PMID

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Design and synthesis of new potent PTP1B inhibitors with the skeleton of 2-substituted imino-3-substituted-5-heteroarylidene-1,3-thiazolidine-4-one: Part I.

Xi'An Jiaotong University

Is RK-682 a promiscuous enzyme inhibitor? Synthesis and in vitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues.

University of Campinas

Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B.

University of Pittsburgh

Synthesis and biological evaluation of novel thiadiazole amides as potent Cdc25B and PTP1B inhibitors.

Liaoning Normal University

Bioactive constituents from the green alga Caulerpa racemosa.

Nanchang University

Design, synthesis, and biological evaluation of novel 2-ethyl-5-phenylthiazole-4-carboxamide derivatives as protein tyrosine phosphatase 1B inhibitors with improved cellular efficacy.

Chinese Academy of Sciences

Design and synthesis of novel bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors: effect of dimerisation on phosphatase inhibition.

University of Paris

Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core Structure.

TBA

Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases.

Imperial College

Discovery of new inhibitors of Cdc25B dual specificity phosphatases by structure-based virtual screening.

Universit£

Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties.

University of Paris

Synthesis of the novel analogues of dysidiolide and their structure-activity relationship.

The University of Tokyo

Synthesis and biological evaluation of (±)-3-(2-(2-fluorobenzyloxy) naphthalen-6-yl)-2-aminopropanoic acid derivatives as novel PTP1B inhibitors.

Yanbian University

Facile fabrication of promising protein tyrosine phosphatase (PTP) inhibitor entities based on 'clicked' serine/threonine-monosaccharide hybrids.

East China University of Science and Technology

Using small molecules to target protein phosphatases.

Max Planck Institute of Molecular Physiology

A unique and rapid approach toward the efficient development of novel protein tyrosine phosphatase (PTP) inhibitors based on 'clicked' pseudo-glycopeptides.

East China University of Science and Technology

Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B.

Chinese Academy of Sciences

5-Substituted [1]pyrindine derivatives with antiproliferative activity.

University of Paris

Structure-based virtual screening approach to identify novel classes of Cdc25B phosphatase inhibitors.

Sejong University

Structure-based de novo design and biochemical evaluation of novel Cdc25 phosphatase inhibitors.

Sejong University

Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases.

Virginia Polytechnic Institute and State University

Discovery of novel Cdc25 phosphatase inhibitors with micromolar activity based on the structure-based virtual screening.

Sejong University

Tetramic and tetronic acids: an update on new derivatives and biological aspects.

University of Bayreuth

Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta.

Virginia Polytechnic Institute and State University

Fluorinated NSC as a Cdc25 inhibitor.

Sejong University

Synthesis and biological evaluation of dialkylsubstituted maleic anhydrides as novel inhibitors of Cdc25 dual specificity phosphatases.

Université

Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.

Graduate School of Chinese Academy of Sciences

PTP-1B inhibitors: cyclopenta[d][1,2]-oxazine derivatives.

Korea Research Institute of Chemical Technology

Chemistry, biosynthesis and biological activity of terpenoids and meroterpenoids in bacteria and fungi isolated from different marine habitats.

Iranian Fisheries Science Research Institute

Design and synthesis of novel Cdc25A-inhibitors having phosphate group as a hydrophilic residue.

The University of Tokyo

Design and synthesis of dysidiolide analogs from vitamin D3: novel class of Cdc25A inhibitors.

The University of Tokyo

Design and synthesis of macrocyclic inhibitors of phosphatase cdc25B.

Schering

Talaromynoids A-I, Highly Oxygenated Meroterpenoids from the Marine-Derived Fungus

Chinese Academy of Sciences

Design, synthesis, and functional evaluation of triazine-based bivalent agents that simultaneously target the active site and hot spot of phosphatase Cdc25B.

Shinshu University

Inhibition of Cdc25 phosphatases by indolyldihydroxyquinones.

Duke University

Synthesis and PTP1B inhibition of 1,2-naphthoquinone derivatives as potent anti-diabetic agents.

Korea Research Institute of Chemical Technology

Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25.

University of Pittsburgh

Sulfonylated aminothiazoles as new small molecule inhibitors of protein phosphatases.

University of Pittsburgh

The solid phase synthesis of tetrahydroisoquinolines having cdc25B inhibitory activity.

Pharmacia & Upjohn

Dysidiolide and related gamma-hydroxy butenolide compounds as inhibitors of the protein tyrosine phosphatase, CDC25.

Mitotix

Synthesis and biological evaluation of tryptophan-derived rhodanine derivatives as PTP1B inhibitors and anti-bacterial agents.

Yanbian University College of Pharmacy

Discovery of 1,3-diphenyl-1H-pyrazole derivatives containing rhodanine-3-alkanoic acid groups as potential PTP1B inhibitors.

Yanbian University

Synthesis, anticancer activity, and molecular modeling of 1,4-naphthoquinones that inhibit MKK7 and Cdc25.

Montana State University

Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries.

Shandong University

Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines.

University of Naples Federico Ii

Structure-based development of novel triazoles and related thiazolotriazoles as anticancer agents and Cdc25A/B phosphatase inhibitors. Synthesis, in vitro biological evaluation, molecular docking and in silico ADME-T studies.

King Abdulaziz University

Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells.

Sapienza University of Rome

Solution phase synthesis of a combinatorial library of chalcones and flavones as potent cathepsin V inhibitors.

Universidade Federal De SaO Carlo

Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1a prolyl hydroxylases-1, -2, and -3 with altered selectivity.

Amgen

Strategy for discovering chemical inhibitors of human cyclophilin a: focused library design, virtual screening, chemical synthesis and bioassay.

East China Univesity of Science and Technology

Thiolactomycin-based ß-Ketoacyl-AcpM Synthase A (KasA) Inhibitors: FRAGMENT-BASED INHIBITOR DISCOVERY USING TRANSIENT ONE-DIMENSIONAL NUCLEAR OVERHAUSER EFFECT NMR SPECTROSCOPY.

Institute For Chemical Biology & Drug Discovery