PMID

Data

Article Title

Organization

Molecular hybridization yields triazole bronchodilators for the treatment of COPD.

Pfizer

Insights on the role of boron containing moieties in the design of new potent and efficient agonists targeting theß2 adrenoceptor.

Instituto Polit£Cnico Nacional (Ipn)

The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-actingß2-adrenoceptor agonist.

Novartis Institutes For Biomedical Research

Multivalent design of long-actingß(2)-adrenoceptor agonists incorporating biarylamines.

Theravance

Design, synthesis and evaluation of dual pharmacologyß2-adrenoceptor agonists and PDE4 inhibitors.

Sun Yat-Sen University

Synthesis of halogenated trimetoquinol derivatives and evaluation of their beta-agonist and thromboxane A2 (TXA2) antagonist activities.

Ohio State University

An investigation into the structure-activity relationships associated with the systematic modification of theß(2)-adrenoceptor agonist indacaterol.

Novartis Institutes For Biomedical Research

From libraries to candidate: the discovery of new ultra long-acting dibasicß2-adrenoceptor agonists.

Astrazeneca

The discovery of long-acting saligeninß2 adrenergic receptor agonists incorporating a urea group.

Glaxosmithkline

The discovery of long-acting saligeninß2 adrenergic receptor agonists incorporating hydantoin or uracil rings.

Glaxosmithkline

Synthesis and beta-adrenergic blocking activity of new aliphatic and alicyclic oxime ethers.

TBA

Beta 1-selective adrenoceptor antagonists: examples of the 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazole class.

TBA

Ultra-short-acting beta-adrenergic receptor blocking agents. 2. (Aryloxy)propanolamines containing esters on the aryl function.

TBA

Ultra-short-acting beta-adrenergic receptor blocking agents. 1. (Aryloxy)propanolamines containing esters in the nitrogen substituent.

TBA

2-Benzodioxinylaminoethanols: a new class of beta-adrenergic blocking and antihypertensive agents.

TBA

Synthesis and beta-adrenergic blocking activity of new aliphatic oxime ethers.

TBA

Synthesis, pharmacological and in silico evaluation of 1-(4-di-hydroxy-3,5-dioxa-4-borabicyclo[4.4.0]deca-7,9,11-trien-9-yl)-2-(tert-butylamino)ethanol, a compound designed to act as a beta2 adrenoceptor agonist.

Instituto Polit£Cnico Nacional (Ipn)

Nitric oxide donor beta2-agonists: furoxan derivatives containing the fenoterol moiety and related furazans.

Universit£

Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.

Smithkline Beecham Pharmaceuticals

Conformationally restrained analogs of sympathomimetic catecholamines. Synthesis, conformational analysis, and adrenergic activity of isochroman derivatives.

Universit£

Synthesis and hypoglycemic activity of substituted 8-(1-piperazinyl)imidazo[1,2-a]pyrazines.

Merck Sharp and Dohme Research Laboratories

Dualß2-adrenoceptor agonists-PDE4 inhibitors for the treatment of asthma and COPD.

Sun Yat-Sen University

Inhalation by design: dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD.

Pfizer

Discovery of substituted phenyl urea derivatives as novel long-actingß2-adrenoreceptor agonists.

RhôNe-Poulenc Rorer

The identification of indacaterol as an ultralong-acting inhaled beta2-adrenoceptor agonist.

Novartis Institutes For Biomedical Research

Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and ?

Chiesi Farmaceutici

Synthesis and preliminary evaluation of (R,R)(S,S) 5-(2-(2-[4-(2-[(18)F]fluoroethoxy)phenyl]-1-methylethylamino)-1-hydroxyethyl)-benzene-1,3-diol ([(18)F]FEFE) for the in vivo visualisation and quantification of the beta2-adrenergic receptor status in lung.

University of Mainz

Synthesis, Purification, and Selective ?

Shandong University

The [(methyloxy)imino]methyl moiety as a bioisoster of aryl. A novel class of completely aliphatic beta-adrenergic receptor antagonists.

Universitá

A new series of tricyclic (aryloximino)propanolamines displaying very high selective beta 2-blocking properties.

Université

Effect of fluorine substitution on the adrenergic properties of 3-(tert-butylamino)-1-(3,4-dihydroxyphenoxy)-2-propanol.

National Institute of Diabetes