BDBM112777 NORTRIPTYLINE::US8629135, SW-02

SMILES [#6]-[#7]-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12

InChI Key InChIKey=PHVGLTMQBUFIQQ-UHFFFAOYSA-N

Data  44 KI  26 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 112777   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Queen'S University At Kingston

US Patent
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataIC50:  5.00E+3nMpH: 7.4 T: 2°CAssay Description:Approximately 5-20 μg of purified GST-RET proteins were incubated with 1 mM ATP in 20 μL kinase buffer (10 mM Tris-HCl, 5 mM MgCl2, pH 7.4)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Queen'S University At Kingston

US Patent
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataIC50:  1.50E+3nMpH: 7.4 T: 2°CAssay Description:Approximately 5-20 μg of purified GST-RET proteins were incubated with 1 mM ATP in 20 μL kinase buffer (10 mM Tris-HCl, 5 mM MgCl2, pH 7.4)...More data for this Ligand-Target Pair
In DepthDetails US Patent