BDBM808405 1-methyl-5-[7- oxo-3-(2-{[(3S)- piperidin-3- yl]amino}-5- (trifluoromethyl)py- rimidin-4-yl)- 1H,6H,7H- pyrrolo[2,3- c]pyridin-6-yl]- 1,2- dihydropyridin-2- one::US20260137698, Compound CDK7-1052
SMILES Cn1cc(-n2ccc3c(-c4nc(N[C@H]5CCCNC5)ncc4C(F)(F)F)c[nH]c3c2=O)ccc1=O
InChI Key InChIKey=IMBKPIBUVPWLBD-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 808405
Affinity DataIC50: 5nMAssay Description:Cryopreserved human PBMCs were obtained from AllCells (cat# PB003F). After thawing/dilution protocols using RPMI medium supplemented with 5% FBS (hea...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 10nMAssay Description:Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 200nMAssay Description:Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 200nMAssay Description:Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 479nMAssay Description:Cryopreserved human PBMCs were obtained from AllCells (cat# PB003F). After thawing/dilution protocols using RPMI medium supplemented with 5% FBS (hea...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 1.24E+4nMAssay Description:The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...More data for this Ligand-Target Pair
Ligand Info