BDBM14361 (R,S)-Rolipram::4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrolidin-2-one::4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one::Adeo::CHEMBL63::Rolipram

SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1

InChI Key InChIKey=HJORMJIFDVBMOB-UHFFFAOYSA-N

Data  29 KI  243 IC50  3 EC50

PDB links: 9 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 14361   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  2.46E+5nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  2.70E+6nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and calmodu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair