BDBM50014846 (S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide::(S)-colchicine::7alphaH-colchicine::CHEMBL107::COLCHICINE::N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide::colchicina::colchicinum
SMILES COc1cc2CC[C@H](NC(C)=O)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC
InChI Key InChIKey=IAKHMKGGTNLKSZ-INIZCTEOSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 83 hits for monomerid = 50014846
Affinity DataKi: 1.60nMAssay Description:Binding affinity to pig brain tubulinMore data for this Ligand-Target Pair
TargetSolute carrier family 22 member 3(Homo sapiens (Human))
University Of Heidelberg
Curated by ChEMBL
University Of Heidelberg
Curated by ChEMBL
Affinity DataKi: 120nMAssay Description:TP_TRANSPORTER: inhibition of MPP+ uptake in OCT3-expressing HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 780nMAssay Description:Binding constant at colchicine site of bovine brain tubulinMore data for this Ligand-Target Pair
Affinity DataKi: 2.50E+3nMAssay Description:Compound was evaluated for its ability to inhibit the binding of [3H]-colchicine to tubulin in competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 5.75E+3nMAssay Description:Binding affinity against tubulin usingf [3H]-colchicine as radioligandMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 0 group B member 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
TargetSteroidogenic factor 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
Affinity DataIC50: 800nMAssay Description:Inhibition of tubulin polymerizationMore data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Inhibition of bovine tubulin polymerizationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.12E+7nMAssay Description:Inhibition of tubulin polymerizationMore data for this Ligand-Target Pair
Affinity DataEC50: 750nMAssay Description:Inhibition of Bos taurus (bovine) brain tubulin polymerizationMore data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Inhibition of tubulin polymerization(ITP)More data for this Ligand-Target Pair
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization after 20 mins by turbidimetric methodMore data for this Ligand-Target Pair
TargetSimilar to alpha-tubulin isoform 1/Tubulin beta-2B chain(Bos taurus)
Csir-Indian Institute Of Chemical Technology
Curated by ChEMBL
Csir-Indian Institute Of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization measured for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization incubated for 20 mins by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant human HDAC1 expressed in baculovirus infected insect High5 cells using Ac-Lys-Tyr-Lys (epsilon-acetyl)-AMC as substrate aft...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant human HDAC2 expressed in baculovirus infected insect High5 cells using Ac-Lys-Tyr-Lys (epsilon-acetyl)-AMC as substrate aft...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant human HDAC3 expressed in baculovirus infected insect High5 cells using Ac-Lys-Tyr-Lys (epsilon-acetyl)-AMC as substrate aft...More data for this Ligand-Target Pair
TargetSimilar to alpha-tubulin isoform 1/Tubulin beta-2B chain(Bos taurus)
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 2.62E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization extent after 20 mins by turbidimetricallyMore data for this Ligand-Target Pair
TargetSimilar to alpha-tubulin isoform 1/Tubulin beta-2B chain(Bos taurus)
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.79E+3nMAssay Description:Inhibition of porcine tubulin polymerization by UV-Vis microplate reader analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:The compound was evaluated in vitro for the mammalian brain tubulin polymerization using standard assay.More data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMAssay Description:Compound was evaluated for in vitro inhibitory activity against polymerization of tubulin into microtubules isolated from bovine brain at 1 mg/mL tub...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Tested for 50 % inhibition of tubulin polymerization by turbidimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibitory effect on the polymerization of purified bovine brain tubulin.More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human cytochrome P450 3A4More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of P-glycoprotein using calcein-AM assay transfected in porcine PBCECMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:In vitro inhibition of purified bovine brain tubulin polymerisation in the absence of microtubule-associated proteins.More data for this Ligand-Target Pair
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of tubulin polymerization activity using homogenous bovine brain tubulin at 45 degree CMore data for this Ligand-Target Pair
Affinity DataIC50: 1.12E+4nMAssay Description:Inhibition of tubulin polymerization activity using homogenous bovine brain tubulin at 30 degree CMore data for this Ligand-Target Pair
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of tubulin polymerization activity using homogenous bovine brain tubulin at 37 degree CMore data for this Ligand-Target Pair
Affinity DataIC50: 2.93E+4nMAssay Description:Concentration of compound required to inhibit tubulin polymerization (Microtubule assembly) was determined by the turbidity formation after 20 min of...More data for this Ligand-Target Pair
Affinity DataIC50: 4.17E+3nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.12E+4nMAssay Description:Compound was evaluated for inhibition of tubulin polymerization using purified bovine brain tubulin, activity expressed as IC50More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro tubulin polymerization-inhibitory activity.More data for this Ligand-Target Pair
Affinity DataIC50: >1.35E+5nMAssay Description:Compound was tested for its ability to inhibit C-C chemokine receptor type 3 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 2.99E+5nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of tubulin polymerization with preincubation for 15 minutes at 37 degree Centigrade prior to addition of the GTP required for polymerizati...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.93E+3nMAssay Description:Inhibition of tubulin beta polymerization in human MCF7 cells after 18 to 24 hrs by ELISA based spectrophotometric analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human PIM1 measured after 5 mins by ELISA relative to controlMore data for this Ligand-Target Pair
Affinity DataIC50: 1.26E+3nMAssay Description:In vitro inhibitory concentration required to displace [3H]colchicine from its binding site on tubulinMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:In vitro inhibition of maximum porcine tubulin assembly rate after 20 min at 37 degrees CMore data for this Ligand-Target Pair