PMID

Data

Article Title

Organization

Mammalian topoisomerase II inhibitory activity of 1-cyclopropyl-6,8- difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarb oxylic acid and related derivatives.

Sterling Winthrop Pharmaceuticals Research Division

Synthesis and antibacterial activity of new tetracyclic quinolone antibacterials.

Kanebo

Synthesis and bacterial DNA gyrase inhibitory properties of a spirocyclopropylquinolone derivative.

Sterling-Winthrop Research Institute

Chiral DNA gyrase inhibitors. 2. Asymmetric synthesis and biological activity of the enantiomers of 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H- pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (ofloxacin).

Kansas University

Novel quinazoline-quinoline alkaloids with cytotoxic and DNA topoisomerase II inhibitory activities.

Toho University

Design, synthesis and structure-activity relationship studies of novel indazole analogues as DNA gyrase inhibitors with Gram-positive antibacterial activity.

Dainippon Pharmaceutical

Synthesis and biological testing of non-fluorinated analogues of levofloxacin.

Procter & Gamble Pharmaceuticals

Preparation of 5-(2,6-dideoxy-2-fluoro-alpha-L-talopyranosyloxy)-6-hydroxynap htho[2,3- f]quinoline-7,12-dione (FT-Alz), a new-type, potentially antitumor substance with various biological activities.

Institute of Bioorganic Chemistry

 

The antitumor activity of novel pyrazoloquinoline derivatives

TBA

Structure-Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase II? Interactions.

Charles University

Inhibitory activities against topoisomerase I and II by polyhydroxybenzoyl amide derivatives and their structure-activity relationship.

Kumamoto University

Novel oxazolidinone-quinolone hybrid antimicrobials.

Vicuron Pharmaceuticals

Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II ? over ?.

Istituto Italiano Di Tecnologia

New series of isoxazole derivatives targeting EGFR-TK: Synthesis, molecular modeling and antitumor evaluation.

Mansoura University

Synthesis and biological activities of NB-506 analogues modified at the glucose group.

Banyu Tsukuba Research Institute

Design, Synthesis and Anticancer Evaluation of New Substituted Thiophene-Quinoline Derivatives.

Kyushu Institute of Technology1-1 Sensuicho

Synthesis and biological activities of topoisomerase I inhibitors, 6-N-amino analogues of NB-506.

Banyu Tsukuba Research Institute

Discovery of Novel Topoisomerase II Inhibitors by Medicinal Chemistry Approaches.

Shandong University

Discovery of 4,6-

Hubei University of Technology

Garcinol and Related Polyisoprenylated Benzophenones as Topoisomerase II Inhibitors: Biochemical and Molecular Modeling Studies.

European Biomedical Research Institute of Salerno (Ebris)

Design, synthesis and biological evaluation of 1,4-dihydroxyanthraquinone derivatives as anticancer agents.

Guangxi University

Synthetic lanostane-type triterpenoids as inhibitors of DNA topoisomerase II.

Osaka University of Pharmaceutical Sciences

Synthesis and antibacterial activity of novel 6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-4-oxoquinoline-3-carboxylic acids bearing cyclopropane-fused 2-amino-8-azabicyclo[4.3.0]nonan-8-yl substituents at the C-7 position.

Daiichi Pharmaceutical

Discovery of (3S)-amino-(4R)-ethylpiperidinyl quinolones as potent antibacterial agents with a broad spectrum of activity and activity against resistant pathogens.

Procter & Gamble Pharmaceuticals

Synthesis and structure-activity relationships of novel 7-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids as antitumor agents. Part 1.

Dainippon Pharmaceutical

seco-Cyclothialidines: new concise synthesis, inhibitory activity toward bacterial and human DNA topoisomerases, and antibacterial properties.

Bayer

Synthesis and antitumor activity of new glycosides of epipodophyllotoxin, analogues of etoposide, and NK 611.

Umr 176 Cnrs/Institut Curie

Design of new topoisomerase II inhibitors based upon a quinobenzoxazine self-assembly model.

The University of Texas At Austin

Synthesis and antitumor activity of 4-aminomethylthioxanthenone and 5-aminomethylbenzothiopyranoindazole derivatives.

Sanofi Winthrop

Antitumor agents. 185. Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors.

University of North Carolina At Chapel Hill

DNA gyrase inhibitory and antimicrobial activities of some diphenic acid monohydroxamides.

R.W. Johnson Pharmaceutical Research Institute

Dicationic diarylfurans as anti-Pneumocystis carinii agents.

Georgia State University

9-substituted acridine derivatives with long half-life and potent antitumor activity: synthesis and structure-activity relationships.

Sloan-Kettering Institute For Cancer Research

6-Arylamino-7-chloro-quinazoline-5,8-diones as novel cytotoxic and DNA topoisomerase inhibitory agents.

Ewha Womans University

Design and synthesis of thienopyrimidine urea derivatives with potential cytotoxic and pro-apoptotic activity against breast cancer cell line MCF-7.

Cairo University

Novel ciprofloxacin hybrids using biology oriented drug synthesis (BIODS) approach: Anticancer activity, effects on cell cycle profile, caspase-3 mediated apoptosis, topoisomerase II inhibition, and antibacterial activity.

Cairo University

Design, synthesis and screening of 1, 2, 4-triazinone derivatives as potential antitumor agents with apoptosis inducing activity on MCF-7 breast cancer cell line.

Port Said University