Compile Data Set for Download or QSAR
Report error Found 659 of affinity data for UniProtKB/TrEMBL: P43119
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM357269(US10214518, Compound 90 | 2-(((1s,4s)-4-((5- (ethy...)
Affinity DataEC50:  7nMAssay Description:The HTRF assay was carried out using a two-step protocol essentially according to the kit manufacturer's instructions, in 20 μL total volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM357270(US10214518, Compound 111 | 2-(((1s,4s)-4-((5- (met...)
Affinity DataEC50:  16nMAssay Description:The HTRF assay was carried out using a two-step protocol essentially according to the kit manufacturer's instructions, in 20 μL total volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM357271(US10214518, Compound 184 | 2-(((1s,4s)-4-((5- (cya...)
Affinity DataEC50:  11nMAssay Description:The HTRF assay was carried out using a two-step protocol essentially according to the kit manufacturer's instructions, in 20 μL total volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM357272(US10214518, Compound 198 | 2-(((1s,4s)-4-((5-(2- h...)
Affinity DataEC50:  2nMAssay Description:The HTRF assay was carried out using a two-step protocol essentially according to the kit manufacturer's instructions, in 20 μL total volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM62356(US9422273, 12b)
Affinity DataEC50:  860nMpH: 7.4 T: 2°CAssay Description:Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2017
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM240744(US9422273, 12a)
Affinity DataEC50:  550nMpH: 7.4 T: 2°CAssay Description:Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2017
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM240745(US9422273, 12c)
Affinity DataEC50:  9.50E+3nMpH: 7.4 T: 2°CAssay Description:Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2017
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM240746(US9422273, 12d)
Affinity DataEC50:  1.00E+3nMpH: 7.4 T: 2°CAssay Description:Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2017
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM240747(US9422273, 12e)
Affinity DataEC50:  290nMpH: 7.4 T: 2°CAssay Description:Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2017
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM444830(2-(((1r,4r)-4-((3-(3- chlorophenyl)-3- phenylureid...)
Affinity DataEC50:  61.1nMAssay Description:Compounds were screened for agonists of the human prostacyclin (PGI2) receptor using the HTRF assay for direct cAMP measurement (Gabriel et al., ASSA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM444831(2-(((1s,4s)-4-(((4- fluorophenyl)(phenyl) carbamoy...)
Affinity DataEC50:  56.9nMAssay Description:Compounds were screened for agonists of the human prostacyclin (PGI2) receptor using the HTRF assay for direct cAMP measurement (Gabriel et al., ASSA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50235379(CHEMBL3932106 | US10668033, Compound 55)
Affinity DataEC50:  5.14nMAssay Description:Compounds were screened for agonists of the human prostacyclin (PGI2) receptor using the HTRF assay for direct cAMP measurement (Gabriel et al., ASSA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM444835(2-(((1r,4r)-4-(((3- fluorophenyl)(5-methylthiophen...)
Affinity DataEC50:  19.1nMAssay Description:Compounds were screened for agonists of the human prostacyclin (PGI2) receptor using the HTRF assay for direct cAMP measurement (Gabriel et al., ASSA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM464509(US10793529, Compound 69 | 2-(((1s,4s)-4-((6-(4- me...)
Affinity DataEC50:  8nMAssay Description:The HTRF assay was carried out using a two-step protocol essentially according to the kit manufacturer's instructions, in 20 μL total volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM464510(US10793529, Compound 31 | 2-(((1s,4s,)-4-((4-(3-ch...)
Affinity DataEC50:  31nMAssay Description:The HTRF assay was carried out using a two-step protocol essentially according to the kit manufacturer's instructions, in 20 μL total volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM464511(US10793529, Compound 43 | 2-(((1s,4s)-4-((3-oxo-5,...)
Affinity DataEC50:  36nMAssay Description:The HTRF assay was carried out using a two-step protocol essentially according to the kit manufacturer's instructions, in 20 μL total volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM464512(US10793529, Compound 67 | 2-(((1s,4s)-4-((5-(3- ch...)
Affinity DataEC50:  73nMAssay Description:The HTRF assay was carried out using a two-step protocol essentially according to the kit manufacturer's instructions, in 20 μL total volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM357269(US10214518, Compound 90 | 2-(((1s,4s)-4-((5- (ethy...)
Affinity DataEC50:  7nMAssay Description:Principle of the assay: The HTRF assay kit was purchased from Cisbio-US, Inc. (Bedford, Mass.; Catalog #62AM4PEC). The HTRF assay supported by the ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM357270(US10214518, Compound 111 | 2-(((1s,4s)-4-((5- (met...)
Affinity DataEC50:  16nMAssay Description:Principle of the assay: The HTRF assay kit was purchased from Cisbio-US, Inc. (Bedford, Mass.; Catalog #62AM4PEC). The HTRF assay supported by the ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM357271(US10214518, Compound 184 | 2-(((1s,4s)-4-((5- (cya...)
Affinity DataEC50:  11nMAssay Description:Principle of the assay: The HTRF assay kit was purchased from Cisbio-US, Inc. (Bedford, Mass.; Catalog #62AM4PEC). The HTRF assay supported by the ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM357272(US10214518, Compound 198 | 2-(((1s,4s)-4-((5-(2- h...)
Affinity DataEC50:  2nMAssay Description:Principle of the assay: The HTRF assay kit was purchased from Cisbio-US, Inc. (Bedford, Mass.; Catalog #62AM4PEC). The HTRF assay supported by the ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50101823(4-(2-{(1R,3R)-3-Hydroxy-2-[(E)-(S)-4-hydroxy-4-(1-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50101853((13E,15S)-11alpha,15-dihydroxy-9-oxoprost-13-en-1-...)
Affinity DataEC50:  1.80nMAssay Description:Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50101832((E)-7-{(1R,3R)-3-Hydroxy-2-[(E)-(S)-4-hydroxy-4-(1...)
Affinity DataEC50: >1.00E+4nMAssay Description:Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50101824(Butaprost (Methyl Ester) | BUTAPROST | CHEMBL43252...)
Affinity DataEC50:  37nMAssay Description:Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50101829(7-{(1R,3R)-3-Hydroxy-2-[(E)-(S)-4-hydroxy-4-(1-pro...)
Affinity DataEC50:  25nMAssay Description:Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50101822(CHEMBL64804 | PGE2, 15-epi | (Z)-7-[(1R,2R,3R)-3-H...)
Affinity DataEC50:  260nMAssay Description:Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50594971(TREPROSTINIL | CHEBI:50861 | Treprostinil | Trespr...)
Affinity DataEC50:  1.90nMAssay Description:Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50103390(CHEMBL3398234)
Affinity DataEC50:  85nMAssay Description:Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50103391(CHEMBL3398233)
Affinity DataEC50:  4nMAssay Description:Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50103392(CHEMBL3398232)
Affinity DataEC50:  20nMAssay Description:Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50103393(CHEMBL3398231)
Affinity DataEC50:  260nMAssay Description:Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50103397(CHEMBL3398237)
Affinity DataEC50:  79nMAssay Description:Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50103396(CHEMBL3398236)
Affinity DataEC50:  6nMAssay Description:Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50103395(CHEMBL3398235)
Affinity DataEC50:  33nMAssay Description:Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50103416(CHEMBL3398230)
Affinity DataEC50:  140nMAssay Description:Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50103394(CHEMBL3398229)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50103404(CHEMBL3398228)
Affinity DataEC50:  38nMAssay Description:Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50103413(CHEMBL3398227)
Affinity DataEC50:  120nMAssay Description:Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50103418(CHEMBL3398226)
Affinity DataEC50:  1.06E+3nMAssay Description:Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50103422(CHEMBL3398225)
Affinity DataEC50:  86nMAssay Description:Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50103412(CHEMBL3398224)
Affinity DataEC50:  60nMAssay Description:Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50103411(CHEMBL3398223)
Affinity DataEC50:  140nMAssay Description:Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50103410(CHEMBL3398222)
Affinity DataEC50:  100nMAssay Description:Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50103409(CHEMBL3398221)
Affinity DataEC50:  62nMAssay Description:Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50103408(CHEMBL3398220)
Affinity DataEC50:  9.5nMAssay Description:Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50103407(CHEMBL3398219)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50103406(CHEMBL3398218)
Affinity DataEC50:  20nMAssay Description:Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM50103423(CHEMBL3398217)
Affinity DataEC50:  114nMAssay Description:Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
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