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TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50536711(CHEMBL4550190)
Affinity DataEC50:  0.200nMAssay Description:Positive allosteric modulation of human mGluR5A transfected in HEK293 cells assessed as potentiation of L-glutamate-induced calcium release incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50105802(CHEMBL3597597)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]MPEP from human cloned mGluR5 receptor expressed in CHO-T-Rex cells after 60 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50105801(CHEMBL3597596)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]MPEP from human cloned mGluR5 receptor expressed in CHO-T-Rex cells after 60 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50105833(CHEMBL3597593)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]MPEP from human cloned mGluR5 receptor expressed in CHO-T-Rex cells after 60 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50105805(CHEMBL3597600)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]MPEP from human cloned mGluR5 receptor expressed in CHO-T-Rex cells after 60 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM141505(US8921370, 126 | US9656975, 126)
Affinity DataIC50: 0.320nMpH: 7.4 T: 2°CAssay Description:The cDNA for rat metabotropic glutamate receptor 5 (rmGluR5) and the cDNA for human metabotropic glutamate receptor 5 (rmGluR5) were generous gifts f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2015
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50181745(3-[(2-methyl-4-thiazolyl)ethynyl]benzonitrile | CH...)
Affinity DataKi:  0.370nMAssay Description:Displacement of [3H]MPEP from cloned human mGluR5 transfected in HEK293-T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50411769(CHEMBL403390)
Affinity DataIC50: 0.398nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50411838(CHEMBL271276)
Affinity DataIC50: 0.398nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50113479(CHEMBL3603926 | US10246432, Example 22 | US1058411...)
Affinity DataIC50: 0.398nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50105833(CHEMBL3597593)
Affinity DataIC50: 0.400nMAssay Description:Negative allosteric modulatory activity at human cloned mGluR5 receptor expressed in CHO-T-Rex cells assessed as inhibiton of quisqualate-induced cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50105837(CHEMBL3597585)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]MPEP from human cloned mGluR5 receptor expressed in CHO-T-Rex cells after 60 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50105832(CHEMBL3597592)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]MPEP from human cloned mGluR5 receptor expressed in CHO-T-Rex cells after 60 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50536710(CHEMBL4560002)
Affinity DataEC50:  0.400nMAssay Description:Positive allosteric modulation of human mGluR5A transfected in HEK293 cells assessed as potentiation of L-glutamate-induced calcium release incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50105803(CHEMBL3597598)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]MPEP from human cloned mGluR5 receptor expressed in CHO-T-Rex cells after 60 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50105806(CHEMBL3597602)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]MPEP from human cloned mGluR5 receptor expressed in CHO-T-Rex cells after 60 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50105834(CHEMBL3597594)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]MPEP from human cloned mGluR5 receptor expressed in CHO-T-Rex cells after 60 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50149801(5-(2-Methyl-thiazol-4-ylethynyl)-2-phenyl-pyridine...)
Affinity DataIC50: 0.5nMAssay Description:In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50105834(CHEMBL3597594)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]MPEP from human mGlu5 receptor expressed in CHO-TREx cell membranes after 60 mins by liquid scintillation spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50105834(CHEMBL3597594)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]MPEP from human mGlu5 receptor expressed in CHO-TREx cell membranes after 60 mins by liquid scintillation spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50105831(CHEMBL3597584)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]MPEP from human cloned mGluR5 receptor expressed in CHO-T-Rex cells after 60 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50113468(CHEMBL3603915 | US10246432, Example 15 | US1058411...)
Affinity DataKi:  0.501nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50113468(CHEMBL3603915 | US10246432, Example 15 | US1058411...)
Affinity DataKi:  0.501nMAssay Description:Membrane PreparationcDNA encoding the human mGlu5 receptor was transfected into HEK293 cells using the transfection reagent Genejuice (Novagen). Fort...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50113468(CHEMBL3603915 | US10246432, Example 15 | US1058411...)
Affinity DataKi:  0.501nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50113468(CHEMBL3603915 | US10246432, Example 15 | US1058411...)
Affinity DataKi:  0.501nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50113476(CHEMBL3603923 | US10246432, Example 17 | US1058411...)
Affinity DataKi:  0.501nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50113476(CHEMBL3603923 | US10246432, Example 17 | US1058411...)
Affinity DataIC50: 0.501nMAssay Description:Inhibition of mGLU5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50113476(CHEMBL3603923 | US10246432, Example 17 | US1058411...)
Affinity DataKi:  0.537nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50113476(CHEMBL3603923 | US10246432, Example 17 | US1058411...)
Affinity DataKi:  0.537nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50113476(CHEMBL3603923 | US10246432, Example 17 | US1058411...)
Affinity DataKi:  0.537nMAssay Description:Membrane PreparationcDNA encoding the human mGlu5 receptor was transfected into HEK293 cells using the transfection reagent Genejuice (Novagen). Fort...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50536713(CHEMBL4588437)
Affinity DataEC50:  0.600nMAssay Description:Positive allosteric modulation of human mGluR5A transfected in HEK293 cells assessed as potentiation of L-glutamate-induced calcium release incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50536712(CHEMBL4571075)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]-MPEPy from human mGluR5A transfected in HEK293 cell membranes after 60 mins by microbeta liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50113477(CHEMBL3603924 | US10246432, Example 3 | US10584111...)
Affinity DataKi:  0.631nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50113476(CHEMBL3603923 | US10246432, Example 17 | US1058411...)
Affinity DataIC50: 0.631nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50113477(CHEMBL3603924 | US10246432, Example 3 | US10584111...)
Affinity DataIC50: 0.631nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM571410(ethyl (4E)-4-[3-(3- cyanophenyl)prop-2-yn-1- ylide...)
Affinity DataKi:  0.640nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM594149(6-[6-(3-chloro-5- | US11584732, Example 3)
Affinity DataKi:  0.692nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50113477(CHEMBL3603924 | US10246432, Example 3 | US10584111...)
Affinity DataKi:  0.692nMAssay Description:Membrane PreparationcDNA encoding the human mGlu5 receptor was transfected into HEK293 cells using the transfection reagent Genejuice (Novagen). Fort...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50113477(CHEMBL3603924 | US10246432, Example 3 | US10584111...)
Affinity DataKi:  0.692nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50529980(CHEMBL4535926)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]MPEP from human mGlu5 receptor expressed in CHO-TREx cell membranes after 60 mins by liquid scintillation spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50529958(CHEMBL4472693)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]MPEP from human mGlu5 receptor expressed in CHO-TREx cell membranes after 60 mins by liquid scintillation spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50529980(CHEMBL4535926)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]MPEP from human mGlu5 receptor expressed in CHO-TREx cell membranes after 60 mins by liquid scintillation spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50529958(CHEMBL4472693)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]MPEP from human mGlu5 receptor expressed in CHO-TREx cell membranes after 60 mins by liquid scintillation spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50536704(CHEMBL4580610)
Affinity DataEC50:  0.700nMAssay Description:Positive allosteric modulation of human mGluR5A transfected in HEK293 cells assessed as potentiation of L-glutamate-induced calcium release incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50143544(CHEMBL3759766)
Affinity DataIC50: 0.790nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced effect by aequorin bioluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50411851(CHEMBL257880)
Affinity DataIC50: 0.794nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50113479(CHEMBL3603926 | US10246432, Example 22 | US1058411...)
Affinity DataKi:  0.794nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50169541(CHEMBL3805542)
Affinity DataEC50:  0.800nMAssay Description:Positive allosteric modulation of human mGluR5A transfected in HEK293 cells assessed as potentiation of L-glutamate-induced calcium release incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50105834(CHEMBL3597594)
Affinity DataIC50: 0.800nMAssay Description:Negative allosteric modulatory activity at human cloned mGluR5 receptor expressed in CHO-T-Rex cells assessed as inhibiton of quisqualate-induced cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50105834(CHEMBL3597594)
Affinity DataIC50: 0.800nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
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