BDBM50232973 CHEMBL254129::CYCLOPAMINE
SMILES C[C@@H]1[C@@H]2NC[C@@H](C)C[C@H]2O[C@]11CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC2=C1C
InChI Key InChIKey=QASFUMOKHFSJGL-LAFRSMQTSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50232973
Affinity DataKi: 12.7nMAssay Description:Displacement of [3H]cyclopamine from wild type Smo expressed in U2OS cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of SHH pathway in mouse Shh Light2 cells after 40 hrs by Gli-dependent luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of N-terminal SHH activated pathway in mouse C3H10T1/2 cells assessed as SAG-induced cell differentiation by alkaline phosphatase assayMore data for this Ligand-Target Pair
Affinity DataKd: 12.4nMAssay Description:Binding affinity to wild type Smo expressed in U2OS cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 484nMAssay Description:Antagonist activity at Smo in mouse Shh-Light 2 cells assessed as inhibition of Shh-induced Gli1-reporter activity after 2 days by dual-luciferase re...More data for this Ligand-Target Pair
Affinity DataIC50: 64nMAssay Description:Displacement of BODIPY-labelled cyclopamine from human Smo receptor expressed in HEK293 cells after 2 hrs by fluorescence microscopyMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 280nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of Smo in mouse Ptch-deficient MEF cells assessed as inhibition of Shh-induced Gli1 transcriptional activityMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of Smo in mouse Ptch-deficient MEF cells assessed as inhibition of Shh-induced Gli-responsive betagalactosidase activity after 30 hrs by B...More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of human Shh-induced mouse C3H10T1/2 cell differentiation after 48 hrs by alkaline phosphatase reporter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.31E+3nMAssay Description:Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAGMore data for this Ligand-Target Pair
Affinity DataEC50: 500nMAssay Description:Inhibition of SHH in mouse Shh Light2 cells by GLI-responsive firefly luciferase reporter gene assayMore data for this Ligand-Target Pair