31 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
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Pseudodeflectusin, a novel isochroman derivative from Aspergillus pseudodeflectus a parasite of the sea weed, Sargassum fusiform, as a selective human cancer cytotoxin.
Tokyo University of Science
Part 1: Notch-sparing¿-secretase inhibitors: The identification of novel naphthyl and benzofuranyl amide analogs.
Harvard Medical School
Synthesis of pyrimido[4,5-c]azepine- and pyrimido[4,5-c]oxepine-based¿-secretase modulators.
Bristol-Myers Squibb
Design and optimization of tricyclic gamma-secretase modulators.
Bristol-Myers Squibb Research and Development
Discovery of a Novel, Potent Spirocyclic Series of¿-Secretase Inhibitors.
Merck Research Laboratories
Potent benzoazepinone¿-secretase modulators with improved bioavailability.
Merck Research Laboratories
Discovery of indole-derived pyridopyrazine-1,6-dione¿-secretase modulators that target presenilin.
Pfizer
Design of Pyridopyrazine-1,6-dione¿-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability.
Pfizer
SAR-studies of¿-secretase modulators with PPAR¿-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease.
Goethe-University Frankfurt
Stereochemical analysis of (hydroxyethyl)urea peptidomimetic inhibitors of gamma-secretase.
Harvard Medical School
Probing pockets S2-S4' of the gamma-secretase active site with (hydroxyethyl)urea peptidomimetics.
Harvard Medical School
Synthesis of biotinylated photoaffinity probes based on arylsulfonamide gamma-secretase inhibitors.
University of Tokyo
3-Substituted gem-cyclohexane sulfone based gamma-secretase inhibitors for Alzheimer's disease: conformational analysis and biological activity.
Merck Sharp and Dohme Research Laboratories
Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates.
University of Tokyo
3,4-Fused cyclohexyl sulfones as gamma-secretase inhibitors.
Neuroscience Research Centre
Cyclic sulfamide gamma-secretase inhibitors.
Merck Sharp and Dohme Research Laboratories
Structural modification aimed for improving solubility of lead compounds in early phase drug discovery.
Indian Institute of Technology (B.H.U.)
Aryl sulfones: a new class of gamma-secretase inhibitors.
Merck Sharp & Dohme Research Laboratories
A novel series of potent gamma-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core.
Merck Sharp & Dohme Research Laboratories
Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase.
Harvard Medical School
Design of Transmembrane Mimetic Structural Probes to Trap Different Stages of ?-Secretase-Substrate Interaction.
University of Kansas
High affinity, bioavailable 3-amino-1,4-benzodiazepine-based gamma-secretase inhibitors.
Merck Sharp & Dohme Research Laboratories
Inhibitors of Abeta production: solid-phase synthesis and SAR of alpha-hydroxycarbonyl derivatives.
Bristol-Myers Squibb Pharmaceutical Research Institute
Discovery of Orally Active Hydroxyethylamine Based SPPL2a Inhibitors.
Novartis Institutes For Biomedical Research
Discovery of N-ethylpyridine-2-carboxamide derivatives as a novel scaffold for orally active ?-secretase modulators.
Astellas Pharma
Discovery of novel scaffolds for ?-secretase modulators without an arylimidazole moiety.
Astellas Pharma
Discovery of a Tetrahydrobenzisoxazole Series of ?-Secretase Modulators.
Merck Research Laboratories