BDBM144614 US8969586, 1::US9598436, 1

SMILES Cc1ccncc1-c1cccc2c(noc12)-c1ccccc1

InChI Key InChIKey=OQORIDVPVHCIRH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 144614   

TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM144614(US8969586, 1 | US9598436, 1)
Affinity DataIC50:  1.10nMpH: 7.2 T: 2°CAssay Description:The assays were performed in U-bottom 384-well optiplates. The final assay volume was 15 μl prepared from 7.5 μl additions of microsomes (p...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 1A2(Homo sapiens (Human))TBA
LigandPNGBDBM144614(US8969586, 1 | US9598436, 1)
Affinity DataIC50:  28nMAssay Description:Antagonist activity at RXRalpha expressed in COS1 cells assessed as inhibition of NEt-TMN-induced luciferase activity after 18 hrs by reporter gene a...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM144614(US8969586, 1 | US9598436, 1)
Affinity DataIC50:  1nMAssay Description:Binding affinity against Melatonin receptor using ovine pars tuberalis membranes of the pituitary.More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM144614(US8969586, 1 | US9598436, 1)
Affinity DataIC50:  1.10nMAssay Description:The assays were performed in U-bottom 384-well optiplates. The final assay volume was 15 μl prepared from 7.5 μl additions of microsomes (p...More data for this Ligand-Target Pair
In DepthDetails US Patent