PMID

Data

Article Title

Organization

Discovery of KDM5A inhibitors: Homology modeling, virtual screening and structure-activity relationship analysis.

Sichuan University

Recent Progress in Histone Demethylase Inhibitors.

University of Oxford

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives.

Glaxosmithkline

Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors.

University of Oxford

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.

The Institute of Cancer Research

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives.

Glaxosmithkline

Design and discovery of new pyrimidine coupled nitrogen aromatic rings as chelating groups of JMJD3 inhibitors.

Chinese Academy of Sciences

Quantitative analysis of histone demethylase probes using fluorescence polarization.

University of Colorado

Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.

University of Oxford

Lysine demethylases inhibitors.

Kyoto Prefectural University of Medicine

Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors.

University of Oxford

Recent Advances with KDM4 Inhibitors and Potential Applications.

St. Jude Children'S Research Hospital

Drug discovery of histone lysine demethylases (KDMs) inhibitors (progress from 2018 to present).

Hangzhou Normal University

First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53.

University of Oxford

Discovery of pyrazole derivatives as cellular active inhibitors of histone lysine specific demethylase 5B (KDM5B/JARID1B).

Zhengzhou University

Identification of the 2-Benzoxazol-2-yl-phenol Scaffold as New Hit for JMJD3 Inhibition.

Institute of Biomolecular Chemistry (Icb)

Identification of novel lysine demethylase 5-selective inhibitors by inhibitor-based fragment merging strategy.

Kyoto Prefectural University of Medicine

Identification of ortho-hydroxy anilide as a novel scaffold for lysine demethylase 5 inhibitors.

Kyoto Prefectural University of Medicine

C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.

Institute of Cancer Research

Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor.

University of Oxford

Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities.

Sapienza University of Rome

Structure-based design and discovery of potent and selective KDM5 inhibitors.

Celgene

Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models.

Celgene Quanticel Research

Pyridone derivatives as potent, orally bioavailable VLA-4 integrin antagonists.

Glaxosmithkline

Role of hydrophilic interaction in binding of hydroxylated 3-deoxy C(19) steroids to the active site of aromatase.

Tohoku Pharmaceutical University