Compile Data Set for Download or QSAR
Report error Found 268 of affinity data for UniProtKB/TrEMBL: Q16572
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50039613(trans-3-(4-phenylpiperidin-1-yl)-1,2,3,4-tetrahydr...)
Affinity DataKi:  0.0550nMAssay Description:Binding to vesicular acetylcholine transporter of torpedo synaptic vesiclesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50039613(trans-3-(4-phenylpiperidin-1-yl)-1,2,3,4-tetrahydr...)
Affinity DataKi:  0.0550nMAssay Description:Binding affinity to VAChTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50039613(trans-3-(4-phenylpiperidin-1-yl)-1,2,3,4-tetrahydr...)
Affinity DataKi:  0.0550nMAssay Description:Displacement of [3H]vesamicol from human vesicular acetylcholine transporter expressed in rat PC12 cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50039604((-)-1''-(3-Iodo-benzyl)-4-phenyl-[1,3'']bipiperidi...)
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]vesamicol from Vesicular Acetylcholine Transporter (VAChT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50039604((-)-1''-(3-Iodo-benzyl)-4-phenyl-[1,3'']bipiperidi...)
Affinity DataKi:  0.130nMAssay Description:Displacement of (-)-[3H]vesamicol from human VAChT expressed in rat PC12 A123.7 cells after 20 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50039604((-)-1''-(3-Iodo-benzyl)-4-phenyl-[1,3'']bipiperidi...)
Affinity DataKi:  0.130nMAssay Description:Binding to vesicular acetylcholine transporter of torpedo synaptic vesiclesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50046952(CHEMBL1956464 | CHEMBL129530 | trans-1-(4-fluorobe...)
Affinity DataKi:  0.220nMAssay Description:Displacement of (-)-[3H]vesamicol from human VAChT expressed in rat PC12 A123.7 cells after 20 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50046952(CHEMBL1956464 | CHEMBL129530 | trans-1-(4-fluorobe...)
Affinity DataKi:  0.220nMAssay Description:Binding affinity to VAChTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50046952(CHEMBL1956464 | CHEMBL129530 | trans-1-(4-fluorobe...)
Affinity DataKi:  0.220nMAssay Description:Displacement of [3H]vesamicol from human vesicular acetylcholine transporter expressed in rat PC12 cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50292908((+/-)-trans-2-Hydroxy-3-(4-(4-bromobenzoyl)piperid...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [3H]vesamicol from human vesicular acetylcholine transporter expressed in rat PC12 cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50079277(trans-trans-1-(3-iodobenzyl)-7-(4-phenylpiperidin-...)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]vesamicol from Vesicular Acetylcholine Transporter (VAChT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50079275([(4aR,6R,7R,8aR)-6-Hydroxy-7-(4-phenyl-piperidin-1...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]vesamicol from Vesicular Acetylcholine Transporter (VAChT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50366029(CHEMBL1956465)
Affinity DataKi:  0.320nMAssay Description:Binding affinity to VAchTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50039617(1-(4-fluorobenzyl)-3-spiro[2,3-dihydro-1H-indene-1...)
Affinity DataKi:  0.360nMAssay Description:Binding to vesicular acetylcholine transporter of torpedo synaptic vesiclesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50039621(3-spiro[2,3-dihydro-1H-indene-1,4'-(hexahydropyrid...)
Affinity DataKi:  0.360nMAssay Description:Binding to vesicular acetylcholine transporter of torpedo synaptic vesiclesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50079278((4aR,6R,7R,8aR)-1-((E)-3-Iodo-allyl)-7-(4-phenyl-p...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]vesamicol from Vesicular Acetylcholine Transporter (VAChT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50046952(CHEMBL1956464 | CHEMBL129530 | trans-1-(4-fluorobe...)
Affinity DataKi:  0.440nMAssay Description:Binding affinity to VAchTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50079276((4aR,6R,7R,8aR)-7-(4-Phenyl-piperidin-1-yl)-decahy...)
Affinity DataKi:  0.440nMAssay Description:Displacement of [3H]vesamicol from Vesicular Acetylcholine Transporter (VAChT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50046952(CHEMBL1956464 | CHEMBL129530 | trans-1-(4-fluorobe...)
Affinity DataKi:  0.440nMAssay Description:Binding to vesicular acetylcholine transporter of torpedo synaptic vesiclesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50292905((2R,3R)-5-(3-iodoallyloxy)-3-(4-phenylpiperidin-1-...)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]vesamicol from human vesicular acetylcholine transporter expressed in rat PC12 cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50292910((+/-)-trans-2-Hydroxy-3-(4-(4-nitrobenzoyl)piperid...)
Affinity DataKi:  0.480nMAssay Description:Displacement of [3H]vesamicol from human vesicular acetylcholine transporter expressed in rat PC12 cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50039609(1-(3-iodobenzyl)-3-spiro[2,3-dihydro-1H-indene-1,4...)
Affinity DataKi:  0.670nMAssay Description:Binding to vesicular acetylcholine transporter of torpedo synaptic vesiclesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50292906((2R,3R)-5-(3-fluoropropoxy)-3-(4-phenylpiperidin-1...)
Affinity DataKi:  0.770nMAssay Description:Displacement of [3H]vesamicol from human vesicular acetylcholine transporter expressed in rat PC12 cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50437713(CHEMBL2409366)
Affinity DataKi:  0.780nMAssay Description:Displacement of (-)-[3H]vesamicol from human VAChT expressed in rat PC12 cell membrane after 20 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50108979(CHEMBL3597316)
Affinity DataKi:  0.870nMAssay Description:Displacement of [3H]-vesamicol from human VAChT after 24 hrs by by liquid scintillation spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50437722(CHEMBL2409373)
Affinity DataKi:  0.930nMAssay Description:Displacement of (-)-[3H]vesamicol from human VAChT expressed in rat PC12 cell membrane after 20 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50079274(trans-trans-1-(4-fluorobenzyl)-7-(4-phenylpiperidi...)
Affinity DataKi:  0.990nMAssay Description:Displacement of [3H]vesamicol from Vesicular Acetylcholine Transporter (VAChT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50361992(CHEMBL1939699)
Affinity DataKi: >1nMAssay Description:Binding affinity to VAChTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50299280(1'-benzyl-3-(3-fluoropropyl)-3H-spiro[[2]benzofura...)
Affinity DataKi: >1nMAssay Description:Binding affinity to VAChTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50108980(CHEMBL3597317)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]-vesamicol from human VAChT after 24 hrs by by liquid scintillation spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50334158(CHEMBL2314421 | CHEMBL1645202 | 1'-benzyl-3-(2-flu...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to VAChTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50108983(CHEMBL3597320)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]-vesamicol from human VAChT after 24 hrs by by liquid scintillation spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50292911((+/-)-trans-2-Hydroxy-3-(4-(4-aminobenzoyl)piperid...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]vesamicol from human vesicular acetylcholine transporter expressed in rat PC12 cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50292911((+/-)-trans-2-Hydroxy-3-(4-(4-aminobenzoyl)piperid...)
Affinity DataKi:  1.70nMAssay Description:Displacement of (-)-[3H]vesamicol from human VAChT expressed in rat PC12 cell membrane after 20 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50108978(CHEMBL3597315)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]-vesamicol from human VAChT after 24 hrs by by liquid scintillation spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50018094((1R,2R)-2-(4-Phenyl-piperidin-1-yl)-cyclohexanol |...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]vesamicol from Vesicular Acetylcholine Transporter (VAChT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50018094((1R,2R)-2-(4-Phenyl-piperidin-1-yl)-cyclohexanol |...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]vesamicol from human vesicular acetylcholine transporter expressed in rat PC12 cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50018094((1R,2R)-2-(4-Phenyl-piperidin-1-yl)-cyclohexanol |...)
Affinity DataKi:  2nMAssay Description:Binding to vesicular acetylcholine transporter of torpedo synaptic vesiclesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM413601(US10421722, Compound 9b)
Affinity DataKi:  2.30nMAssay Description:The binding affinity of a compound to VAChT was measured by competition against the binding of 5 nM [3H]Vesamicol to postnuclear supernatant prepared...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details
US Patent

TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM413600(US10421722, Compound 9a)
Affinity DataKi:  2.40nMAssay Description:The binding affinity of a compound to VAChT was measured by competition against the binding of 5 nM [3H]Vesamicol to postnuclear supernatant prepared...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details
US Patent

TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM413594(US10421722, Compound 3)
Affinity DataKi:  2.40nMAssay Description:The binding affinity of a compound to VAChT was measured by competition against the binding of 5 nM [3H]Vesamicol to postnuclear supernatant prepared...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details
US Patent

TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50108986(CHEMBL3597324)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]-vesamicol from human VAChT after 24 hrs by by liquid scintillation spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50292907((+/-)-trans-2-Hydroxy-3-(4-(4-fluorobenzoyl)piperi...)
Affinity DataKi:  2.70nMAssay Description:Displacement of (-)-[3H]vesamicol from human VAChT expressed in rat PC12 cell membrane after 20 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50292902((2R,3R)-3-(4-(aminomethyl)-4-phenylpiperidin-1-yl)...)
Affinity DataKd:  3nMAssay Description:Displacement of [3H]vesamicol from human vesicular acetylcholine transporter expressed in rat PC12 cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50437721(CHEMBL2409374)
Affinity DataKi:  3nMAssay Description:Displacement of (-)-[3H]vesamicol from human VAChT expressed in rat PC12 cell membrane after 20 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50292907((+/-)-trans-2-Hydroxy-3-(4-(4-fluorobenzoyl)piperi...)
Affinity DataKi:  4.10nMAssay Description:Displacement of [3H]vesamicol from human vesicular acetylcholine transporter expressed in rat PC12 cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50292909(CHEMBL1186644 | CHEMBL473546 | (+/-)-trans-2-Hydro...)
Affinity DataKi:  4.30nMAssay Description:Displacement of (-)-[3H]vesamicol from human VAChT expressed in rat PC12 cell membrane after 20 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50292909(CHEMBL1186644 | CHEMBL473546 | (+/-)-trans-2-Hydro...)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]vesamicol from human vesicular acetylcholine transporter expressed in rat PC12 cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50018094((1R,2R)-2-(4-Phenyl-piperidin-1-yl)-cyclohexanol |...)
Affinity DataKi:  4.40nMAssay Description:Displacement of (-)-[3H]vesamicol from human VAChT expressed in rat PC12 A123.7 cells after 20 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50108981(CHEMBL3597318)
Affinity DataKi:  4.60nMAssay Description:Displacement of [3H]-vesamicol from human VAChT after 24 hrs by by liquid scintillation spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
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