BDBM50543774 CHEMBL4640855

SMILES Nc1nc([O-])c2[n+](Cc3ccccc3)cn([C@@H]3O[C@H](COP(O)(S)=O)[C@@H](O)[C@H]3O)c2n1

InChI Key InChIKey=RHVBFUUBRLMWIC-XNIJJKJLSA-N

Data  1 KI  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50543774   

Targetm7GpppX diphosphatase(Homo sapiens (Human))
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543774(CHEMBL4640855)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human DcpS using pyrene labeled 7-methylguanosine triphosphate as substrate preincubated for 15 mins followed by enzyme addition by flu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 4E(Mus musculus)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543774(CHEMBL4640855)
Affinity DataKd:  344nMAssay Description:Binding affinity to murine eIF4E assessed as intrinsic fluorescence quenching of tryptophan residues by fluorescence spectrophotometric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 4E(Oryctolagus cuniculus)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543774(CHEMBL4640855)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of eIF4E in rabbit reticulocyte lysate system assessed as reduction in ARCA mRNA cap-dependent translation measured after 60 mins by lucif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed