssay Description:Displacement of [125ITyr0-Glu1]-PD-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50153482(CHEMBL3775357)
Affinity DataKi:  0.290nMAssay Description:Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50354983(CHEMBL1836947)
Affinity DataKd:  0.291nMAssay Description:Binding affinity to recombinant human CRF1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50354983(CHEMBL1836947)
Affinity DataKi:  0.291nMAssay Description:Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50362270(CHEMBL1939594)
Affinity DataEC50:  0.300nMAssay Description:Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50153482(CHEMBL3775357)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50116105(3-(6-(dimethylamino)-4-methylpyridin-3-yl)-2,5-dim...)
Affinity DataKd:  0.303nMAssay Description:Binding affinity to recombinant human CRF1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50153473(CHEMBL3775796)
Affinity DataKi:  0.310nMAssay Description:Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50153494(CHEMBL3775621)
Affinity DataKi:  0.340nMAssay Description:Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50153480(CHEMBL3775195)
Affinity DataKi:  0.350nMAssay Description:Displacement of [125ITyr0-Glu1]-PD-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50354981(CHEMBL1836945)
Affinity DataKd:  0.373nMAssay Description:Binding affinity to recombinant human CRF1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50354981(CHEMBL1836945)
Affinity DataKi:  0.373nMAssay Description:Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50084878(Butyl-[8-(2,4-dichloro-phenyl)-2,7-dimethyl-pyrazo...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I]-tyrosine-ovine-CRF from human Corticotropin releasing factor receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50058163(CHEMBL9946 | CP 154,526 | CP-154526 | N-butyl-N-et...)
Affinity DataKi:  0.400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50087713(CHEMBL45187 | DMP904 | DMP-904 | (1-Ethyl-propyl)-...)
Affinity DataKi:  0.400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50153484(CHEMBL3775678)
Affinity DataKi:  0.420nMAssay Description:Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50153574(CHEMBL3775778)
Affinity DataKi:  0.430nMAssay Description:Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50153491(CHEMBL3775596)
Affinity DataKi:  0.450nMAssay Description:Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50153488(CHEMBL3775288)
Affinity DataKi:  0.460nMAssay Description:Displacement of [125ITyr0-Glu1]-PD-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50153477(CHEMBL3775524)
Affinity DataKi:  0.480nMAssay Description:Displacement of [125ITyr0-Glu1]-PD-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50153486(CHEMBL3775437)
Affinity DataKi:  0.490nMAssay Description:Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50153496(CHEMBL3775812)
Affinity DataKi:  0.490nMAssay Description:Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50132965(Cyclopropylmethyl-[8-(2,4-dichloro-phenyl)-2-methy...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity towards cloned human Corticotropin releasing factor receptor 1 expressed in CHO cells using [125I]o-CRF as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50153495(CHEMBL3774594)
Affinity DataKi:  0.5nMAssay Description:Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50153580(CHEMBL3775761)
Affinity DataKi:  0.520nMAssay Description:Displacement of [125ITyr0-Glu1]-PD-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50153480(CHEMBL3775195)
Affinity DataKi:  0.530nMAssay Description:Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50153578(CHEMBL3775192)
Affinity DataKi:  0.590nMAssay Description:Displacement of [125ITyr0-Glu1]-PD-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50362277(CHEMBL1939601)
Affinity DataEC50:  0.600nMAssay Description:Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50084876([8-(2,4-Dichloro-phenyl)-2,7-dimethyl-pyrazolo[1,5...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [125I]-tyrosine-ovine-CRF from human Corticotropin releasing factor receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50153485(CHEMBL3774939)
Affinity DataKi:  0.610nMAssay Description:Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50132898(Dibutyl-[3-(2,4-dichloro-phenyl)-1,5-dimethyl-1H-p...)
Affinity DataKi:  0.620nMAssay Description:Inhibition of (Corticotropin-Releasing Factor Receptor) CRF-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50132898(Dibutyl-[3-(2,4-dichloro-phenyl)-1,5-dimethyl-1H-p...)
Affinity DataKi:  0.620nMAssay Description:Compound was tested to inhibit Corticotropin releasing factor receptor 1-stimulated c-AMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50153580(CHEMBL3775761)
Affinity DataKi:  0.640nMAssay Description:Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50153490(CHEMBL3774836)
Affinity DataKi:  0.680nMAssay Description:Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50153578(CHEMBL3775192)
Affinity DataKi:  0.680nMAssay Description:Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50153500(CHEMBL3774485)
Affinity DataKi:  0.690nMAssay Description:Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Novo Nordisk

WIPO
LigandPNGBDBM50153576(CHEMBL3774742)
Affinity DataKi:  0.690nMAssay Description:Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
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