PMID

Data

Article Title

Organization

3-Benzamides and 3,4,5-trimethoxyphenyl amines as calcium channel blockers.

Ewha Womans University

Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112).

Janssen Pharmaceutical Companies of Johnson & Johnson

Synthesis and SAR of 4-aminocyclopentapyrrolidines as orally active N-type calcium channel inhibitors for inflammatory and neuropathic pain.

Abbvie

Modular, efficient synthesis of asymmetrically substituted piperazine scaffolds as potent calcium channel blockers.

University of British Columbia

Synthesis and biological evaluation of a selective N- and p/q-type calcium channel agonist.

TBA

Aminopiperidine sulfonamide Cav2.2 channel inhibitors for the treatment of chronic pain.

Merck Research Laboratories

Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca²¿ channel blockers with analgesic activity.

Abbott Laboratories

Discovery and evaluation of selective N-type calcium channel blockers: 6-unsubstituted-1,4-dihydropyridine-5-carboxylic acid derivatives.

Ajinomoto Pharmaceuticals

Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.

Johnson & Johnson Pharmaceutical Research & Development

A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.

Abbott Laboratories

Design, synthesis, and preliminary pharmacological evaluation of 4-aminopiperidine derivatives as N-type calcium channel blockers active on pain and neuropathic pain.

Universit£

(S)-4-Methyl-2-(methylamino)pentanoic acid [4, 4-bis(4-fluorophenyl)butyl]amide hydrochloride, a novel calcium channel antagonist, is efficacious in several animal models of pain.

Pfizer

In vivo evaluation of oral anti-tumoral effect of 3,4-dihydroquinazoline derivative on solid tumor.

Kyung Hee University

Pyridyl amides as potent inhibitors of T-type calcium channels.

Merck Research Laboratories

A potent and selective indole N-type calcium channel (Ca(v)2.2) blocker for the treatment of pain.

Merck Research Laboratories

Design, syntheses, and SAR of 2,8-diazaspiro[4.5]decanones as T-type calcium channel antagonists.

Icagen

Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives.

Abbott Laboratories

Synthesis and biological evaluation of 1,4-diazepane derivatives as T-type calcium channel blockers.

Institute of Science and Technology

Omega-conotoxin GVIA mimetics based on an anthranilamide core: effect of variation in ammonium side chain lengths and incorporation of fluorine.

The University of Queensland

Low molecular weight non-peptide mimics of omega-conotoxin GVIA.

Csiro Molecular and Health Technologies

Synthesis and SAR of novel 2-arylthiazolidinones as selective analgesic N-type calcium channel blockers.

Ionix Pharmaceuticals

Discovery of a novel, orally active, small molecule gonadotropin-releasing hormone (GnRH) receptor antagonist.

Pfizer

Inhibition of N-type calcium ion channels by tricyclic antidepressants - experimental and theoretical justification for their use for neuropathic pain.

The University of Queensland

Synthesis and Preclinical Characterization of LY3154885, a Human Dopamine D1 Receptor Positive Allosteric Modulator with an Improved Nonclinical Drug-Drug Interaction Risk Profile.

TBA

The neuronal calcium ion channel activity of constrained analogues of MONIRO-1.

The University of Queensland

L-Cysteine based N-type calcium channel blockers: structure-activity relationships of the C-terminal lipophilic moiety, and oral analgesic efficacy in rat pain models.

Minase Research Institute

Structure-activity study of L-cysteine-based N-type calcium channel blockers: optimization of N- and C-terminal substituents.

Minase Research Institute

Structure-activity study and analgesic efficacy of amino acid derivatives as N-type calcium channel blockers.

No Pharmaceutical

Design and biological evaluation of non-peptide analogues of omega-conotoxin MVIIA.

Parke-Davis Neuroscience Research Centre

Synthesis of a series of 4-benzyloxyaniline analogues as neuronal N-type calcium channel blockers with improved anticonvulsant and analgesic properties.

Warner-Lambert

Structure-activity relationship at the proximal phenyl group in a series of non-peptidyl N-type calcium channel antagonists.

Parke-Davis Pharmaceutical Research

Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers.

Warner-Lambert

Structure-activity relationship of N-methyl-N-aralkyl-peptidylamines as novel N-type calcium channel blockers.

Warner-Lambert

Multiple parallel synthesis of N,N-dialkyldipeptidylamines as N-type calcium channel blockers.

Warner-Lambert

Synthesis and biological evaluation of substituted 4-(OBz)phenylalanine derivatives as novel N-type calcium channel blockers.

Warner-Lambert

N,N-dialkyl-dipeptidylamines as novel N-type calcium channel blockers.

Warner-Lambert

Synthesis and structure-activity relationship of substituted 1,2,3,4-tetrahydroisoquinolines as N-type calcium channel blockers.

Warner-Lambert

Scaffold-based design and synthesis of potent N-type calcium channel blockers.

University of Calgary

Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors.

Neuromed Pharmaceuticals

Structure-activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels.

Ajinomoto

Discovery and optimization of a novel series of pyrazolyltetrahydropyran N-type calcium channel (Ca

Janssen Research & Development

Synthesis and evaluation of aminobenzothiazoles as blockers of N- and T-type calcium channels.

Iitb-Monash Research Academy

Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies.

Idorsia Pharmaceuticals

Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease.

Yogi Vemana University

Phosphorylation of Capsaicinoid Derivatives Provides Highly Potent and Selective Inhibitors of the Transcription Factor STAT5b.

University of Leipzig

A major role for a set of non-active site mutations in the development of HIV-1 protease drug resistance.

The Johns Hopkins University