PMID

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Article Title

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Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH

Jagiellonian University Medical College

Exploring new scaffolds for angiotensin II receptor antagonism.

National Hellenic Research Foundation

Mimicking of Arginine by Functionalized N(¿)-Carbamoylated Arginine As a New Broadly Applicable Approach to Labeled Bioactive Peptides: High Affinity Angiotensin, Neuropeptide Y, Neuropeptide FF, and Neurotensin Receptor Ligands As Examples.

University of Regensburg

Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.

Jagiellonian University Medical College

Interconversion of Functional Activity by Minor Structural Alterations in Nonpeptide AT2 Receptor Ligands.

Uppsala University

Saralasin and Sarile Are AT2 Receptor Agonists.

Universit£

Optimized protein kinase C¿ (PKC¿) inhibitors reveal only modest anti-inflammatory efficacy in a rodent model of arthritis.

Abbvie Bioresearch Center

Structure-activity relationship studies toward the discovery of selective apelin receptor agonists.

University of Strasburg

Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-¿.

Pfizer

The replacement of His(4) in angiotensin IV by conformationally constrained residues provides highly potent and selective analogues.

Vrije Universiteit Brussel

Synopsis of some recent tactical application of bioisosteres in drug design.

Bristol-Myers Squibb Pharmaceutical Research and Development

Chemokine receptor antagonists.

National Heart and Lung Institute

Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor.

Sanford-Burnham Medical Research Institute

The discovery of new potent non-peptide Angiotensin II AT1 receptor blockers: a concise synthesis, molecular docking studies and biological evaluation of N-substituted 5-butylimidazole derivatives.

University of Patras

Design, synthesis and biological activity of 6-substituted carbamoyl benzimidazoles as new nonpeptidic angiotensin II AT1 receptor antagonists.

School of Chemical Engineering & The Environment

Synthesis and biological evaluation of 4'-[(benzimidazole-1-yl)methyl]biphenyl-2-sulfonamide derivatives as dual angiotensin II/endothelin A receptor antagonists.

China Pharmaceutical University

Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity rela

Pfizer

Selective angiotensin II AT(2) receptor agonists with reduced CYP 450 inhibition.

Uppsala University

Designed multiple ligands. An emerging drug discovery paradigm.

Organon Laboratories

Angiotensin II AT1 receptor antagonists. Clinical implications of active metabolites.

Technische Universit£T Darmstadt

Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.

Dupont Pharmaceuticals

Novel cyclic analogs of angiotensin II with cyclization between positions 5 and 7: conformational and biological implications.

Washington University

Design, synthesis and biological evaluation of 6-substituted aminocarbonyl benzimidazole derivatives as nonpeptidic angiotensin II AT1 receptor antagonists.

Beijing Institute of Technology

Application of Ullmann and Ullmann-Finkelstein reactions for the synthesis of N-aryl-N-(1H-pyrazol-3-yl) acetamide or N-(1-aryl-1H-pyrazol-3-yl) acetamide derivatives and pharmacological evaluation.

University of Lille

Discovery of a series of imidazo[4,5-b]pyridines with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-¿.

Pfizer

Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.

The M. S. University of Baroda

Spiroindolones, a potent compound class for the treatment of malaria.

Swiss Tropical and Public Health Institute

A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase.

Università

The amino-terminus of angiotensin II contacts several ectodomains of the angiotensin II receptor AT1.

Universite De Sherbrooke

Synthesis and biological activities of novel indole derivatives as potent and selective PPARgamma modulators.

Glaxosmithkline

 

The SAR of 6-(N-alkyl-N-acyl)-2-propyl-3-[(2′-tetrazol-5-yl)biphen-4-yl)methyl]-quinazolinones as balanced affinity antagonists of the human AT₁ and AT₂ receptors

TBA

 

D and L-N-[(1-benzyl-1H-imidazol-5-yl)-alkyl]-amino acids as angiotensin II AT-1 antagonists

TBA

 

Potent triazolinone-based angiotensin II receptor antagonists with equivalent affinity for both the AT₁ and AT₂ subtypes

TBA

 

Development of angiotensin II antagonists with equipotent affinity for human AT₁ and AT₂ receptor subtypes.

TBA

 

Balanced angiotensin II receptor antagonists. III. The effects of substitution at the imidazole 5-position.

TBA

 

Balanced angiotensin II receptor antagonists. II.^1,2 4-aminomethyl- and acylaminomethylimidazoles

TBA

 

Imidazolinones as nonpeptide angiotensin II receptor antagonists

TBA

 

Valsartan, a potent, orally active angiotensin II antagonist developed from the structurally new amino acid series

TBA

 

A potent long-acting imidazole-5-acrylic acid angiotensin II AT-1 receptor antagonist

TBA

2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands.

Uppsala University

Quercetin derivatives: Drug design, development, and biological activities, a review.

Mazandaran University of Medical Sciences

Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds.

Uppsala University

Selective Discovery of GPCR Ligands within DNA-Encoded Chemical Libraries Derived from Natural Products: A Case Study on Antagonists of Angiotensin II Type I Receptor.

Northwest University

Discovery of Irbesartan Derivatives as BLT2 Agonists by Virtual Screening.

Fraunhofer Institute For Translational Medicine and Phamacology Itmp

Recognition of privileged structures by G-protein coupled receptors.

Novo Nordisk

Pyrazole Agonist of the Apelin Receptor Improves Symptoms of Metabolic Syndrome in Mice.

Rti International

Using conformational constraints at position 6 of Angiotensin II to generate compounds with enhanced AT2R selectivity and proteolytic stability.

Vrije Universiteit Brussel

Comparison of 3D structures and AT(1) binding properties of pyrazolidine-3,5-diones and tetrahydropyridazine-3,6-diones with parent antihypertensive drug irbesartan.

Université

Discovery of N-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists.

Bristol-Myers Squibb Pharmaceutical Research Institute

Novel human metabolites of the angiotensin-II antagonist tasosartan and their pharmacological effects.

Wyeth Research

N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands.

Uppsala University

Identification of potent pyrazole based APELIN receptor (APJ) agonists.

Rti International

Synthesis and pharmacological evaluation of new pyrazolidine-3, 5-diones as AT(1) angiotensin II receptor antagonists.

Université

Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure-Functional Selectivity Relationships (SFSRs) and Therapeutic Potential.

Shanghaitech University

The Other Angiotensin II Receptor: AT

Centre Hospitalier Universitaire Vaudois (Chuv) and University of Lausanne (Unil

Multitarget PPAR? agonists as innovative modulators of the metabolic syndrome.

University of Chieti "G. D.Annunzio

Identification of BR101549 as a lead candidate of non-TZD PPAR? agonist for the treatment of type 2 diabetes: Proof-of-concept evaluation and SAR.

Boryung Pharmaceuticals

Hydroxyl Groups in Synthetic and Natural-Product-Derived Therapeutics: A Perspective on a Common Functional Group.

University of Basel

Discovery of TD-0212, an Orally Active Dual Pharmacology AT

Theravance Biopharma Us

Benzazaborinines as Novel Bioisosteric Replacements of Naphthalene: Propranolol as an Example.

Janssen Pharmaceutica

Discovery of novel, potent and low-toxicity angiotensin II receptor type 1 (AT1) blockers: Design, synthesis and biological evaluation of 6-substituted aminocarbonyl benzimidazoles with a chiral center.

Beijing Institute of Technology

Design, synthesis, and biological evaluation of 1,2,4-triazole bearing 5-substituted biphenyl-2-sulfonamide derivatives as potential antihypertensive candidates.

China Pharmaceutical University

Nonpeptidic angiotensin II AT? receptor antagonists derived from 6-substituted aminocarbonyl and acylamino benzimidazoles.

Beijing Institute of Technology

Rational design, efficient syntheses and biological evaluation of N,N'-symmetrically bis-substituted butylimidazole analogs as a new class of potent Angiotensin II receptor blockers.

University of Patras

Novel angiotensin II receptor antagonists. Design, synthesis, and in vitro evaluation of dibenzo[a,d]cycloheptene and dibenzo[b,f]oxepin derivatives. Searching for bioisosteres of biphenylyltetrazole using a three-dimensional search technique.

Shionogi

Potent and orally active angiotensin II receptor antagonists with equal affinity for human AT1 and AT2 subtypes.

Merck Research Laboratories

Beta-homo-amino acid scan of angiotensin IV.

Vrije Universiteit Brussel

Fibrogenic Disorders in Human Diseases: From Inflammation to Organ Dysfunction.

Universitaire Vaudois

Discovery of the bifunctional modulator of angiotensin II type 1 receptor (AT1R) and PPAR? derived from the AT1R antagonist, Fimasartan.

Boryung Pharmaceuticals

Integration of multi-scale molecular modeling approaches with experiments for the in silico guided design and discovery of novel hERG-Neutral antihypertensive oxazalone and imidazolone derivatives and analysis of their potential restrictive effects on cell proliferation.

Bahcesehir University (Bau)

Identification and biological evaluation of thiazole-based inverse agonists of ROR?t.

Phenex Pharmaceuticals

High accuracy in silico sulfotransferase models.

Albert Einstein College of Medicine

Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease.

Yogi Vemana University

Phosphorylation of Capsaicinoid Derivatives Provides Highly Potent and Selective Inhibitors of the Transcription Factor STAT5b.

University of Leipzig

1,3-disubstituted-4-aminopyrazolo [3, 4-d] pyrimidines, a new class of potent inhibitors for phospholipase D.

University of Massachusetts Boston