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TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451503(CHEMBL12513)
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2A heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50062599(CHEMBL807 | Namenda | 3,5-Dimethyl-adamantan-1-yla...)
Affinity DataIC50: 0.950nMAssay Description:Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/gluta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50038046(2-((S)-9-Bromo-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-...)
Affinity DataKi:  0.960nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451505(CHEMBL274422)
Affinity DataIC50: 1.10nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2A heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50591723(CHEMBL5185347)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50038055(((S)-9-Bromo-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-py...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50591726(CHEMBL450325)
Affinity DataIC50: 2.60nMAssay Description:Displacement of [3H]L-689560 from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50038047(2-(9-Bromo-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-pyri...)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50591722(CHEMBL5208012)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50284815(2-((S)-9-Chloro-6-methyl-2,3-dioxo-2,3,6,7-tetrahy...)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50591721(CHEMBL5208606)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451498(CHEMBL536107)
Affinity DataIC50: 4.20nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2A heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50492253(CHEMBL2398522)
Affinity DataIC50: 4.20nMAssay Description:Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/gluta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50284813(((S)-9-Chloro-6-methyl-2,3-dioxo-2,3,6,7-tetrahydr...)
Affinity DataKi:  4.40nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50591725(CHEMBL61720)
Affinity DataIC50: 4.40nMAssay Description:Displacement of [3H]L-689560 from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50059777((2R,6S)-3-((R)-2-Methoxy-propyl)-6,11,11-trimethyl...)
Affinity DataKi:  4.5nMAssay Description:Antagonist activity at NMDA receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50284817((9-Chloro-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-pyrid...)
Affinity DataKi:  5.10nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50284818(2-(9-Chloro-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-pyr...)
Affinity DataKi:  6.60nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50591724(CHEMBL129149)
Affinity DataKi:  9.60nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50038043((9-Bromo-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-pyrido...)
Affinity DataKi:  9.90nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50069483(N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrahydro-quinoxalin...)
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]MDL from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50069459(Thiophene-3-carboxylic acid (7-bromo-2,3-dioxo-1,2...)
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]MDL from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50069465(Thiophene-2-carboxylic acid (7-bromo-2,3-dioxo-1,2...)
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]MDL from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50599749(CHEMBL5171984)
Affinity DataEC50:  11nMAssay Description:Positive allosteric modulator activity at GluN2A receptor (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50492252(CHEMBL55568)
Affinity DataIC50: 11nMAssay Description:Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/gluta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM521725(US11149056, Compound U6472)
Affinity DataEC50:  13nMAssay Description:Cells are transferred as suspension in serum-free medium to the QPatch HTX system and kept in the cell storage tank/stirrer during experiments. All s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM393276(US9963434, Table 12.219 | 5-(3,4- difluorobenzenes...)
Affinity DataIC50: 16.2nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2A (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451509(CHEMBL268920)
Affinity DataIC50: 18nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2A heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50164477(CHEMBL3800556)
Affinity DataEC50:  18nMAssay Description:Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50130937(Dexoxadrol | Dioxadrol)
Affinity DataKi:  19nMAssay Description:Binding affinity to NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2016
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM393246(US9963434, Table 12.189 | 5-(3-chloro-4- fluoroben...)
Affinity DataIC50: 19.6nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2A (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50205850(CHEMBL3970291 | US10280165, Example 45)
Affinity DataEC50:  21nMAssay Description:Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) expressed in CHO cells assessed as increase in glutamate-induced calcium flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2018
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50164398(CHEMBL3799213)
Affinity DataEC50:  21nMAssay Description:Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50205850(CHEMBL3970291 | US10280165, Example 45)
Affinity DataEC50:  21nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2020
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50130938(Etoxadrol)
Affinity DataKi:  22nMAssay Description:Binding affinity to NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2016
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50164485(CHEMBL3799657)
Affinity DataEC50:  24nMAssay Description:Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM383941((1R,2R)-2-[2-[[5-chloro-3- (trifluoromethyl)pyrazo...)
Affinity DataEC50:  24nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2020
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50205854(CHEMBL3891918)
Affinity DataEC50:  24nMAssay Description:Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) expressed in CHO cells assessed as increase in glutamate-induced calcium flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2018
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50344263((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...)
Affinity DataIC50: 29nMAssay Description:Antagonist activity at NR2A transfected in oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM86494(Perzinfotel | WAY-126090 | EAA-090)
Affinity DataIC50: 30nMAssay Description:Binding affinity to NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50528608(CHEMBL4555750)
Affinity DataEC50:  30nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50164380(CHEMBL3799878)
Affinity DataEC50:  30nMAssay Description:Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50528608(CHEMBL4555750)
Affinity DataEC50:  30nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50164380(CHEMBL3799878)
Affinity DataEC50:  30nMAssay Description:Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) expressed in CHO cells assessed as increase in glutamate-induced calcium flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2018
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM521564(US11149054, Compound 1-B)
Affinity DataEC50:  31.6nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50528623(CHEMBL4516765)
Affinity DataEC50:  33nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM521614(US11149054, Compound 5131)
Affinity DataEC50:  33.6nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM521682(US11149054, Compound 9062)
Affinity DataEC50:  34.5nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM521593(US11149054, Compound 3496)
Affinity DataEC50:  35.1nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50205849(CHEMBL3938522 | US10280165, Example 1)
Affinity DataEC50:  36.8nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2020
Entry Details
US Patent

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