BDBM50237342 CHEMBL4076129

SMILES CN[C@@H]1Cc2cccc3n(CCCCCCCCCCOCCCCc4ccccc4)c(=O)n(C1)c23

InChI Key InChIKey=HEHAZZLOEUQBDS-UHFFFAOYSA-N

Data  2 KI  4 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50237342   

TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50237342(CHEMBL4076129)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]-(R)-(+)-7-OH-DPAT from human dopamine D2 receptor expressed in HEK293 cell membranes after 90 mins by micro beta scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2019
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50237342(CHEMBL4076129)
Affinity DataKi:  113nMAssay Description:Displacement of [3H]-(R)-(+)-7-OH-DPAT from human dopamine D3 receptor expressed in HEK293 cell membranes after 90 mins by micro beta scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2019
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50237342(CHEMBL4076129)
Affinity DataEC50:  710nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in HEK293 cells assessed as cAMP inhibition by BRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2019
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50237342(CHEMBL4076129)
Affinity DataIC50: 802nMAssay Description:Antagonist activity at human dopamine D2 receptor expressed in HEK293 cells coexpressing renilla luciferase-fused GalphaoA/GFP10-fused Ggamma2 assess...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2019
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50237342(CHEMBL4076129)
Affinity DataEC50:  2.53E+3nMAssay Description:Agonist activity at renilla luciferase-tagged human dopamine D2 receptor expressed in HEK293 cells coexpressing mVenus-fused beta-arrestin 2 assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2019
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50237342(CHEMBL4076129)
Affinity DataIC50: 4.49E+3nMAssay Description:Antagonist activity at human dopamine D2 receptor expressed in forskolin stimulated-HEK293 cells coexpressing renilla luciferase-fused Galphai1/GFP10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2019
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50237342(CHEMBL4076129)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in HEK293 cells coexpressing renilla luciferase-fused Galphai1/GFP10-fused Ggamma2 by BRET a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2019
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50237342(CHEMBL4076129)
Affinity DataIC50: 5.00E+3nMAssay Description:Antagonist activity at human dopamine D2 receptor expressed in HEK293 cells assessed as reduction in quinpirole-mediated cAMP inhibition preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2019
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50237342(CHEMBL4076129)
Affinity DataIC50: 5.00E+3nMAssay Description:Antagonist activity at renilla luciferase-tagged human dopamine D2 receptor expressed in HEK293 cells coexpressing mVenus-fused beta-arrestin 2 asses...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2019
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50237342(CHEMBL4076129)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in HEK293 cells coexpressing renilla luciferase-fused GalphaoA/GFP10-fused Ggamma2 by BRET a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2019
Entry Details Article
PubMed