PMID

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Article Title

Organization

Recent Progress in Histone Demethylase Inhibitors.

University of Oxford

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives.

Glaxosmithkline

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.

The Institute of Cancer Research

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives.

Glaxosmithkline

Novel 5-carboxy-8-HQ based histone demethylase JMJD2A inhibitors: introduction of an additional carboxyl group at the C-2 position of quinoline.

China Pharmaceutical University

KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor.

National Tsing Hua University

Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity.

Kyoto Prefectural University of Medicine

Quantitative analysis of histone demethylase probes using fluorescence polarization.

University of Colorado

A small molecule inhibitor of fungal histone acetyltransferase Rtt109.

University of Massachusetts Medical School

Oncoepigenomics: making histone lysine methylation count.

TBA

Lysine demethylases inhibitors.

Kyoto Prefectural University of Medicine

Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.

Nagoya City University

Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.

University of Oxford

Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors.

University of Oxford

Recent Advances with KDM4 Inhibitors and Potential Applications.

St. Jude Children'S Research Hospital

Drug discovery of histone lysine demethylases (KDMs) inhibitors (progress from 2018 to present).

Hangzhou Normal University

Design, synthesis and biological evaluation of a novel spiro oxazolidinedione as potent p300/CBP HAT inhibitor for the treatment of ovarian cancer.

China Pharmaceutical University

First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53.

University of Oxford

Discovery of a potent and selective inhibitor of histone lysine demethylase KDM4D.

Nankai University

Discovery of pyrazole derivatives as cellular active inhibitors of histone lysine specific demethylase 5B (KDM5B/JARID1B).

Zhengzhou University

Rational design, synthesis and biological profiling of new KDM4C inhibitors.

Fidelta

Identification of novel lysine demethylase 5-selective inhibitors by inhibitor-based fragment merging strategy.

Kyoto Prefectural University of Medicine

Identification of ortho-hydroxy anilide as a novel scaffold for lysine demethylase 5 inhibitors.

Kyoto Prefectural University of Medicine

New Modalities, Technologies, and Partnerships in Probe and Lead Generation: Enabling a Mode-of-Action Centric Paradigm.

Astrazeneca

C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.

Institute of Cancer Research

Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor.

University of Oxford

Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.

The University of Texas M.D. Anderson Cancer Center

Structure-based design and discovery of potent and selective KDM5 inhibitors.

Celgene

Targeting lysine specific demethylase 4A (KDM4A) tandem TUDOR domain - A fragment based approach.

Abbvie

Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models.

Celgene Quanticel Research

Structure-activity studies of a macrocyclic peptide inhibitor of histone lysine demethylase 4A.

The University of Tokyo

The mouse 5HT5 receptor reveals a remarkable heterogeneity within the 5HT1D receptor family.

Cnrs

 

Calorimetric Studies on the Complexation of Several Ferrocene Derivatives by .alpha.- and .beta.-Cyclodextrin. Effects of Urea on the Thermodynamic Parameters

University of Miami