PMID

Data

Article Title

Organization

Design, synthesis, and structure-activity relationships of tetrahydroquinoline-based farnesyltransferase inhibitors.

Bristol-Myers Squibb Pharmaceutical Research Institute

Modeling of binding modes and inhibition mechanism of some natural ligands of farnesyl transferase using molecular docking.

University of Milan

Successful virtual screening of a chemical database for farnesyltransferase inhibitor leads.

Mayo Medical School and Mayo Clinic

Structure-activity relationships of cysteine-lacking pentapeptide derivatives that inhibit ras farnesyltransferase.

Warner-Lambert

Ras farnesyltransferase: a new therapeutic target.

Warner-Lambert

 

Phenolic replacements for cysteine in farnesyl transferase inhibitors based on CVFM

TBA

 

Constrained analogs of KCVFM with improved inhibitory properties against farnesyl transferase

TBA

 

Stereochemistry of the benzodiazepine based Ras farnesyltransferase inhibitors

TBA

 

Peptide based P21^RAS farnesyl transferase inhibitors: systematic modification of the tetrapeptide CA₁A₂X motif

TBA

Evaluation of amino acid-based linkers in potent macrocyclic inhibitors of farnesyl-protein transferase.

Merck Research Laboratories

Diaryl ether inhibitors of farnesyl-protein transferase.

Merck Research Laboratories

Discovery of a series of cyclohexylethylamine-containing protein farnesyltransferase inhibitors exhibiting potent cellular activity.

Abbott Laboratories

Solid-phase synthesis of novel inhibitors of farnesyl transferase.

Institute of Cancer Research

Inhibitors of farnesyl protein transferase. 4-Amido, 4-carbamoyl, and 4-carboxamido derivatives of 1-(8-chloro-6,11-dihydro-5H-benzo[5,6]- cyclohepta[1,2-b]pyridin-11-yl)piperazine and 1-(3-bromo-8-chloro-6,11- dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperazine.

Schering-Plough Research Institute

A new class of highly potent farnesyl diphosphate-competitive inhibitors of farnesyltransferase.

Tsukuba Research Institute

C-terminal modifications of histidyl-N-benzylglycinamides to give improved inhibition of Ras farnesyltransferase, cellular activity, and anticancer activity in mice.

Warner-Lambert

Novel benzimidazole phosphonates as potential inhibitors of protein prenylation.

University of Iowa

2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase.

Merck Research Laboratories

Interrogating the Roles of Post-Translational Modifications of Non-Histone Proteins.

Temple University

Solvent and guest isotope effects on complexation thermodynamics of alpha-, beta-, and 6-amino-6-deoxy-beta-cyclodextrins.

Japan Science and Technology Agency

 

Thermodynamic Origin of Molecular Selective Binding of Bile Salts by Aminated β-Cyclodextrins

Nankai University