BDBM104010 DDR1-IN-2

SMILES CCN1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2ccc(C)c(NCc3cnc4[nH]ccc4c3OC)c2)CC1

InChI Key InChIKey=PBHDCPWPSOSGGD-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 104010   

TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Massachusetts General Hospital and Harvard Medical School

LigandPNGBDBM104010(DDR1-IN-2)
Affinity DataEC50:  9nMAssay Description:The enzyme kinase assay was carried out using the Lanthascreen technology.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Massachusetts General Hospital and Harvard Medical School

LigandPNGBDBM104010(DDR1-IN-2)
Affinity DataIC50:  47.6nMAssay Description:Tet inducible human DDR1 over-expressing U2OS was pre-treated by media containing each of the compound for 1 hour and treated by changing the media t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Massachusetts General Hospital and Harvard Medical School

LigandPNGBDBM104010(DDR1-IN-2)
Affinity DataIC50:  47nMAssay Description:Inhibition of human DDR1 kinase domain (601 to 913 residues) expressed in Sf9 cells by enzymatic kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Massachusetts General Hospital and Harvard Medical School

LigandPNGBDBM104010(DDR1-IN-2)
Affinity DataIC50:  9nMAssay Description:Inhibition of human DDR1 in doxycycline-stimulated human U2OS cells assessed as inhibition of collagen-1-induced autophosphorylation incubated for 1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Massachusetts General Hospital and Harvard Medical School

LigandPNGBDBM104010(DDR1-IN-2)
Affinity DataIC50:  145nMAssay Description:Tet inducible human DDR1 over-expressing U2OS was pre-treated by media containing each of the compound for 1 hour and treated by changing the media t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed