BDBM14244 4,5-dibromo-3-(carboxymethoxy)thiophene-2-carboxylic acid::CHEMBL373413::Monocyclic thiophene analog 10

SMILES OC(=O)COc1c(Br)c(Br)sc1C(O)=O

InChI Key InChIKey=JBNUJOXGKKSAFH-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 14244   

TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14244(4,5-dibromo-3-(carboxymethoxy)thiophene-2-carboxyl...)
Affinity DataKi:  1.80E+4nM ΔG°:  -6.40kcal/molepH: 7.0 T: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM14244(4,5-dibromo-3-(carboxymethoxy)thiophene-2-carboxyl...)
Affinity DataKi:  1.80E+4nMAssay Description:Inhibition of PTP1B assessed as pNPP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM14244(4,5-dibromo-3-(carboxymethoxy)thiophene-2-carboxyl...)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition of PTP1B assessed as pNPP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed