Compile Data Set for Download or QSAR
Report error Found 2229 of affinity data for UniProtKB/TrEMBL: Q05941
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50143314BDBM50143314(CHEMBL298826 | (+)-Epibatidine | 2-(6-Chloro-pyrid...)
Affinity DataKi:  0.00600nMAssay Description:Inhibition of [125I]-iodo-MLA binding to Nicotinic acetylcholine receptor alpha-7 of rat cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50364856BDBM50364856(CHEMBL1950167)
Affinity DataKi:  0.0230nMAssay Description:Displacement of [3H]methyllylcaconitine from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50319933BDBM50319933((1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-...)
Affinity DataKi:  0.0660nMAssay Description:Displacement of [3H]A585539 from alpha7 nACHR in rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50364875BDBM50364875(CHEMBL1950156)
Affinity DataKi:  0.0920nMAssay Description:Displacement of [3H]methyllylcaconitine from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 165927BDBM165927(US9067931, 75 | US10214524, Example 75)
Affinity DataKi: <0.100nMAssay Description:Rat brain tissue (hippocampus or whole brain) is homogenized in homogenization buffer (10% w/v, 0.32 M sucrose, 1 mM EDTA, 0.1 mM phenylmethylsulphon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 165927BDBM165927(US9067931, 75 | US10214524, Example 75)
Affinity DataKi: <0.100nM ΔG°: <-53.1kJ/molepH: 7.4 T: 2°CAssay Description:The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol. 1999, 38, 679-690.Rat brain t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50164899BDBM50164899(5-Iodo-thiophene-2-carboxylic acid ((2R,3R)-2-pyri...)
Affinity DataKi:  0.120nMAssay Description:Inhibitory constant against [3H]methyllycaconitine binding towards Nicotinic acetylcholine receptor alpha-7 of rat brain hippocampusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50006617BDBM50006617(CHEMBL3235490)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]MLA from rat alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50513620BDBM50513620(CHEMBL4563574)
Affinity DataKi:  0.200nMAssay Description:Displacement of [125I]-alpha-bungarotoxin from alpha7 nAChR in Wistar rat brain membrane incubated for 3 hrs by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50393252BDBM50393252(CHEMBL2151570)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]A-585539 from alpha7 nAChR rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50319964BDBM50319964(5-(6-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]A585539 from alpha7 nACHR in rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50279059BDBM50279059(cis-5-[6-(5-Methyl-hexahydro-pyrrolo[3,4-c]pyrrol-...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]A585539 from alpha7 nicotinic acetylcholine receptor in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50006623BDBM50006623(CHEMBL3235501)
Affinity DataKi:  0.260nMAssay Description:Displacement of [125I]-alpha-BTX from rat alpha7-nAChR after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50364879BDBM50364879(CHEMBL1950160)
Affinity DataKi:  0.280nMAssay Description:Displacement of [3H]methyllylcaconitine from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50513605BDBM50513605(CHEMBL4563839)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I]-alpha-bungarotoxin from alpha7 nAChR in Wistar rat brain membrane incubated for 3 hrs by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50319944BDBM50319944(2-methyl-5-(6-((1S,4S)-5-methyl-2,5-diazabicyclo[2...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]A585539 from alpha7 nACHR in rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50357061BDBM50357061(CHEMBL1917228)
Affinity DataKd:  0.300nMAssay Description:Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR in Sprague-Dawley rat cerebral cortex by beta countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50513617BDBM50513617(CHEMBL4459802)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I]-alpha-bungarotoxin from alpha7 nAChR in Wistar rat brain membrane incubated for 3 hrs by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50513583BDBM50513583(CHEMBL4533685)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I]-alpha-bungarotoxin from alpha7 nAChR in Wistar rat brain membrane incubated for 3 hrs by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50319963BDBM50319963(5-(6-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]A585539 from alpha7 nACHR in rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50364856BDBM50364856(CHEMBL1950167)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I]alpha-bungarotoxin from rat cortical membrane alpha7-nAChR after 150 mins by gamma-counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50513594BDBM50513594(CHEMBL4556722)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I]-alpha-bungarotoxin from alpha7 nAChR in Wistar rat brain membrane incubated for 3 hrs by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50364874BDBM50364874(CHEMBL1950155)
Affinity DataKi:  0.310nMAssay Description:Displacement of [3H]methyllylcaconitine from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50006619BDBM50006619(CHEMBL3235485)
Affinity DataKi:  0.340nMAssay Description:Displacement of [125I]alpha-bungarotoxin from rat cortical membrane alpha7-nAChR after 150 mins by gamma-counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50006613BDBM50006613(CHEMBL3235480)
Affinity DataKi:  0.370nMAssay Description:Displacement of [125I]alpha-bungarotoxin from rat cortical membrane alpha7-nAChR after 150 mins by gamma-counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 125050BDBM125050(US8772511, 11 | US9714242, 11)
Affinity DataKi:  0.400nMpH: 7.4Assay Description:The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol, 1999, 38, 679-690.Rat brain t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50319940BDBM50319940(5-(6-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]A585539 from alpha7 nACHR in rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50164907BDBM50164907(5-Bromo-thiophene-3-carboxylic acid ((2R,3R)-2-pyr...)
Affinity DataKi:  0.400nMAssay Description:Inhibitory constant against [3H]methyllycaconitine binding towards Nicotinic acetylcholine receptor alpha-7 of rat brain hippocampusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 125050BDBM125050(US8772511, 11 | US9714242, 11)
Affinity DataKi:  0.400nM ΔG°:  -49.9kJ/molepH: 7.4 T: 2°CAssay Description:Rat brain tissue (hippocampus or whole brain) is homogenized in aqueous homogenization buffer (10% w/v, 0.32 M sucrose, 1 mM EDTA, 0.1 mM phenylmethy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2014
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50393247BDBM50393247(CHEMBL1258006)
Affinity DataKi:  0.420nMAssay Description:Displacement of [3H]methyllycaconitine form alpha7 nAchR in rat hippocampal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50232594BDBM50232594(CHEMBL4102566)
Affinity DataEC50:  0.490nMAssay Description:Agonist activity at rat alpha7 nAChR expressed in HEK293 cells co-expressing human RIC3 assessed as area under current curve at holding potential of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50385393BDBM50385393(CHEMBL2036415)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]A585539 from alpha7 nAChR from rat brain membrane with no cerebellum/cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50364869BDBM50364869(CHEMBL1950150)
Affinity DataKi:  0.580nMAssay Description:Displacement of [3H]methyllylcaconitine from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50385392BDBM50385392(CHEMBL2036416)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]A585539 from alpha7 nAChR from rat brain membrane with no cerebellum/cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50513613BDBM50513613(CHEMBL4567300)
Affinity DataKi:  0.600nMAssay Description:Displacement of [125I]-alpha-bungarotoxin from alpha7 nAChR in Wistar rat brain membrane incubated for 3 hrs by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50164951BDBM50164951((E)-3-Phenyl-N-((2R,3R)-2-pyridin-3-ylmethyl-1-aza...)
Affinity DataKi:  0.600nMAssay Description:Inhibitory constant against [3H]methyllycaconitine binding towards Nicotinic acetylcholine receptor alpha-7 of rat brain hippocampusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50366779BDBM50366779(METHYLLYCACONITINE)
Affinity DataKi:  0.600nMAssay Description:Binding affinity against alpha7 nAChR (nicotinic acetylcholine receptor) using [3H]-MLA as a radioligand relative to alpha4-beta2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50364889BDBM50364889(CHEMBL1950172)
Affinity DataKi:  0.650nMAssay Description:Displacement of [3H]methyllylcaconitine from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50513577BDBM50513577(CHEMBL4445961)
Affinity DataKi:  0.700nMAssay Description:Displacement of [125I]-alpha-bungarotoxin from alpha7 nAChR in Wistar rat brain membrane incubated for 3 hrs by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50164953BDBM50164953(5-Pyridin-2-yl-thiophene-2-carboxylic acid ((2R,3R...)
Affinity DataKi:  0.700nMAssay Description:Inhibitory constant against [3H]methyllycaconitine binding towards Nicotinic acetylcholine receptor alpha-7 of rat brain hippocampusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50366779BDBM50366779(METHYLLYCACONITINE)
Affinity DataKi:  0.800nMAssay Description:Binding affinity against alpha-7 nAChR (nicotinic acetylcholine receptor) using [125I]-alpha-BGT as a radioligand relative to alpha4-beta2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50513611BDBM50513611(CHEMBL4452867)
Affinity DataKi:  0.800nMAssay Description:Displacement of [125I]-alpha-bungarotoxin from alpha7 nAChR in Wistar rat brain membrane incubated for 3 hrs by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50198443BDBM50198443([(2R,3R,4S,5R,6S,8R,9R,13S,16S,18S)-11-ethyl-8,9-d...)
Affinity DataKi:  0.870nMAssay Description:Displacement of [125I]iodoMLA from alpha-7 nAChR in rat cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50513606BDBM50513606(CHEMBL4547917)
Affinity DataKi:  0.900nMAssay Description:Displacement of [125I]-alpha-bungarotoxin from alpha7 nAChR in Wistar rat brain membrane incubated for 3 hrs by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50319939BDBM50319939(5-(6-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]A585539 from alpha7 nACHR in rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50143282BDBM50143282((1R,9R)-7,11-diazatricyclo[7.3.1.0~2,7~]trideca-2,...)
Affinity DataKi:  0.900nMAssay Description:In vitro binding affinity towards Nicotinic acetylcholine receptor alpha7 using [125I]-alpha-Bungarotoxin in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50006621BDBM50006621(CHEMBL3235487)
Affinity DataKi:  0.930nMAssay Description:Displacement of [125I]alpha-bungarotoxin from rat cortical membrane alpha7-nAChR after 150 mins by gamma-counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50110260BDBM50110260(2-Pyridin-3-yl-9-aza-bicyclo[4.2.1]non-2-ene | 2-P...)
Affinity DataKi:  0.950nMAssay Description:Binding affinity to subtype Nicotinic acetylcholine receptor alpha7 using [3H]-MLA as radioligand in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50472784BDBM50472784(METHYLLYCACONITINE[3H] MLA | [3H]-MLA)
Affinity DataKi:  0.980nMAssay Description:Inhibition of [3H]MLA binding in presence of methylcaconitine.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 165926BDBM165926(US9067931, 73 | US10214524, Example 73)
Affinity DataKi: <1nMAssay Description:Rat brain tissue (hippocampus or whole brain) is homogenized in homogenization buffer (10% w/v, 0.32 M sucrose, 1 mM EDTA, 0.1 mM phenylmethylsulphon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

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