BDBM103835 SPI-10::US11041859, Code SPI-10::US9791447, Compound SPI-10

SMILES Nc1ccc(\N=N\c2cccc(c2)S([O-])(=O)=O)c2ccccc12

InChI Key InChIKey=COAVSGQDMBDKLG-VHEBQXMUSA-M

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 103835   

TargetSentrin-specific protease 1(Homo sapiens (Human))
Beckman Research Institute of The City of Hope

LigandPNGBDBM103835(SPI-10 | US11041859, Code SPI-10 | US9791447, Comp...)
Affinity DataIC50: >6.00E+7nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 2(Homo sapiens (Human))
Beckman Research Institute of The City of Hope

LigandPNGBDBM103835(SPI-10 | US11041859, Code SPI-10 | US9791447, Comp...)
Affinity DataIC50:  3.42E+4nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Beckman Research Institute of The City of Hope

LigandPNGBDBM103835(SPI-10 | US11041859, Code SPI-10 | US9791447, Comp...)
Affinity DataIC50:  1.11E+4nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 2(Homo sapiens (Human))
Beckman Research Institute of The City of Hope

LigandPNGBDBM103835(SPI-10 | US11041859, Code SPI-10 | US9791447, Comp...)
Affinity DataIC50:  3.64E+4nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Beckman Research Institute of The City of Hope

LigandPNGBDBM103835(SPI-10 | US11041859, Code SPI-10 | US9791447, Comp...)
Affinity DataIC50:  2.40E+3nMAssay Description:The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease 2(Homo sapiens (Human))
Beckman Research Institute of The City of Hope

LigandPNGBDBM103835(SPI-10 | US11041859, Code SPI-10 | US9791447, Comp...)
Affinity DataIC50:  2.50E+3nMAssay Description:The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease 7(Homo sapiens (Human))
City of Hope

US Patent
LigandPNGBDBM103835(SPI-10 | US11041859, Code SPI-10 | US9791447, Comp...)
Affinity DataIC50:  2.00E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease/Small ubiquitin-related modifier 1(Homo sapiens (Human))
City of Hope

US Patent
LigandPNGBDBM103835(SPI-10 | US11041859, Code SPI-10 | US9791447, Comp...)
Affinity DataIC50: >6.00E+4nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease 2/Small ubiquitin-related modifier 1(Homo sapiens (Human))
City of Hope

US Patent
LigandPNGBDBM103835(SPI-10 | US11041859, Code SPI-10 | US9791447, Comp...)
Affinity DataIC50:  3.42E+4nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSmall ubiquitin-related modifier 1/2(Homo sapiens (Human))
City of Hope

US Patent
LigandPNGBDBM103835(SPI-10 | US11041859, Code SPI-10 | US9791447, Comp...)
Affinity DataIC50:  1.11E+4nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease/Small ubiquitin-related modifier 2(Homo sapiens (Human))
City of Hope

US Patent
LigandPNGBDBM103835(SPI-10 | US11041859, Code SPI-10 | US9791447, Comp...)
Affinity DataIC50:  3.64E+4nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease 1(Homo sapiens (Human))
Beckman Research Institute of The City of Hope

LigandPNGBDBM103835(SPI-10 | US11041859, Code SPI-10 | US9791447, Comp...)
Affinity DataIC50:  2.40E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease 2(Homo sapiens (Human))
Beckman Research Institute of The City of Hope

LigandPNGBDBM103835(SPI-10 | US11041859, Code SPI-10 | US9791447, Comp...)
Affinity DataIC50:  2.50E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease 7(Homo sapiens (Human))
City of Hope

US Patent
LigandPNGBDBM103835(SPI-10 | US11041859, Code SPI-10 | US9791447, Comp...)
Affinity DataIC50:  2.00E+3nMAssay Description:The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...More data for this Ligand-Target Pair
In DepthDetails US Patent