BindingDB BDBM112777 NORTRIPTYLINE::US8629135, SW-02

BDBM112777 NORTRIPTYLINE::US8629135, SW-02

SMILES [#6]-[#7]-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12

InChI Key InChIKey=PHVGLTMQBUFIQQ-UHFFFAOYSA-N

Data 44 KI 26 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 112777

Cytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL

BDBM112777(NORTRIPTYLINE | US8629135, SW-02)

IC50: 2.60E+3nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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KEGG PC cid PC sid PDB Similars

Details Article PubMed

Filter my 70 hits

Targets 37▿
- Sodium-dependent serotonin transporter 10
- Sodium-dependent noradrenaline transporter 6
- Histamine H1 receptor 4
- Sodium-dependent dopamine transporter 4
- 5-hydroxytryptamine receptor 6 3
- Proto-oncogene tyrosine-protein kinase receptor Ret 2
- Alpha-1A adrenergic receptor 2
- 5-hydroxytryptamine receptor 2C 2
- Norepinephrine transporter 2
- Sodium- and chloride-dependent betaine transporter 2
- Muscarinic acetylcholine receptor M2 2
- Sodium- and chloride-dependent GABA transporter 1 2
- Cytochrome P450 2D6 2
- Sodium- and chloride-dependent GABA transporter 3 2
- Bile salt export pump 2
- Sodium- and chloride-dependent GABA transporter 2 2
- Sigma non-opioid intracellular receptor 1 1
- Voltage-dependent N-type calcium channel subunit alpha-1B 1
- Muscarinic acetylcholine receptor M5 1
- Muscarinic acetylcholine receptor M4 1
- Muscarinic acetylcholine receptor M3 1
- Muscarinic acetylcholine receptor M1 1
- Beta-2 adrenergic receptor 1
- ATP-binding cassette sub-family C member 3 1
- Cytochrome P450 2D3 1
- ATP-binding cassette sub-family C member 4 1
- Cytochrome P450 2D4 1
- ATP-binding cassette sub-family C member 2 1
- Cytochrome P450 2D1 1
- D(2) dopamine receptor 1
- 5-hydroxytryptamine receptor 1A 1
- 5-hydroxytryptamine receptor 2A 1
- Cytochrome P450 2D26 1
- Sodium channel protein type 1/2/3 subunit alpha 1
- Cytochrome P450 2C8 1
- Alpha-2A adrenergic receptor 1
- Histamine H2 receptor 1
- ...
Publications 26▿
- Bioorg Med Chem 23: 2480-8 (2015) 8
- Psychopharmacology (Berl) 114: 559-65 (1994) 7
- Biol Psychiatry 55: 320-2 (2004) 6
- J Pharmacol Exp Ther 283: 1305-22 (1997) 6
- J Med Chem 46: 74-86 (2002) 5
- Biochem Pharmacol 45: 2352-4 (1993) 5
- Toxicol Sci 136: 216-41 (2013) 4
- J Pharmacol Exp Ther 226: 686-700 (1983) 3
- Psychopharmacology (Berl) 126: 234-40 (1996) 3
- Eur J Pharmacol 340: 249-58 (1997) 3
- J Med Chem 42: 3154-62 (1999) 3
- US Patent US8629135 (2014) 2
- Neuropharmacology 32: 737-43 (1993) 2
- RSC Med Chem 13: 183-195 (2022) 1
- J Med Chem 43: 1011-8 (2000) 1
- Mol Pharmacol 12: 568-80 (1976) 1
- J Med Chem 47: 5340-6 (2004) 1
- Curr Drug Metab 6: 413-54 (2005) 1
- Neuropharmacology 33: 275-317 (1994) 1
- Toxicol Sci 118: 485-500 (2010) 1
- J Med Chem 28: 381-8 (1985) 1
- Proc Natl Acad Sci U S A 75: 6290-4 (1978) 1
- J Pharm Pharmacol 38: 374-9 (1986) 1
- Brain Res 304: 1-7 (1984) 1
- Mol Pharmacol 43: 320-7 (1993) 1
- J Med Chem 55: 5704-19 (2012) 1
Institutions 19▿
- Emory University 12
- Mayo Clinic 10
- University Of Copenhagen 8
- Mayo Foundation 6
- Amgen 5
- Vrije Universiteit 5
- TBA 4
- Universidad De Valencia 3
- University Of Turku 3
- Pfizer 3
- Queen'S University At Kingston 2
- Boots Pharmaceuticals 2
- University Of Alberta 1
- University Of North Carolina At Chapel Hill 1
- The University Of Queensland 1
- F. Hoffmann-La Roche 1
- Virginia Commonwealth University 1
- University Of Leicester 1
- National Institute Of Neurological Disorders And Stroke 1
Affinity: 0.040 to 3.9E+5 nM▿
- Ki 44
- IC50 26
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1