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TargetLysine-specific histone demethylase 1A/REST corepressor 1(Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50155773(US9469597, 5 | CHEMBL3781751)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of recombinant human KDM1A/CoREST complex expressed in Escherichia coli using [Lys(Me1)4]-Histone H3 (1 to 21 residues)-GGK(biotin) as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A/REST corepressor 1(Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM254603(US9670136, 3 (trans)-N1-((1S,2R)-2-phenylcycloprop...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant human KDM1A/CoREST complex expressed in Escherichia coli using biotinylated H3K4me1 peptide as substrate preincubated for 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2019
Entry Details Article
PubMed
TargetREST corepressor 1(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50568523(CHEMBL4875015)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of N-terminal His-SUMO tagged human LSD1 (172 to 852 residues)/His-tagged CoREST (286 to 482 residues) expressed in Escherichia coli BL21 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetREST corepressor 1(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50153586(CHEMBL3775474 | US10053456, 120 | US9718814, 71 | ...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of recombinant human LSD1 (172 to 852 residues)/His-tagged human CoREST (286 to 482 residues) expressed in Escherichia coli BL21 (DE3) cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetREST corepressor 1(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50410785(CHEMBL5291155)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human recombinant LSD1/CoREST using ART(mK)QTARKSTGGKAPRKQLAGGK-biotin as substrate incubated for 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetREST corepressor 1(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50410784(CHEMBL5280566)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of human recombinant LSD1/CoREST using ART(mK)QTARKSTGGKAPRKQLAGGK-biotin as substrate incubated for 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetREST corepressor 1 [4-485](Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50155773(US9469597, 5 | CHEMBL3781751)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of human recombinant KDM1A/CoREST expressed in Escherichia coli using mono-methylated H3-K4 peptide as substrate assessed as H2O2 release ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2017
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A/REST corepressor 1(Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50236447(CHEMBL4069817)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of recombinant human KDM1A/CoREST complex expressed in Escherichia coli using [Lys(Me1)4]-Histone H3 (1 to 21 residues)-GGK(biotin) as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetREST corepressor 1(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50410789(CHEMBL5277056)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of human recombinant LSD1/CoREST using ART(mK)QTARKSTGGKAPRKQLAGGK-biotin as substrate incubated for 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetREST corepressor 1(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50621408(CHEMBL5399284)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of recombinant human LSD1 (172 to 852 residues)/His-tagged human CoREST (286 to 482 residues) expressed in Escherichia coli BL21 (DE3) cel...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A/REST corepressor 1(Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50236444(CHEMBL4090812)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of recombinant human KDM1A/CoREST complex expressed in Escherichia coli using [Lys(Me1)4]-Histone H3 (1 to 21 residues)-GGK(biotin) as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific histone demethylase 1A/REST corepressor 1(Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50236441(CHEMBL4072541)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of recombinant human KDM1A/CoREST complex expressed in Escherichia coli using [Lys(Me1)4]-Histone H3 (1 to 21 residues)-GGK(biotin) as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2019
Entry Details Article
PubMed
TargetREST corepressor 1(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50410788(CHEMBL5281376)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant LSD1/CoREST using ART(mK)QTARKSTGGKAPRKQLAGGK-biotin as substrate incubated for 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetREST corepressor 1(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50621404(CHEMBL5421067)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human LSD1 (172 to 852 residues)/His-tagged human CoREST (286 to 482 residues) expressed in Escherichia coli BL21 (DE3) cel...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetREST corepressor 1(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50262048(CHEMBL3134377)
Affinity DataKd:  14nMAssay Description:Binding affinity to human LSD1/CoREST assessed as dissociation constant by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A/REST corepressor 1(Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50236456(CHEMBL4081995)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human KDM1A/CoREST complex expressed in Escherichia coli using [Lys(Me1)4]-Histone H3 (1 to 21 residues)-GGK(biotin) as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetREST corepressor 1 [4-485](Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50155579(CHEMBL3546846)
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant KDM1A/CoREST expressed in Escherichia coli using mono-methylated H3-K4 peptide as substrate assessed as H2O2 release ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2017
Entry Details Article
PubMed
TargetREST corepressor 1(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50403543(CHEMBL5276713)
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant human LSD1/CoREST by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A/REST corepressor 1(Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50236457(CHEMBL4074211)
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant human KDM1A/CoREST complex expressed in Escherichia coli using [Lys(Me1)4]-Histone H3 (1 to 21 residues)-GGK(biotin) as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2019
Entry Details Article
PubMed
TargetREST corepressor 1 [4-485](Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50155763(CHEMBL3780391)
Affinity DataIC50: 23nMAssay Description:Inhibition of human recombinant KDM1A/CoREST expressed in Escherichia coli using mono-methylated H3-K4 peptide as substrate assessed as H2O2 release ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2017
Entry Details Article
PubMed
TargetREST corepressor 1(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50410786(CHEMBL5270114)
Affinity DataIC50: 24nMAssay Description:Inhibition of human recombinant LSD1/CoREST using ART(mK)QTARKSTGGKAPRKQLAGGK-biotin as substrate incubated for 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetREST corepressor 1 [4-485](Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50155766(CHEMBL3780374)
Affinity DataIC50: 28nMAssay Description:Inhibition of human recombinant KDM1A/CoREST expressed in Escherichia coli using mono-methylated H3-K4 peptide as substrate assessed as H2O2 release ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2017
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A/REST corepressor 1(Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50236451(CHEMBL4080514)
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant human KDM1A/CoREST complex expressed in Escherichia coli using [Lys(Me1)4]-Histone H3 (1 to 21 residues)-GGK(biotin) as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2019
Entry Details Article
PubMed
TargetREST corepressor 1(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50498143(CHEMBL3407602)
Affinity DataIC50: 31nMAssay Description:Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetREST corepressor 1 [4-485](Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50155767(CHEMBL3780524)
Affinity DataIC50: 34nMAssay Description:Inhibition of human recombinant KDM1A/CoREST expressed in Escherichia coli using mono-methylated H3-K4 peptide as substrate assessed as H2O2 release ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2017
Entry Details Article
PubMed
TargetREST corepressor 1(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50498128(CHEMBL3410944)
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetREST corepressor 1(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50262048(CHEMBL3134377)
Affinity DataKi:  35nMAssay Description:Inhibition of human LSD1/CoREST using histone H3 peptide as substrate by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetREST corepressor 1(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50498142(CHEMBL3407601)
Affinity DataIC50: 38nMAssay Description:Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetREST corepressor 1(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50458057(CHEMBL4210908)
Affinity DataKi:  40nMAssay Description:Inhibition of LSD1/CoREST (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetREST corepressor 1 [4-485](Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50155764(CHEMBL3780674)
Affinity DataIC50: 43nMAssay Description:Inhibition of human recombinant KDM1A/CoREST expressed in Escherichia coli using mono-methylated H3-K4 peptide as substrate assessed as H2O2 release ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2017
Entry Details Article
PubMed
TargetREST corepressor 1(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM256729(US9487511, 125 | US10053456, 125 | US9718814, 125 ...)
Affinity DataIC50: 46nMAssay Description:Inhibition of recombinant human LSD1 (172 to 852 residues)/His-tagged human CoREST (286 to 482 residues) expressed in Escherichia coli BL21 (DE3) cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetREST corepressor 1(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50498137(CHEMBL3410941)
Affinity DataIC50: 47nMAssay Description:Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetREST corepressor 1(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50346870(CHEMBL1797647)
Affinity DataKi:  50nMAssay Description:Inhibition of human GST-tagged LSD1/CoREST (305 to 482 residues) expressed in Escherichia coli using pLys4Met peptide as substrate by UV-visible spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A/REST corepressor 1 [4-485](Human)
Medical University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50346870(CHEMBL1797647)
Affinity DataKi:  50nMAssay Description:Inhibition of recombinant human LSD1/CoREST complex expressed in Escherichia coli using methylated H3-K4 peptide as substrate by peroxidase-coupled a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetREST corepressor 1 [4-485](Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50155768(CHEMBL3781494)
Affinity DataIC50: 51nMAssay Description:Inhibition of human recombinant KDM1A/CoREST expressed in Escherichia coli using mono-methylated H3-K4 peptide as substrate assessed as H2O2 release ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2017
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A/REST corepressor 1(Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50236468(CHEMBL4061143)
Affinity DataIC50: 56nMAssay Description:Inhibition of recombinant human KDM1A/CoREST complex expressed in Escherichia coli using [Lys(Me1)4]-Histone H3 (1 to 21 residues)-GGK(biotin) as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2019
Entry Details Article
PubMed
TargetREST corepressor 1(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50586370(CHEMBL5084197)
Affinity DataKi:  60nMAssay Description:Inhibition of human LSD1/CoRESTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetREST corepressor 1 [4-485](Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50155769(CHEMBL3780542)
Affinity DataIC50: 61nMAssay Description:Inhibition of human recombinant KDM1A/CoREST expressed in Escherichia coli using mono-methylated H3-K4 peptide as substrate assessed as H2O2 release ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2017
Entry Details Article
PubMed
TargetREST corepressor 1 [4-485](Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50155765(CHEMBL3781329)
Affinity DataIC50: 62nMAssay Description:Inhibition of human recombinant KDM1A/CoREST expressed in Escherichia coli using mono-methylated H3-K4 peptide as substrate assessed as H2O2 release ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2017
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A/REST corepressor 1(Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50236459(CHEMBL4100964)
Affinity DataIC50: 64nMAssay Description:Inhibition of recombinant human KDM1A/CoREST complex expressed in Escherichia coli using [Lys(Me1)4]-Histone H3 (1 to 21 residues)-GGK(biotin) as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2019
Entry Details Article
PubMed
TargetREST corepressor 1(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50594098(CHEMBL5198334)
Affinity DataKd:  64nMAssay Description:Binding affinity to human LSD1/CoREST assessed as dissociation constant by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetREST corepressor 1(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50410787(CHEMBL5270703)
Affinity DataIC50: 64nMAssay Description:Inhibition of human recombinant LSD1/CoREST using ART(mK)QTARKSTGGKAPRKQLAGGK-biotin as substrate incubated for 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A/REST corepressor 1(Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50236469(CHEMBL4083022)
Affinity DataIC50: 65nMAssay Description:Inhibition of recombinant human KDM1A/CoREST complex expressed in Escherichia coli using [Lys(Me1)4]-Histone H3 (1 to 21 residues)-GGK(biotin) as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A/REST corepressor 1(Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50236470(CHEMBL4099458)
Affinity DataIC50: 66nMAssay Description:Inhibition of recombinant human KDM1A/CoREST complex expressed in Escherichia coli using [Lys(Me1)4]-Histone H3 (1 to 21 residues)-GGK(biotin) as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2019
Entry Details Article
PubMed
TargetREST corepressor 1(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50594106(CHEMBL5202637)
Affinity DataKd:  67nMAssay Description:Binding affinity to human LSD1/CoREST assessed as dissociation constant by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetREST corepressor 1(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50594101(CHEMBL5175171)
Affinity DataKd:  68nMAssay Description:Binding affinity to human LSD1/CoREST assessed as dissociation constant by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetREST corepressor 1 [4-485](Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50155770(CHEMBL3781885)
Affinity DataIC50: 75nMAssay Description:Inhibition of human recombinant KDM1A/CoREST expressed in Escherichia coli using mono-methylated H3-K4 peptide as substrate assessed as H2O2 release ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2017
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A/REST corepressor 1(Human)
European Institute of Oncology

Curated by ChEMBL
LigandPNGBDBM50236467(CHEMBL4073106)
Affinity DataIC50: 75nMAssay Description:Inhibition of recombinant human KDM1A/CoREST complex expressed in Escherichia coli using [Lys(Me1)4]-Histone H3 (1 to 21 residues)-GGK(biotin) as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2019
Entry Details Article
PubMed
TargetREST corepressor 1(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50594085(CHEMBL5178765)
Affinity DataKd:  75nMAssay Description:Binding affinity to human LSD1/CoREST assessed as dissociation constant by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetREST corepressor 1(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50498150(CHEMBL3407599)
Affinity DataIC50: 79nMAssay Description:Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
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