BDBM50232973 CHEMBL254129::CYCLOPAMINE
SMILES C[C@@H]1[C@@H]2NC[C@@H](C)C[C@H]2O[C@]11CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC2=C1C
InChI Key InChIKey=QASFUMOKHFSJGL-LAFRSMQTSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50232973
Affinity DataKi: 12.7nMAssay Description:Displacement of [3H]cyclopamine from wild type Smo expressed in U2OS cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKd: 12.4nMAssay Description:Binding affinity to wild type Smo expressed in U2OS cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 484nMAssay Description:Antagonist activity at Smo in mouse Shh-Light 2 cells assessed as inhibition of Shh-induced Gli1-reporter activity after 2 days by dual-luciferase re...More data for this Ligand-Target Pair